Bone morphogenetic protein signaling governs biliary‐driven liver regeneration in zebrafish through tbx2b and id2a

Upon mild liver injury, new hepatocytes originate from preexisting hepatocytes. However, if hepatocyte proliferation is impaired, a manifestation of severe liver injury, biliary epithelial cells (BECs) contribute to new hepatocytes through BEC dedifferentiation into liver progenitor cells (LPCs), al...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2017-11, Vol.66 (5), p.1616-1630
Hauptverfasser:	Choi, Tae‐Young, Khaliq, Mehwish, Tsurusaki, Shinya, Ninov, Nikolay, Stainier, Didier Y.R., Tanaka, Minoru, Shin, Donghun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Bone morphogenetic protein 2 Bone Morphogenetic Proteins - metabolism Cell Differentiation Cell Proliferation Danio rerio Epithelial cells Gene regulation Hepatocytes Hepatocytes - cytology Hepatology Inhibitor of Differentiation Protein 2 - metabolism Liver Liver Regeneration Regeneration Smad5 protein Stem cells T-Box Domain Proteins - metabolism Zebrafish Zebrafish Proteins - metabolism
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