Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities

•Human iPSC system reflecting the “neuron-first, glia-second” differentiation pattern.•IL6 increases astrocyte and decreased neuron density in this human iPSC-based system.•Luteolin attenuates IL6-mediated neural changes in human iPSC-derived aggregates. Maternal infection during pregnancy increases...

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Veröffentlicht in:	Neuroscience letters 2017-07, Vol.653, p.296-301
Hauptverfasser:	Zuiki, Masashi, Chiyonobu, Tomohiro, Yoshida, Michiko, Maeda, Hiroshi, Yamashita, Satoshi, Kidowaki, Satoshi, Hasegawa, Tatsuji, Gotoh, Hitoshi, Nomura, Tadashi, Ono, Katsuhiko, Hosoi, Hajime, Morimoto, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism spectrum disorder Female Flavonoid Gliosis - drug therapy Gliosis - metabolism Humans Induced pluripotent stem cell Induced Pluripotent Stem Cells - metabolism Interleukin-6 Interleukin-6 - metabolism Luteolin Luteolin - pharmacology Maternal immune activation Neurodevelopmental Disorders - prevention & control Pregnancy Pregnancy Complications - drug therapy Pregnancy Complications - immunology STAT3 Transcription Factor - drug effects STAT3 Transcription Factor - metabolism
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