Potential Application of Nanoemulsions for Skin Delivery of Pomegranate Peel Polyphenols
Pomegranate peel and seeds have demonstrated to possess antioxidant compounds with potential application to protect the skin against the ultraviolet radiation damage. However, the photoprotection activity is dependent on the amount of these compounds that reach the viable skin layers. In this paper,...
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| Veröffentlicht in: | AAPS PharmSciTech 2017-11, Vol.18 (8), p.3307-3314 |
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| creator | Baccarin, Thaisa Lemos-Senna, Elenara |
| description | Pomegranate peel and seeds have demonstrated to possess antioxidant compounds with potential application to protect the skin against the ultraviolet radiation damage. However, the photoprotection activity is dependent on the amount of these compounds that reach the viable skin layers. In this paper, we describe the
in vitro
skin permeation and retention of the major pomegranate peel polyphenols using Franz diffusion cells, after entrapping a ethyl acetate fraction (EAF) from
Punica granatum
peel extract into nanoemulsions (NEs) prepared with pomegranate seed oil (PSO) or medium chain triglyceride oil (MCT). The
in vitro
skin permeation of gallic acid (GA), ellagic acid (EA), and punicalagin (PC) was evaluated using a HPLC-DAD validated method. After 8 h of skin permeation, all polyphenol compounds were mostly retained in the skin and did not reach the receptor compartment. However, a 2.2-fold enhancement of the retained amount of gallic acid in the
stratum corneum
was verified after EAF-loaded NEs are applied, when compared with the free EAF. GA and EA were delivered to the viable epidermis and dermis only when nanoemulsions were applied onto the skin. The mean retained amounts of GA and EA in the EP and DE after applying the EAF-loaded PSO-NE were 1.78 and 1.36 μg cm
−2
and 1.10 and 0.97 μg cm
−2
, respectively. Similar values were obtained after applying the EAF-loaded MCT-NE. The skin permeation results were supported by the confocal microscopy images. These results evidenced the promising application of nanoemulsions to deliver the pomegranate polyphenols into the deeper skin layers. |
| doi_str_mv | 10.1208/s12249-017-0818-x |
| format | Article |
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in vitro
skin permeation and retention of the major pomegranate peel polyphenols using Franz diffusion cells, after entrapping a ethyl acetate fraction (EAF) from
Punica granatum
peel extract into nanoemulsions (NEs) prepared with pomegranate seed oil (PSO) or medium chain triglyceride oil (MCT). The
in vitro
skin permeation of gallic acid (GA), ellagic acid (EA), and punicalagin (PC) was evaluated using a HPLC-DAD validated method. After 8 h of skin permeation, all polyphenol compounds were mostly retained in the skin and did not reach the receptor compartment. However, a 2.2-fold enhancement of the retained amount of gallic acid in the
stratum corneum
was verified after EAF-loaded NEs are applied, when compared with the free EAF. GA and EA were delivered to the viable epidermis and dermis only when nanoemulsions were applied onto the skin. The mean retained amounts of GA and EA in the EP and DE after applying the EAF-loaded PSO-NE were 1.78 and 1.36 μg cm
−2
and 1.10 and 0.97 μg cm
−2
, respectively. Similar values were obtained after applying the EAF-loaded MCT-NE. The skin permeation results were supported by the confocal microscopy images. These results evidenced the promising application of nanoemulsions to deliver the pomegranate polyphenols into the deeper skin layers.