Kidney Function, Proteinuria, and Cancer Incidence: The Korean Heart Study

Kidney Function, Proteinuria, and Cancer Incidence: The Korean Heart Study

Background Reported associations of estimated glomerular filtration rate (eGFR) with cancer risk are inconsistent, and data for the proteinuria-cancer relationship are sparse. We sought to quantify the associations of cancer incidence with eGFR and with proteinuria in a large population-based cohort...

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Veröffentlicht in:American journal of kidney diseases 2017-10, Vol.70 (4), p.512-521
Hauptverfasser: Mok, Yejin, PhD, Matsushita, Kunihiro, MD, PhD, Ballew, Shoshana H., PhD, Sang, Yingying, MS, Jung, Keum Ji, PhD, Lee, Sunmi, PhD, Jee, Sun Ha, PhD, Coresh, Josef, MD, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
cancer
cohort study
Estimated glomerular filtration rate (eGFR)
Female
Glomerular Filtration Rate
Humans
Incidence
kidney function
Male
Middle Aged
Neoplasms - complications
Neoplasms - epidemiology
Nephrology
Prospective Studies
proteinuria
Proteinuria - complications
renal damage
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
urine dipstick
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Zusammenfassung:Background Reported associations of estimated glomerular filtration rate (eGFR) with cancer risk are inconsistent, and data for the proteinuria-cancer relationship are sparse. We sought to quantify the associations of cancer incidence with eGFR and with proteinuria in a large population-based cohort. Study Design A prospective cohort study. Setting & Participants 242,583 adults (30-74 years old) without a diagnosis of cancer at baseline in the Korean Heart Study, based on health checkups in 1996 to 2004 with follow-up until 2012. Predictors Creatinine-based eGFR (≥90, 60-89, 45-59, and 
ISSN:0272-6386
1523-6838
DOI:10.1053/j.ajkd.2017.03.018