Effect of Temperature on the Kinetics of the Activation of Treosulfan and Hydrolytic Decomposition of Its Active Epoxy Derivatives

Treosulfan (TREO) is a prodrug applied in the treatment of ovarian cancer and a myeloablative conditioning prior to stem cell transplantation. A sequential activation of TREO to intermediate monoepoxide (S,S-EBDM) and then to (2S,3S)-1,2:3,4-diepoxybutane (S,S-DEB) involves a nonenzymatic intramolec...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of pharmaceutical sciences 2017-10, Vol.106 (10), p.3156-3160
Hauptverfasser:	Romański, Michał, Mikołajewski, Jakub, Główka, Franciszek K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Busulfan - analogs & derivatives Busulfan - chemistry HPLC Hydrogen-Ion Concentration Hydrolysis - drug effects Kinetics mathematical model metabolite kinetics Osmolar Concentration pharmacokinetics prodrugs Prodrugs - chemistry Temperature
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!