Not all boronic acids with a five-membered cycle induce tremor, neuronal damage and decreased dopamine

[Display omitted] •We analyzed the toxicity of boronic acids with five-membered cycles as substituent.•We found different profiles for each tested compound.•Three of six boron-containing compounds produced shaking behavior.•Not all tested compounds produced neuronal death in basal nuclei. Several st...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2017-09, Vol.62, p.92-99
Hauptverfasser:	Pérez-Rodríguez, Maribel, García-Mendoza, Esperanza, Farfán-García, Eunice D., Das, Bhaskar C., Ciprés-Flores, Fabiola J., Trujillo-Ferrara, José G., Tamay-Cach, Feliciano, Soriano-Ursúa, Marvin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Acids Acute toxicity Animal models Animals Basal ganglia Boric acid Boron Boron compounds Boronic Acids - chemistry Boronic Acids - toxicity Brain Brain - drug effects Brain - metabolism Brain - pathology Brain diseases Central nervous system Central nervous system diseases Cerebellum Chromatography, High Pressure Liquid Damage Disease Models, Animal Dopamine Dopamine - metabolism Exploratory Behavior - drug effects Ganglia High-performance liquid chromatography Immunohistochemistry Liquid chromatography Male Mice Mice, Inbred C57BL Motor activity Movement disorders MPTP Neostriatum Neurons - drug effects Neurons - pathology Neurotoxicity Parkinson's disease Phosphopyruvate Hydratase - metabolism Shaking Substantia nigra Thiophen Toxicity Toxins Tremor Tremor - chemically induced Tremor - pathology
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