The IGF‐1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching
Skeletal muscle mass is an important trait in the animal industry. We previously reported an age‐dependent downregulation of the insulin‐like growth factor 1 (IGF‐1)/Akt/S6 pathway, major protein synthesis pathway, in chicken breast muscle after 1 week of age, despite a continuous increase of breast...
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| Veröffentlicht in: | Animal science journal 2017-11, Vol.88 (11), p.1779-1787 |
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| creator | Saneyasu, Takaoki Tsuchihashi, Tatsuya Kitashiro, Ayana Tsuchii, Nami Kimura, Sayaka Honda, Kazuhisa Kamisoyama, Hiroshi |
| description | Skeletal muscle mass is an important trait in the animal industry. We previously reported an age‐dependent downregulation of the insulin‐like growth factor 1 (IGF‐1)/Akt/S6 pathway, major protein synthesis pathway, in chicken breast muscle after 1 week of age, despite a continuous increase of breast muscle weight. Myosin heavy chain (HC), a major protein in muscle fiber, has several isoforms depending on chicken skeletal muscle types. HC I (fast‐twitch glycolytic type) is known to be expressed in adult chicken breast muscle. However, little is known about the changes in the expression levels of protein synthesis‐related factors and HC isoforms in perihatching chicken muscle. In the present study, protein synthesis‐related factors, such as IGF‐1 messenger RNA (mRNA) levels, phosphorylation of Akt, and phosphorylated S6 content, increased in an age‐dependent manner after post‐hatch day (D) 0. The mRNA levels of HC I, III and V (fast‐twitch glycolytic type) dramatically increased after D0. The increase ratio of breast muscle weight was approximately 1100% from D0 to D7. To our knowledge, these findings provide the first evidence that upregulation of protein synthesis pathway and transcription of fast twitch glycolytic HC isoforms play critical roles in the increase of chicken breast muscle weight during the first week after hatching. |
| doi_str_mv | 10.1111/asj.12847 |
| format | Article |
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We previously reported an age‐dependent downregulation of the insulin‐like growth factor 1 (IGF‐1)/Akt/S6 pathway, major protein synthesis pathway, in chicken breast muscle after 1 week of age, despite a continuous increase of breast muscle weight. Myosin heavy chain (HC), a major protein in muscle fiber, has several isoforms depending on chicken skeletal muscle types. HC I (fast‐twitch glycolytic type) is known to be expressed in adult chicken breast muscle. However, little is known about the changes in the expression levels of protein synthesis‐related factors and HC isoforms in perihatching chicken muscle. In the present study, protein synthesis‐related factors, such as IGF‐1 messenger RNA (mRNA) levels, phosphorylation of Akt, and phosphorylated S6 content, increased in an age‐dependent manner after post‐hatch day (D) 0. The mRNA levels of HC I, III and V (fast‐twitch glycolytic type) dramatically increased after D0. The increase ratio of breast muscle weight was approximately 1100% from D0 to D7. To our knowledge, these findings provide the first evidence that upregulation of protein synthesis pathway and transcription of fast twitch glycolytic HC isoforms play critical roles in the increase of chicken breast muscle weight during the first week after hatching.