Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing

Abstract Background Chronic nonhealing wound is a multifactorial complication of diabetes that results specifically as a consequence of impaired angiogenesis and currently lacks in effective treatments. Although a stem cell–based therapy may provide a novel treatment to augment diabetic wound healin...

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Veröffentlicht in:	The Journal of surgical research 2017-09, Vol.217, p.63-74
Hauptverfasser:	Kaisang, Lin, MD, Siyu, Wang, BS, Lijun, Fan, MD, Daoyan, Pan, MD, Xian, Cory J., PhD, Jie, Shen, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Adipose-derived stem cells Angiogenesis Animals Biomarkers - metabolism Diabetes Mellitus, Experimental Excipients Hydrogel Hydrogels Ki-67 Antigen - metabolism Male Neovascularization, Physiologic Poloxamer Rats, Sprague-Dawley Stem Cell Transplantation - methods Surgery Transforming Growth Factor beta1 - metabolism Transplantation, Homologous Vascular Endothelial Growth Factor A - metabolism Wound Healing
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