Is frozen fecal microbiota transplantation as effective as fresh fecal microbiota transplantation in patients with recurrent or refractory clostridium difficile infection: a meta-analysis?

Is frozen fecal microbiota transplantation as effective as fresh fecal microbiota transplantation in patients with recurrent or refractory clostridium difficile infection: a meta-analysis?

Abstract Fecal microbiota transplantation (FMT) is a remarkably efficacious therapy for recurrent or refractory Clostridium difficile infection (CDI), but not standardized. This work is to determine whether frozen FMT is as effective as fresh FMT. Meta-analysis showed that frozen FMT was as effectiv...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diagnostic microbiology and infectious disease 2017-08, Vol.88 (4), p.322-329
Hauptverfasser: Tang, Guihua, Yin, Wen, Liu, Wenen
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Clostridium difficile
Clostridium difficile - pathogenicity
Clostridium Infections - microbiology
Clostridium Infections - therapy
Fecal Microbiota Transplantation - methods
Feces - microbiology
Female
Freezing
Fresh fecal microbiota transplantation
Frozen fecal microbiota transplantation
Humans
Infectious Disease
Internal Medicine
Male
Microbiota - physiology
Middle Aged
Recurrence
Treatment Outcome
Young Adult
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract Fecal microbiota transplantation (FMT) is a remarkably efficacious therapy for recurrent or refractory Clostridium difficile infection (CDI), but not standardized. This work is to determine whether frozen FMT is as effective as fresh FMT. Meta-analysis showed that frozen FMT was as effective as fresh FMT, both pooled first effective rate (65.0% (95% CI 57.0%, 73.0%) vs. 65.0% (95% CI 57.0%, 73.0%), p = 0.962) and pooled second effective rate (95.0% (95% CI 91.0%, 99.0%) vs. 95.0% (95% CI 92.0%, 99.0%), p = 0.880). In conclusion, among patients with recurrent or refractory CDI, frozen FMT is as effective as fresh FMT. Considering potential advantages of performing frozen FMT, it is a reasonable option to select frozen FMT.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2017.05.007