In Vitro Evaluation of Pediatric Hollow‐Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach
The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a B...
Gespeichert in:
| Veröffentlicht in: | Artificial organs 2017-09, Vol.41 (9), p.865-874 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 874 |
|---|---|
| container_issue | 9 |
| container_start_page | 865 |
| container_title | Artificial organs |
| container_volume | 41 |
| creator | Wang, Shigang Caneo, Luiz F. Jatene, Marcelo B. Jatene, Fábio B. Cestari, Idagene A. Kunselman, Allen R. Ündar, Akif |
| description | The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a Braile Infant oxygenator or a Maquet Quadrox‐I Pediatric oxygenator without integrated arterial filter (parallel arrangement), 1/4 in. ID tubing A‐V loop, and a 12‐Fr arterial cannula, primed with lactated Ringer's solution and packed red blood cells. Trials were conducted at flow rates ranging from 500 to 2000 mL/min (500 mL/min increment) at 35°C and 28°C. Real‐time pressure and flow data were recorded using a custom‐based data acquisition system. For GME testing, 5 cc of air was manually injected into the venous line. GME were recorded using the Emboli Detection and Classification Quantifier (EDAC) System. An additional experiment using a separate arterial filter was conducted. There was no difference in the mean circuit pressure, pressure drop, total hemodynamic energy level, and energy loss between the two oxygenators. The venous line pressures were higher in the Braile than in the Quadrox group during all trials (P |
| doi_str_mv | 10.1111/aor.12912 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1908431161</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1908431161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3192-fffd760583001eae602e7e991ecb4a30f5b32f5ed26f4e04fedc2c13417f72803</originalsourceid><addsrcrecordid>eNpdkc1uEzEUhS0EoqGw4AWQJTbdTHNtz0_MLqraJlKjVIhW7EYez3Vx5bGDZ4aSHY_Q1-nr9EnqpIUF3vjK9zu-Pj6EfGRwzNKaqhCPGZeMvyITVvAiY4XMX5MJsBKyosy_H5B3fX8LAFUO5VtywGeFrAoJE_Kw9PTaDjHQ01_KjWqwwdNg6CW2Vg3RaroIzoW7xz_3Z7bBSFfYNVF5pOvf2xv0agixp0mzwC60W6-6JLnEaELslNdIlW_pueoxjD1dWR1D0gdn6SI1nPU3X-jc06UfMPr9cOXoanSD1bg7m-7r1vbabhKt4pbON5sYlP7xnrwxyvX44WU_JFdnp99OFtnF-nx5Mr_ItGCSZ8aYtiqhmAkAhgpL4FihlAx1kysBpmgENwW2vDQ5Qm6w1VwzkbPKVHwG4pAcPd-bxv4csR_qLj0HnUufkEzVTMIsF4yVLKGf_0Nvw5h8uR0lpKwqDjvq0ws1Nh229SbaLhmr_4aSgOkzcGcdbv_1GdS7tOuUdr1Pu56vv-4L8QS_RKEb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1939977201</pqid></control><display><type>article</type><title>In Vitro Evaluation of Pediatric Hollow‐Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Wang, Shigang ; Caneo, Luiz F. ; Jatene, Marcelo B. ; Jatene, Fábio B. ; Cestari, Idagene A. ; Kunselman, Allen R. ; Ündar, Akif</creator><creatorcontrib>Wang, Shigang ; Caneo, Luiz F. ; Jatene, Marcelo B. ; Jatene, Fábio B. ; Cestari, Idagene A. ; Kunselman, Allen R. ; Ündar, Akif</creatorcontrib><description>The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a Braile Infant oxygenator or a Maquet Quadrox‐I Pediatric oxygenator without integrated arterial filter (parallel arrangement), 1/4 in. ID tubing A‐V loop, and a 12‐Fr arterial cannula, primed with lactated Ringer's solution and packed red blood cells. Trials were conducted at flow rates ranging from 500 to 2000 mL/min (500 mL/min increment) at 35°C and 28°C. Real‐time pressure and flow data were recorded using a custom‐based data acquisition system. For GME testing, 5 cc of air was manually injected into the venous line. GME were recorded using the Emboli Detection and Classification Quantifier (EDAC) System. An additional experiment using a separate arterial filter was conducted. There was no difference in the mean circuit pressure, pressure drop, total hemodynamic energy level, and energy loss between the two oxygenators. The venous line pressures