A Novel Interacting Protein SERP1 Regulates the N‐Linked Glycosylation and Function of GLP‐1 Receptor in the Liver

ABSTRACT Glucagon‐like peptide 1 (GLP‐1) exerts multiple effects on metabolism through its receptor, GLP‐1R, in the liver. Activation and transduction of GLP‐1R require complex interactions of largely unknown accessory proteins, and these processes are crucial to the response to endoplasmic reticulu...

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Veröffentlicht in:	Journal of cellular biochemistry 2017-11, Vol.118 (11), p.3616-3626
Hauptverfasser:	Xiao, Yuanyuan, Han, Junfeng, Wang, Qianqian, Mao, Yueqin, Wei, Meilin, Jia, Weiping, Wei, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Activation AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Endoplasmic reticulum Endoplasmic Reticulum Stress G PROTEIN‐COUPLED RECEPTOR Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide-1 Receptor - genetics Glucagon-Like Peptide-1 Receptor - metabolism GLUCAGON‐LIKE PEPTIDE 1 RECEPTOR GLYCOSYLATION HEK293 Cells Humans Hybrid systems Immunoprecipitation Liver Liver - metabolism Male Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Metabolism Mice Mice, Obese Proteins Stress Stresses STRESS‐ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 1 Tunicamycin Tunicamycin - pharmacology Two-Hybrid System Techniques Ubiquitin Yeast
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