</description><identifier>ISSN: 1344-3941</identifier><identifier>EISSN: 1740-0929</identifier><identifier>DOI: 10.1111/asj.12847</identifier><identifier>PMID: 28594135</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Age ; Aging - genetics ; Aging - metabolism ; AKT protein ; Animals ; Animals, Newborn - genetics ; Animals, Newborn - metabolism ; Breast muscle ; Chains ; Chickens ; Chickens - genetics ; Chickens - metabolism ; Female ; Gene Expression ; Glycolysis ; Hatching ; Insulin ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - metabolism ; Insulin-Like Growth Factor I - physiology ; Insulin-like growth factors ; Isoforms ; Male ; Muscle Proteins - genetics ; Muscle Proteins - metabolism ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - metabolism ; Musculoskeletal system ; Myosin ; myosin heavy chain ; Myosin Heavy Chains - genetics ; Myosin Heavy Chains - metabolism ; Organ Size - genetics ; Organ Size - physiology ; perihatching chick ; Phosphorylation ; Poultry ; Protein biosynthesis ; Protein Biosynthesis - genetics ; Protein Biosynthesis - physiology ; Protein Isoforms - metabolism ; Protein synthesis ; Proteins ; Proto-Oncogene Proteins c-akt - metabolism ; Proto-Oncogene Proteins c-akt - physiology ; Ribonucleic acid ; Ribosomal Protein S6 - metabolism ; Ribosomal Protein S6 - physiology ; RNA ; Signal Transduction - physiology ; Skeletal muscle ; Transcription ; Up-Regulation</subject><ispartof>Animal science journal, 2017-11, Vol.88 (11), p.1779-1787</ispartof><rights>2017 Japanese Society of Animal Science</rights><rights>2017 Japanese Society of Animal Science.</rights><rights>Copyright © 2017 Japanese Society of Animal Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4987-ad81fad3a35f1a3784c66d52e4a9113d554c0bf7b80eead048aec6217c411bc93</citedby><cites>FETCH-LOGICAL-c4987-ad81fad3a35f1a3784c66d52e4a9113d554c0bf7b80eead048aec6217c411bc93</cites><orcidid>0000-0002-6150-6916</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fasj.12847$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fasj.12847$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28594135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saneyasu, Takaoki</creatorcontrib><creatorcontrib>Tsuchihashi, Tatsuya</creatorcontrib><creatorcontrib>Kitashiro, Ayana</creatorcontrib><creatorcontrib>Tsuchii, Nami</creatorcontrib><creatorcontrib>Kimura, Sayaka</creatorcontrib><creatorcontrib>Honda, Kazuhisa</creatorcontrib><creatorcontrib>Kamisoyama, Hiroshi</creatorcontrib><title>The IGF‐1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching</title><title>Animal science journal</title><addtitle>Anim Sci J</addtitle><description>Skeletal muscle mass is an important trait in the animal industry. We previously reported an age‐dependent downregulation of the insulin‐like growth factor 1 (IGF‐1)/Akt/S6 pathway, major protein synthesis pathway, in chicken breast muscle after 1 week of age, despite a continuous increase of breast muscle weight. Myosin heavy chain (HC), a major protein in muscle fiber, has several isoforms depending on chicken skeletal muscle types. HC I (fast‐twitch glycolytic type) is known to be expressed in adult chicken breast muscle. However, little is known about the changes in the expression levels of protein synthesis‐related factors and HC isoforms in perihatching chicken muscle. In the present study, protein synthesis‐related factors, such as IGF‐1 messenger RNA (mRNA) levels, phosphorylation of Akt, and phosphorylated S6 content, increased in an age‐dependent manner after post‐hatch day (D) 0. The mRNA levels of HC I, III and V (fast‐twitch glycolytic type) dramatically increased after D0. The increase ratio of breast muscle weight was approximately 1100% from D0 to D7. To our knowledge, these findings provide the first evidence that upregulation of protein synthesis pathway and transcription of fast twitch glycolytic HC isoforms play critical roles in the increase of chicken breast muscle weight during the first week after hatching.