Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro

Idiopathic pulmonary arterial hypertension (IPAH) is a fatal disease of the pulmonary artery resulting from a currently unidentified etiology. IPAH is pathologically characterized as sustained vasoconstriction and vascular remodeling of the pulmonary artery. Vascular remodeling is mediated by enhanc...

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Veröffentlicht in:	European journal of pharmacology 2017-09, Vol.810, p.44-50
Hauptverfasser:	Yamamura, Aya, Fujitomi, Eri, Ohara, Naoki, Tsukamoto, Kikuo, Sato, Motohiko, Yamamura, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line Cell Proliferation - drug effects Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics Down-Regulation - drug effects Familial Primary Pulmonary Hypertension - drug therapy Familial Primary Pulmonary Hypertension - enzymology Familial Primary Pulmonary Hypertension - genetics Familial Primary Pulmonary Hypertension - pathology Humans Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - pathology Phosphodiesterase 5 Inhibitors - pharmacology Phosphodiesterase 5 Inhibitors - therapeutic use Phosphodiesterase type 5 Pulmonary artery Pulmonary Artery - pathology Pulmonary hypertension Smooth muscle Tadalafil Tadalafil - pharmacology Tadalafil - therapeutic use Vascular remodeling
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