Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation
Although the Apiaceae herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the Apiaceae family, were evaluated for their effects on adipogenesis. We found that suksdorfin s...
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| Veröffentlicht in: | Lipids 2017-07, Vol.52 (7), p.657-664 |
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| creator | Iwase, Mari Yamamoto, Takayuki Nishimura, Kanako Takahashi, Haruya Mohri, Shinsuke Li, Yongjia Jheng, Huei-Fen Nomura, Wataru Takahashi, Nobuyuki Kim, Chu-Sook Yu, Rina Taniguchi, Masahiko Baba, Kimiye Murakami, Shigeru Kawada, Teruo Goto, Tsuyoshi |
| description | Although the
Apiaceae
herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the
Apiaceae
family, were evaluated for their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production of adiponectin, an anti-diabetic adipokine. We also demonstrated that suksdorfin activates peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipogenesis. Furthermore, we showed metabolic disorders in obese diabetic KK-A
y
mice were attenuated by suksdorfin feeding. Suksdorfin intake induced adipocyte miniaturization and increased expression levels of PPARγ target genes related to adipocyte differentiation. These results indicated that suksdorfin induces adipogenesis in white adipose tissue (WAT) via the activation of PPARγ, leading to improvement of obesity-induced metabolic disorders. Therefore, suksdorfin-mediated amelioration of WAT dysfunctions might be responsible for the anti-diabetic effects of traditional herbal medicine therapy with
Apiaceae
. |
| doi_str_mv | 10.1007/s11745-017-4269-7 |
| format | Article |
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Apiaceae
herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the
Apiaceae
family, were evaluated for their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production of adiponectin, an anti-diabetic adipokine. We also demonstrated that suksdorfin activates peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipogenesis. Furthermore, we showed metabolic disorders in obese diabetic KK-A
y
mice were attenuated by suksdorfin feeding. Suksdorfin intake induced adipocyte miniaturization and increased expression levels of PPARγ target genes related to adipocyte differentiation. These results indicated that suksdorfin induces adipogenesis in white adipose tissue (WAT) via the activation of PPARγ, leading to improvement of obesity-induced metabolic disorders. Therefore, suksdorfin-mediated amelioration of WAT dysfunctions might be responsible for the anti-diabetic effects of traditional herbal medicine therapy with
Apiaceae
.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-017-4269-7</identifier><identifier>PMID: 28601955</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>3T3-L1 Cells ; Adipocyte differentiation ; Adipocytes - cytology ; Adipocytes - drug effects ; Adipocytes - metabolism ; Adiponectin - metabolism ; Animals ; Apiaceae - chemistry ; Biomedical and Life Sciences ; Cell Differentiation - drug effects ; Coumarin ; Coumarins - administration & dosage ; Coumarins - pharmacology ; Enzyme Activation - drug effects ; Gene Expression Regulation, Enzymologic - drug effects ; Glucose metabolism ; Glucose Metabolism Disorders - drug therapy ; Glucose Metabolism Disorders - enzymology ; Life Sciences ; Lipidology ; Medical Biochemistry ; Medicinal Chemistry ; Mice ; Mice, Obese ; Microbial Genetics and Genomics ; Neurochemistry ; Nutrition ; PPAR gamma - metabolism ; PPARγ ; Rapid Communication ; Signal Transduction - drug effects</subject><ispartof>Lipids, 2017-07, Vol.52 (7), p.657-664</ispartof><rights>AOCS 2017</rights><rights>2017 American Oil Chemists' Society (AOCS)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3927-6c89858a1f95ae7ce299c6175b530fdb8e2779fa7529f0d375971038360ee16f3</citedby><cites>FETCH-LOGICAL-c3927-6c89858a1f95ae7ce299c6175b530fdb8e2779fa7529f0d375971038360ee16f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11745-017-4269-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11745-017-4269-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,41464,42533,45550,45551,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28601955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwase, Mari</creatorcontrib><creatorcontrib>Yamamoto, Takayuki</creatorcontrib><creatorcontrib>Nishimura, Kanako</creatorcontrib><creatorcontrib>Takahashi, Haruya</creatorcontrib><creatorcontrib>Mohri, Shinsuke</creatorcontrib><creatorcontrib>Li, Yongjia</creatorcontrib><creatorcontrib>Jheng, Huei-Fen</creatorcontrib><creatorcontrib>Nomura, Wataru</creatorcontrib><creatorcontrib>Takahashi, Nobuyuki</creatorcontrib><creatorcontrib>Kim, Chu-Sook</creatorcontrib><creatorcontrib>Yu, Rina</creatorcontrib><creatorcontrib>Taniguchi, Masahiko</creatorcontrib><creatorcontrib>Baba, Kimiye</creatorcontrib><creatorcontrib>Murakami, Shigeru</creatorcontrib><creatorcontrib>Kawada, Teruo</creatorcontrib><creatorcontrib>Goto, Tsuyoshi</creatorcontrib><title>Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation</title><title>Lipids</title><addtitle>Lipids</addtitle><addtitle>Lipids</addtitle><description>Although the
Apiaceae
herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the
Apiaceae
family, were evaluated for their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production of adiponectin, an anti-diabetic adipokine. We also demonstrated that suksdorfin activates peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipogenesis. Furthermore, we showed metabolic disorders in obese diabetic KK-A
y
mice were attenuated by suksdorfin feeding. Suksdorfin intake induced adipocyte miniaturization and increased expression levels of PPARγ target genes related to adipocyte differentiation. These results indicated that suksdorfin induces adipogenesis in white adipose tissue (WAT) via the activation of PPARγ, leading to improvement of obesity-induced metabolic disorders. Therefore, suksdorfin-mediated amelioration of WAT dysfunctions might be responsible for the anti-diabetic effects of traditional herbal medicine therapy with
Apiaceae
.</description><subject>3T3-L1 Cells</subject><subject>Adipocyte differentiation</subject><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Adiponectin - metabolism</subject><subject>Animals</subject><subject>Apiaceae - chemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Coumarin</subject><subject>Coumarins - administration & dosage</subject><subject>Coumarins - pharmacology</subject><subject>Enzyme Activation - drug effects</subject><subject>Gene Expression Regulation, Enzymologic - drug effects</subject><subject>Glucose metabolism</subject><subject>Glucose Metabolism Disorders - drug therapy</subject><subject>Glucose Metabolism Disorders - enzymology</subject><subject>Life Sciences</subject><subject>Lipidology</subject><subject>Medical Biochemistry</subject><subject>Medicinal Chemistry</subject><subject>Mice</subject><subject>Mice, Obese</subject><subject>Microbial Genetics and Genomics</subject><subject>Neurochemistry</subject><subject>Nutrition</subject><subject>PPAR gamma - metabolism</subject><subject>PPARγ</subject><subject>Rapid Communication</subject><subject>Signal Transduction - drug effects</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM-O0zAQhy0EYsvCA3BBPnIJeJw6jo_V7rJUKqLiz9lynDHyksTFdor6XLwHz4RLFo5wGo3m9_s0-gh5DuwVMCZfJwC5FhUDWa15oyr5gKxAiLZSNZMPyYoxvi4XBhfkSUp3ZYW1Eo_JBW8bBkqIFckf56-pD9H5ie5jGEPGRDe9PwR7ykivvXMYccreZB8maqaebsdDDMdzrJtCHM3gsy9bAdwOsw0J6TvMpguDTyM9ekP3-82Hnz_oxmZ__I15Sh45MyR8dj8vyec3N5-u3la797fbq82usrXismpsq1rRGnBKGJQWuVK2ASk6UTPXdy1yKZUzUnDlWF9LoSSwuq0bhgiNqy_Jy4VbHv42Y8p69MniMJgJw5w0KNZKJWrgJQpL1MaQUkSnD9GPJp40MH2WrRfZusjWZ9lals6Le_zcjdj_bfyxWwJyCXz3A57-T9S77f6aNeKM5kszldL0BaO-C3Ociqx__PMLEXKcFQ</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Iwase, Mari</creator><creator>Yamamoto, Takayuki</creator><creator>Nishimura, Kanako</creator><creator>Takahashi, Haruya</creator><creator>Mohri, Shinsuke</creator><creator>Li, Yongjia</creator><creator>Jheng, Huei-Fen</creator><creator>Nomura, Wataru</creator><creator>Takahashi, Nobuyuki</creator><creator>Kim, Chu-Sook</creator><creator>Yu, Rina</creator><creator>Taniguchi, Masahiko</creator><creator>Baba, Kimiye</creator><creator>Murakami, Shigeru</creator><creator>Kawada, Teruo</creator><creator>Goto, Tsuyoshi</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation</title><author>Iwase, Mari ; Yamamoto, Takayuki ; Nishimura, Kanako ; Takahashi, Haruya ; Mohri, Shinsuke ; Li, Yongjia ; Jheng, Huei-Fen ; Nomura, Wataru ; Takahashi, Nobuyuki ; Kim, Chu-Sook ; Yu, Rina ; Taniguchi, Masahiko ; Baba, Kimiye ; Murakami, Shigeru ; Kawada, Teruo ; Goto, Tsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3927-6c89858a1f95ae7ce299c6175b530fdb8e2779fa7529f0d375971038360ee16f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>3T3-L1 