were higher in the Braile than in the Quadrox group during all trials (P <0.01). GME count and volume at pre‐/post oxygenator and pre‐cannula sites in the Quadrox were lower than the Braile group at high flow rates (P < 0.05). In the additional experiment, an arterial filter captured a significant number of microemboli at all flow rates. The Braile Infant oxygenator has a matched hemodynamic characteristic with the Quadrox‐i Pediatric oxygenator. The Quadrox‐i has a better GME handling ability compared with the Braile Infant oxygenator. Regardless of type of oxygenator an additional arterial filter decreases the number of GME.</description><identifier>ISSN: 0160-564X</identifier><identifier>EISSN: 1525-1594</identifier><identifier>DOI: 10.1111/aor.12912</identifier><identifier>PMID: 28597590</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Arteries ; Cardiopulmonary bypass ; Cardiopulmonary Bypass - adverse effects ; Child ; Circuits ; Computer simulation ; Data acquisition ; Embolism, Air - etiology ; Embolism, Air - prevention & control ; Energy ; Energy loss ; Equipment Design ; Erythrocytes ; Gaseous microemboli ; Gases - blood ; Handling ; Heart surgery ; Hemodynamics ; Hollow fiber membrane oxygenator ; Hollow fiber membranes ; Humans ; In vitro methods and tests ; In Vitro Techniques ; Interdisciplinary Research ; Medical materials ; Models, Cardiovascular ; Oxygenators, Membrane - adverse effects ; Pediatrics ; Pressure ; Pressure drop ; Surgical apparatus & instruments ; Tubes</subject><ispartof>Artificial organs, 2017-09, Vol.41 (9), p.865-874</ispartof><rights>2017 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3192-fffd760583001eae602e7e991ecb4a30f5b32f5ed26f4e04fedc2c13417f72803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faor.12912$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faor.12912$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28597590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shigang</creatorcontrib><creatorcontrib>Caneo, Luiz F.</creatorcontrib><creatorcontrib>Jatene, Marcelo B.</creatorcontrib><creatorcontrib>Jatene, Fábio B.</creatorcontrib><creatorcontrib>Cestari, Idagene A.</creatorcontrib><creatorcontrib>Kunselman, Allen R.</creatorcontrib><creatorcontrib>Ündar, Akif</creatorcontrib><title>In Vitro Evaluation of Pediatric Hollow‐Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach</title><title>Artificial organs</title><addtitle>Artif Organs</addtitle><description>The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a Braile Infant oxygenator or a Maquet Quadrox‐I Pediatric oxygenator without integrated arterial filter (parallel arrangement), 1/4 in. ID tubing A‐V loop, and a 12‐Fr arterial cannula, primed with lactated Ringer's solution and packed red blood cells. Trials were conducted at flow rates ranging from 500 to 2000 mL/min (500 mL/min increment) at 35°C and 28°C. Real‐time pressure and flow data were recorded using a custom‐based data acquisition system. For GME testing, 5 cc of air was manually injected into the venous line. GME were recorded using the Emboli Detection and Classification Quantifier (EDAC) System. An additional experiment using a separate arterial filter was conducted. There was no difference in the mean circuit pressure, pressure drop, total hemodynamic energy level, and energy loss between the two oxygenators. The venous line pressures were higher in the Braile than in the Quadrox group during all trials (P <0.01). GME count and volume at pre‐/post oxygenator and pre‐cannula sites in the Quadrox were lower than the Braile group at high flow rates (P < 0.05). In the additional experiment, an arterial filter captured a significant number of microemboli at all flow rates. The Braile Infant oxygenator has a matched hemodynamic characteristic with the Quadrox‐i Pediatric oxygenator. The Quadrox‐i has a better GME handling ability compared with the Braile Infant oxygenator. Regardless of type of oxygenator an additional arterial filter decreases the number of GME.