</description><identifier>ISSN: 1530-9932</identifier><identifier>EISSN: 1530-9932</identifier><identifier>DOI: 10.1208/s12249-017-0818-x</identifier><identifier>PMID: 28597364</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject><![CDATA[Animals ; Antioxidants - administration & dosage ; Antioxidants - isolation & purification ; Antioxidants - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Drug Delivery Systems - methods ; Emulsions ; Humans ; Nanoparticles - administration & dosage ; Nanoparticles - metabolism ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - administration & dosage ; Plant Extracts - isolation & purification ; Plant Extracts - metabolism ; Polyphenols - administration & dosage ; Polyphenols - isolation & purification ; Polyphenols - metabolism ; Punicaceae ; Research Article ; Seeds ; Skin Absorption - drug effects ; Skin Absorption - physiology ; Swine]]></subject><ispartof>AAPS PharmSciTech, 2017-11, Vol.18 (8), p.3307-3314</ispartof><rights>American Association of Pharmaceutical Scientists 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-f68b6685673c234f3a8d20c0902b8357797b8c8c8a5c6168cffa5bc91e5552e63</citedby><cites>FETCH-LOGICAL-c344t-f68b6685673c234f3a8d20c0902b8357797b8c8c8a5c6168cffa5bc91e5552e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1208/s12249-017-0818-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1208/s12249-017-0818-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28597364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baccarin, Thaisa</creatorcontrib><creatorcontrib>Lemos-Senna, Elenara</creatorcontrib><title>Potential Application of Nanoemulsions for Skin Delivery of Pomegranate Peel Polyphenols</title><title>AAPS PharmSciTech</title><addtitle>AAPS PharmSciTech</addtitle><addtitle>AAPS PharmSciTech</addtitle><description>Pomegranate peel and seeds have demonstrated to possess antioxidant compounds with potential application to protect the skin against the ultraviolet radiation damage. However, the photoprotection activity is dependent on the amount of these compounds that reach the viable skin layers. In this paper, we describe the
in vitro
skin permeation and retention of the major pomegranate peel polyphenols using Franz diffusion cells, after entrapping a ethyl acetate fraction (EAF) from
Punica granatum
peel extract into nanoemulsions (NEs) prepared with pomegranate seed oil (PSO) or medium chain triglyceride oil (MCT). The
in vitro
skin permeation of gallic acid (GA), ellagic acid (EA), and punicalagin (PC) was evaluated using a HPLC-DAD validated method. After 8 h of skin permeation, all polyphenol compounds were mostly retained in the skin and did not reach the receptor compartment. However, a 2.2-fold enhancement of the retained amount of gallic acid in the
stratum corneum
was verified after EAF-loaded NEs are applied, when compared with the free EAF. GA and EA were delivered to the viable epidermis and dermis only when nanoemulsions were applied onto the skin. The mean retained amounts of GA and EA in the EP and DE after applying the EAF-loaded PSO-NE were 1.78 and 1.36 μg cm
−2
and 1.10 and 0.97 μg cm
−2
, respectively. Similar values were obtained after applying the EAF-loaded MCT-NE. The skin permeation results were supported by the confocal microscopy images. These results evidenced the promising application of nanoemulsions to deliver the pomegranate polyphenols into the deeper skin layers.</description><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Drug Delivery Systems - methods</subject><subject>Emulsions</subject><subject>Humans</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - metabolism</subject><subject>Polyphenols - administration & dosage</subject><subject>Polyphenols - isolation & purification</subject><subject>Polyphenols - metabolism</subject><subject>Punicaceae</subject><subject>Research Article</subject><subject>Seeds</subject><subject>Skin Absorption - drug effects</subject><subject>Skin Absorption - physiology</subject><subject>Swine</subject><issn>1530-9932</issn><issn>1530-9932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxTAQhoMoXo4-gBvp0k01l6ZNluIdRA-o4C6kcarVNKlJK-e8vTlUxZVkMZnJNz_kQ2if4CNCsTiOhNJC5phUORZE5Is1tE04w7mUjK7_uW-hnRjfMKaMSLaJtqjgsmJlsY2e5n4AN7TaZid9b1ujh9a7zDfZrXYeutHG1Mes8SG7f29ddga2_YSwXCFz38FL0E4PkM0BbBrYZf8Kztu4izYabSPsfdcZerw4fzi9ym_uLq9PT25yw4piyJtS1GUpeFkxQ1nRMC2eKTZYYloLxqtKVrUw6WhuSlIK0zSa10YS4JxTKNkMHU65ffAfI8RBdW00YK124MeoiMSiYIQwnlAyoSb4GAM0qg9tp8NSEaxWQtUkVCWhaiVULdLOwXf8WHfw_LvxYzABdAJienIvENSbH4NLX_4n9QsHyIGY</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Baccarin, Thaisa</creator><creator>Lemos-Senna, Elenara</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171101</creationdate><title>Potential