Ceritinib versus chemotherapy in patients with ALK -rearranged non-small-cell lung cancer previously given chemotherapy and crizotinib (ASCEND-5): a randomised, controlled, open-label, phase 3 trial

Summary Background Ceritinib is a next-generation anaplastic lymphoma kinase (ALK) inhibitor, which has shown robust anti-tumour efficacy, along with intracranial activity, in patients with ALK -rearranged non-small-cell lung cancer. In phase 1 and 2 studies, ceritinib has been shown to be highly ac...

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Veröffentlicht in:	The lancet oncology 2017-07, Vol.18 (7), p.874-886
Hauptverfasser:	Shaw, Alice T, Dr, Kim, Tae Min, MD, Crinò, Lucio, Prof, Gridelli, Cesare, MD, Kiura, Katsuyuki, MD, Liu, Geoffrey, MD, Novello, Silvia, Prof, Bearz, Alessandra, MD, Gautschi, Oliver, MD, Mok, Tony, Prof, Nishio, Makoto, MD, Scagliotti, Giorgio, Prof, Spigel, David R, MD, Deudon, Stéphanie, PharmD, Zheng, Cheng, PhD, Pantano, Serafino, PhD, Urban, Patrick, MD, Massacesi, Cristian, MD, Viraswami-Appanna, Kalyanee, PhD, Felip, Enriqueta, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alanine Alanine transaminase Alanine Transaminase - blood Anaplastic Lymphoma Kinase Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aspartate aminotransferase Aspartate Aminotransferases - blood Brain cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - secondary Cerebrovascular system Chemotherapy Crizotinib Disease Progression Disease-Free Survival Docetaxel Enzyme inhibitors FDA approval Female gamma-Glutamyltransferase - blood Gene amplification Gene Rearrangement Hematology, Oncology and Palliative Medicine Humans Inhibitor drugs Intravenous administration Laboratories Life span Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Lymphoma Male Metastases Metastasis Middle Aged Motivation Mutation Neoplasm Staging Patients Pemetrexed - therapeutic use Platinum Platinum Compounds - administration & dosage Protein-tyrosine kinase Pyrazoles - therapeutic use Pyridines - therapeutic use Pyrimidines - adverse effects Pyrimidines - therapeutic use Receptor Protein-Tyrosine Kinases - genetics Respiratory failure Response Evaluation Criteria in Solid Tumors Retreatment Solid tumors Stroke Sulfones - adverse effects Sulfones - therapeutic use Survival Targeted cancer therapy Taxoids - therapeutic use
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