</description><subject>Arteries</subject><subject>Cardiopulmonary bypass</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Child</subject><subject>Circuits</subject><subject>Computer simulation</subject><subject>Data acquisition</subject><subject>Embolism, Air - etiology</subject><subject>Embolism, Air - prevention & control</subject><subject>Energy</subject><subject>Energy loss</subject><subject>Equipment Design</subject><subject>Erythrocytes</subject><subject>Gaseous microemboli</subject><subject>Gases - blood</subject><subject>Handling</subject><subject>Heart surgery</subject><subject>Hemodynamics</subject><subject>Hollow fiber membrane oxygenator</subject><subject>Hollow fiber membranes</subject><subject>Humans</subject><subject>In vitro methods and tests</subject><subject>In Vitro Techniques</subject><subject>Interdisciplinary Research</subject><subject>Medical materials</subject><subject>Models, Cardiovascular</subject><subject>Oxygenators, Membrane - adverse effects</subject><subject>Pediatrics</subject><subject>Pressure</subject><subject>Pressure drop</subject><subject>Surgical apparatus & instruments</subject><subject>Tubes</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1uEzEUhS0EoqGw4AWQJTbdTHNtz0_MLqraJlKjVIhW7EYez3Vx5bGDZ4aSHY_Q1-nr9EnqpIUF3vjK9zu-Pj6EfGRwzNKaqhCPGZeMvyITVvAiY4XMX5MJsBKyosy_H5B3fX8LAFUO5VtywGeFrAoJE_Kw9PTaDjHQ01_KjWqwwdNg6CW2Vg3RaroIzoW7xz_3Z7bBSFfYNVF5pOvf2xv0agixp0mzwC60W6-6JLnEaELslNdIlW_pueoxjD1dWR1D0gdn6SI1nPU3X-jc06UfMPr9cOXoanSD1bg7m-7r1vbabhKt4pbON5sYlP7xnrwxyvX44WU_JFdnp99OFtnF-nx5Mr_ItGCSZ8aYtiqhmAkAhgpL4FihlAx1kysBpmgENwW2vDQ5Qm6w1VwzkbPKVHwG4pAcPd-bxv4csR_qLj0HnUufkEzVTMIsF4yVLKGf_0Nvw5h8uR0lpKwqDjvq0ws1Nh229SbaLhmr_4aSgOkzcGcdbv_1GdS7tOuUdr1Pu56vv-4L8QS_RKEb</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Wang, Shigang</creator><creator>Caneo, Luiz F.</creator><creator>Jatene, Marcelo B.</creator><creator>Jatene, Fábio B.</creator><creator>Cestari, Idagene A.</creator><creator>Kunselman, Allen R.</creator><creator>Ündar, Akif</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>In Vitro Evaluation of Pediatric Hollow‐Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach</title><author>Wang, Shigang ; Caneo, Luiz F. ; Jatene, Marcelo B. ; Jatene, Fábio B. ; Cestari, Idagene A. ; Kunselman, Allen R. ; Ündar, Akif</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3192-fffd760583001eae602e7e991ecb4a30f5b32f5ed26f4e04fedc2c13417f72803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Arteries</topic><topic>Cardiopulmonary bypass</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Child</topic><topic>Circuits</topic><topic>Computer simulation</topic><topic>Data acquisition</topic><topic>Embolism, Air - etiology</topic><topic>Embolism, Air - prevention & control</topic><topic>Energy</topic><topic>Energy loss</topic><topic>Equipment Design</topic><topic>Erythrocytes</topic><topic>Gaseous microemboli</topic><topic>Gases - blood</topic><topic>Handling</topic><topic>Heart surgery</topic><topic>Hemodynamics</topic><topic>Hollow fiber membrane oxygenator</topic><topic>Hollow fiber membranes</topic><topic>Humans</topic><topic>In vitro methods and tests</topic><topic>In Vitro Techniques</topic><topic>Interdisciplinary Research</topic><topic>Medical materials</topic><topic>Models, Cardiovascular</topic><topic>Oxygenators, Membrane - adverse effects</topic><topic>Pediatrics</topic><topic>Pressure</topic><topic>Pressure drop</topic><topic>Surgical apparatus & instruments</topic><topic>Tubes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shigang</creatorcontrib><creatorcontrib>Caneo, Luiz F.</creatorcontrib><creatorcontrib>Jatene, Marcelo B.</creatorcontrib><creatorcontrib>Jatene, Fábio B.