Application of Nanoemulsions for Skin Delivery of Pomegranate Peel Polyphenols</title><author>Baccarin, Thaisa ; Lemos-Senna, Elenara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-f68b6685673c234f3a8d20c0902b8357797b8c8c8a5c6168cffa5bc91e5552e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - metabolism</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Drug Delivery Systems - methods</topic><topic>Emulsions</topic><topic>Humans</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - metabolism</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - metabolism</topic><topic>Polyphenols - administration & dosage</topic><topic>Polyphenols - isolation & purification</topic><topic>Polyphenols - metabolism</topic><topic>Punicaceae</topic><topic>Research Article</topic><topic>Seeds</topic><topic>Skin Absorption - drug effects</topic><topic>Skin Absorption - physiology</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baccarin, Thaisa</creatorcontrib><creatorcontrib>Lemos-Senna, Elenara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AAPS PharmSciTech</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baccarin, Thaisa</au><au>Lemos-Senna, Elenara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Application of Nanoemulsions for Skin Delivery of Pomegranate Peel Polyphenols</atitle><jtitle>AAPS PharmSciTech</jtitle><stitle>AAPS PharmSciTech</stitle><addtitle>AAPS PharmSciTech</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>18</volume><issue>8</issue><spage>3307</spage><epage>3314</epage><pages>3307-3314</pages><issn>1530-9932</issn><eissn>1530-9932</eissn><abstract>Pomegranate peel and seeds have demonstrated to possess antioxidant compounds with potential application to protect the skin against the ultraviolet radiation damage. However, the photoprotection activity is dependent on the amount of these compounds that reach the viable skin layers. In this paper, we describe the
in vitro
skin permeation and retention of the major pomegranate peel polyphenols using Franz diffusion cells, after entrapping a ethyl acetate fraction (EAF) from
Punica granatum
peel extract into nanoemulsions (NEs) prepared with pomegranate seed oil (PSO) or medium chain triglyceride oil (MCT). The
in vitro
skin permeation of gallic acid (GA), ellagic acid (EA), and punicalagin (PC) was evaluated using a HPLC-DAD validated method. After 8 h of skin permeation, all polyphenol compounds were mostly retained in the skin and did not reach the receptor compartment. However, a 2.2-fold enhancement of the retained amount of gallic acid in the
stratum corneum
was verified after EAF-loaded NEs are applied, when compared with the free EAF. GA and EA were delivered to the viable epidermis and dermis only when nanoemulsions were applied onto the skin. The mean retained amounts of GA and EA in the EP and DE after applying the EAF-loaded PSO-NE were 1.78 and 1.36 μg cm
−2
and 1.10 and 0.97 μg cm
−2
, respectively. Similar values were obtained after applying the EAF-loaded MCT-NE. The skin permeation results were supported by the confocal microscopy images. These results evidenced the promising application of nanoemulsions to deliver the pomegranate polyphenols into the deeper skin layers.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28597364</pmid><doi>10.1208/s12249-017-0818-x</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antioxidants - administration & dosage Antioxidants - isolation & purification Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Drug Delivery Systems - methods Emulsions Humans Nanoparticles - administration & dosage Nanoparticles - metabolism Pharmacology/Toxicology Pharmacy Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - metabolism Polyphenols - administration & dosage Polyphenols - isolation & purification Polyphenols - metabolism Punicaceae Research Article Seeds Skin Absorption - drug effects Skin Absorption - physiology Swine |
| title | Potential Application of Nanoemulsions for Skin Delivery of Pomegranate Peel Polyphenols |
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