Effect of liraglutide on dietary lipid‐induced insulin resistance in humans

Aims To test whether liraglutide suppresses postprandial elevations in lipids and thus protects against high saturated fatty acid (SFA) diet‐induced insulin resistance. Methods In a randomized placebo‐controlled crossover study, 32 participants with normal or mildly impaired glucose tolerance receiv...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2018-01, Vol.20 (1), p.69-76
Hauptverfasser:	Koska, Juraj, Lopez, Lizette, D'Souza, Karen, Osredkar, Tracy, Deer, James, Kurtz, Julie, Salbe, Arline D., Harman, Sherman M., Reaven, Peter D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adult Aged AMP AMP-activated protein kinase Antidiabetics Arterioles Body Mass Index Cohort Studies Cross-Over Studies Diet Diet, High-Fat - adverse effects Fatty acids Female Glucagon-Like Peptide-1 Receptor - agonists Glucagon-Like Peptide-1 Receptor - metabolism Glucose Glucose metabolism Glucose tolerance Humans Hyperlipidemias - blood Hyperlipidemias - etiology Hyperlipidemias - metabolism Hyperlipidemias - prevention & control Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Incretins - pharmacology Incretins - therapeutic use Insulin Insulin Resistance Kinases Lipids liraglutide Liraglutide - pharmacology Liraglutide - therapeutic use Male Microvasculature Microvessels - drug effects Middle Aged Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Musculoskeletal system Overweight - physiopathology Phosphorylation Postprandial Period Prediabetic State - drug therapy Prediabetic State - etiology Prediabetic State - metabolism Prediabetic State - prevention & control randomised trial Regulatory proteins Skeletal muscle Subcutaneous Fat, Abdominal - blood supply Subcutaneous Fat, Abdominal - drug effects Thioredoxin Triglycerides Vasodilation Vasodilation - drug effects
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