Cells</topic><topic>Adipocyte differentiation</topic><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Adiponectin - metabolism</topic><topic>Animals</topic><topic>Apiaceae - chemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>Coumarin</topic><topic>Coumarins - administration & dosage</topic><topic>Coumarins - pharmacology</topic><topic>Enzyme Activation - drug effects</topic><topic>Gene Expression Regulation, Enzymologic - drug effects</topic><topic>Glucose metabolism</topic><topic>Glucose Metabolism Disorders - drug therapy</topic><topic>Glucose Metabolism Disorders - enzymology</topic><topic>Life Sciences</topic><topic>Lipidology</topic><topic>Medical Biochemistry</topic><topic>Medicinal Chemistry</topic><topic>Mice</topic><topic>Mice, Obese</topic><topic>Microbial Genetics and Genomics</topic><topic>Neurochemistry</topic><topic>Nutrition</topic><topic>PPAR gamma - metabolism</topic><topic>PPARγ</topic><topic>Rapid Communication</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwase, Mari</creatorcontrib><creatorcontrib>Yamamoto, Takayuki</creatorcontrib><creatorcontrib>Nishimura, Kanako</creatorcontrib><creatorcontrib>Takahashi, Haruya</creatorcontrib><creatorcontrib>Mohri, Shinsuke</creatorcontrib><creatorcontrib>Li, Yongjia</creatorcontrib><creatorcontrib>Jheng, Huei-Fen</creatorcontrib><creatorcontrib>Nomura, Wataru</creatorcontrib><creatorcontrib>Takahashi, Nobuyuki</creatorcontrib><creatorcontrib>Kim, Chu-Sook</creatorcontrib><creatorcontrib>Yu, Rina</creatorcontrib><creatorcontrib>Taniguchi, Masahiko</creatorcontrib><creatorcontrib>Baba, Kimiye</creatorcontrib><creatorcontrib>Murakami, Shigeru</creatorcontrib><creatorcontrib>Kawada, Teruo</creatorcontrib><creatorcontrib>Goto, Tsuyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwase, Mari</au><au>Yamamoto, Takayuki</au><au>Nishimura, Kanako</au><au>Takahashi, Haruya</au><au>Mohri, Shinsuke</au><au>Li, Yongjia</au><au>Jheng, Huei-Fen</au><au>Nomura, Wataru</au><au>Takahashi, Nobuyuki</au><au>Kim, Chu-Sook</au><au>Yu, Rina</au><au>Taniguchi, Masahiko</au><au>Baba, Kimiye</au><au>Murakami, Shigeru</au><au>Kawada, Teruo</au><au>Goto, Tsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation</atitle><jtitle>Lipids</jtitle><stitle>Lipids</stitle><addtitle>Lipids</addtitle><date>2017-07</date><risdate>2017</risdate><volume>52</volume><issue>7</issue><spage>657</spage><epage>664</epage><pages>657-664</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Although the
Apiaceae
herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the
Apiaceae
family, were evaluated for their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production of adiponectin, an anti-diabetic adipokine. We also demonstrated that suksdorfin activates peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipogenesis. Furthermore, we showed metabolic disorders in obese diabetic KK-A
y
mice were attenuated by suksdorfin feeding. Suksdorfin intake induced adipocyte miniaturization and increased expression levels of PPARγ target genes related to adipocyte differentiation. These results indicated that suksdorfin induces adipogenesis in white adipose tissue (WAT) via the activation of PPARγ, leading to improvement of obesity-induced metabolic disorders. Therefore, suksdorfin-mediated amelioration of WAT dysfunctions might be responsible for the anti-diabetic effects of traditional herbal medicine therapy with
Apiaceae
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28601955</pmid><doi>10.1007/s11745-017-4269-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Lipids, 2017-07, Vol.52 (7), p.657-664 |
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| subjects | 3T3-L1 Cells Adipocyte differentiation Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Adiponectin - metabolism Animals Apiaceae - chemistry Biomedical and Life Sciences Cell Differentiation - drug effects Coumarin Coumarins - administration & dosage Coumarins - pharmacology Enzyme Activation - drug effects Gene Expression Regulation, Enzymologic - drug effects Glucose metabolism Glucose Metabolism Disorders - drug therapy Glucose Metabolism Disorders - enzymology Life Sciences Lipidology Medical Biochemistry Medicinal Chemistry Mice Mice, Obese Microbial Genetics and Genomics Neurochemistry Nutrition PPAR gamma - metabolism PPARγ Rapid Communication Signal Transduction - drug effects |
| title | Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation |
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