</creatorcontrib><creatorcontrib>Cestari, Idagene A.</creatorcontrib><creatorcontrib>Kunselman, Allen R.</creatorcontrib><creatorcontrib>Ündar, Akif</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shigang</au><au>Caneo, Luiz F.</au><au>Jatene, Marcelo B.</au><au>Jatene, Fábio B.</au><au>Cestari, Idagene A.</au><au>Kunselman, Allen R.</au><au>Ündar, Akif</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Evaluation of Pediatric Hollow‐Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2017-09</date><risdate>2017</risdate><volume>41</volume><issue>9</issue><spage>865</spage><epage>874</epage><pages>865-874</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a Braile Infant oxygenator or a Maquet Quadrox‐I Pediatric oxygenator without integrated arterial filter (parallel arrangement), 1/4 in. ID tubing A‐V loop, and a 12‐Fr arterial cannula, primed with lactated Ringer's solution and packed red blood cells. Trials were conducted at flow rates ranging from 500 to 2000 mL/min (500 mL/min increment) at 35°C and 28°C. Real‐time pressure and flow data were recorded using a custom‐based data acquisition system. For GME testing, 5 cc of air was manually injected into the venous line. GME were recorded using the Emboli Detection and Classification Quantifier (EDAC) System. An additional experiment using a separate arterial filter was conducted. There was no difference in the mean circuit pressure, pressure drop, total hemodynamic energy level, and energy loss between the two oxygenators. The venous line pressures were higher in the Braile than in the Quadrox group during all trials (P <0.01). GME count and volume at pre‐/post oxygenator and pre‐cannula sites in the Quadrox were lower than the Braile group at high flow rates (P < 0.05). In the additional experiment, an arterial filter captured a significant number of microemboli at all flow rates. The Braile Infant oxygenator has a matched hemodynamic characteristic with the Quadrox‐i Pediatric oxygenator. The Quadrox‐i has a better GME handling ability compared with the Braile Infant oxygenator. Regardless of type of oxygenator an additional arterial filter decreases the number of GME.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28597590</pmid><doi>10.1111/aor.12912</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-564X |
| ispartof | Artificial organs, 2017-09, Vol.41 (9), p.865-874 |
| issn | 0160-564X 1525-1594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1908431161 |
| source | MEDLINE; Wiley Online Library |
| subjects | Arteries Cardiopulmonary bypass Cardiopulmonary Bypass - adverse effects Child Circuits Computer simulation Data acquisition Embolism, Air - etiology Embolism, Air - prevention & control Energy Energy loss Equipment Design Erythrocytes Gaseous microemboli Gases - blood Handling Heart surgery Hemodynamics Hollow fiber membrane oxygenator Hollow fiber membranes Humans In vitro methods and tests In Vitro Techniques Interdisciplinary Research Medical materials Models, Cardiovascular Oxygenators, Membrane - adverse effects Pediatrics Pressure Pressure drop Surgical apparatus & instruments Tubes |
| title | In Vitro Evaluation of Pediatric Hollow‐Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T15%3A37%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vitro%20Evaluation%20of%20Pediatric%20Hollow%E2%80%90Fiber%20Membrane%20Oxygenators%20on%20Hemodynamic%20Performance%20and%20Gaseous%20Microemboli%20Handling:%20An%20International%20Multicenter/Multidisciplinary%20Approach&rft.jtitle=Artificial%20organs&rft.au=Wang,%20Shigang&rft.date=2017-09&rft.volume=41&rft.issue=9&rft.spage=865&rft.epage=874&rft.pages=865-874&rft.issn=0160-564X&rft.eissn=1525-1594&rft_id=info:doi/10.1111/aor.12912&rft_dat=%3Cproquest_pubme%3E1908431161%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1939977201&rft_id=info:pmid/28597590&rfr_iscdi=true |