The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen improve ANP levels and decrease nuclear translocation of NF-kB in estrogen-deficient rats

The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen are used for the treatment of osteoporosis and cancer, respectively, in women. The impairment of both the Atrial Natriuretic Peptide (ANP) cell signaling system and the translocation of nuclear factor-kappa B (NF-kB) to the...

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Veröffentlicht in:	Pharmacological reports 2017-08, Vol.69 (4), p.798-805
Hauptverfasser:	Lamas, Aline Z., Nascimento, Andrews M., Medeiros, Ana Raquel S., Caliman, Izabela F., Dalpiaz, Polyana L.M., Firmes, Luciana B., Sousa, Glauciene J., Oliveira, Phablo Wendell C., Andrade, Tadeu U., Reis, Adelina M., Gouvea, Sônia A., Bissoli, Nazaré S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals ANP Atrial Natriuretic Factor - genetics Atrial Natriuretic Factor - metabolism Body Weight Drug Safety and Pharmacovigilance Estrogens - metabolism Female Heart Hemodynamics - drug effects Myocardium - metabolism NF-kappa B - metabolism NF-kB Organ Size - drug effects Original Article Ovariectomy Pharmacotherapy Pharmacy Raloxifene Raloxifene Hydrochloride - pharmacology Rats Selective Estrogen Receptor Modulators - pharmacology SERMs Tamoxifen Tamoxifen - pharmacology Uterus - drug effects
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