</description><subject>Age</subject><subject>Aging - genetics</subject><subject>Aging - metabolism</subject><subject>AKT protein</subject><subject>Animals</subject><subject>Animals, Newborn - genetics</subject><subject>Animals, Newborn - metabolism</subject><subject>Breast muscle</subject><subject>Chains</subject><subject>Chickens</subject><subject>Chickens - genetics</subject><subject>Chickens - metabolism</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Glycolysis</subject><subject>Hatching</subject><subject>Insulin</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-Like Growth Factor I - physiology</subject><subject>Insulin-like growth factors</subject><subject>Isoforms</subject><subject>Male</subject><subject>Muscle Proteins - genetics</subject><subject>Muscle Proteins - metabolism</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Musculoskeletal system</subject><subject>Myosin</subject><subject>myosin heavy chain</subject><subject>Myosin Heavy Chains - genetics</subject><subject>Myosin Heavy Chains - metabolism</subject><subject>Organ Size - genetics</subject><subject>Organ Size - physiology</subject><subject>perihatching chick</subject><subject>Phosphorylation</subject><subject>Poultry</subject><subject>Protein biosynthesis</subject><subject>Protein Biosynthesis - genetics</subject><subject>Protein Biosynthesis - physiology</subject><subject>Protein Isoforms - metabolism</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Proto-Oncogene Proteins c-akt - physiology</subject><subject>Ribonucleic acid</subject><subject>Ribosomal Protein S6 - metabolism</subject><subject>Ribosomal Protein S6 - physiology</subject><subject>RNA</subject><subject>Signal Transduction - physiology</subject><subject>Skeletal muscle</subject><subject>Transcription</subject><subject>Up-Regulation</subject><issn>1344-3941</issn><issn>1740-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQxiMEoqVw4AXQSFzgkK4dO_-Oq4qWVpU4tJyjWWey8a4TL7bDkhuPwEPwZDwJbrdwqNS5zGjmN58-6UuSt5yd8lgL9JtTnlWyfJYc81KylNVZ_TzOQspU1JIfJa-83zDGy5rlL5OjrMrjVuTHye_bnuDy4vzPz198sdyGxU0BOwz9HmfAsQX6sXPkvbajB9vB2szKmjloBcNsvR6hJ_w-g-oxztrbzrrBAzqCKT6uJ4OBWog31Wu1pRH8lgwFNDBMXhmCdnJ6XEOINjrtfIA90RawC-SgxxDfxvXr5EWHxtObh36SfD3_dHv2Ob3-cnF5trxOlayrMsW24h22AkXecRRlJVVRtHlGEmvORZvnUrFVV64qRoQtkxWSKjJeKsn5StXiJPlw0N05-20iH5pBe0XG4Eh28g2vWSmyTFR36PtH6MZObozuIlUwLkReyEh9PFDKWe8ddc3O6QHd3HDW3EXXxOia--gi--5BcVoN1P4n_2UVgcUB2GtD89NKzfLm6iD5FyDWpfM</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Saneyasu, Takaoki</creator><creator>Tsuchihashi, Tatsuya</creator><creator>Kitashiro, Ayana</creator><creator>Tsuchii, Nami</creator><creator>Kimura, Sayaka</creator><creator>Honda, Kazuhisa</creator><creator>Kamisoyama, Hiroshi</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6150-6916</orcidid></search><sort><creationdate>201711</creationdate><title>The IGF‐1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching</title><author>Saneyasu, Takaoki ; Tsuchihashi, Tatsuya ; Kitashiro, Ayana ; Tsuchii, Nami ; Kimura, Sayaka ; Honda, Kazuhisa ; Kamisoyama, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4987-ad81fad3a35f1a3784c66d52e4a9113d554c0bf7b80eead048aec6217c411bc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aging - genetics</topic><topic>Aging - metabolism</topic><topic>AKT protein</topic><topic>Animals</topic><topic>Animals, Newborn - genetics</topic><topic>Animals, Newborn - metabolism</topic><topic>Breast muscle</topic><topic>Chains</topic><topic>Chickens</topic><topic>Chickens - genetics</topic><topic>Chickens - metabolism</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Glycolysis</topic><topic>Hatching</topic><topic>Insulin</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-Like Growth Factor I - physiology</topic><topic>Insulin-like growth factors</topic><topic>Isoforms</topic><topic>Male</topic><topic>Muscle Proteins - genetics</topic><topic>Muscle Proteins - metabolism</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Musculoskeletal system</topic><topic>Myosin</topic><topic>myosin heavy chain</topic><topic>Myosin Heavy Chains - genetics</topic><topic>Myosin Heavy Chains - metabolism</topic><topic>Organ Size - genetics</topic><topic>Organ Size - physiology</topic><topic>perihatching chick</topic><topic>Phosphorylation</topic><topic>Poultry</topic><topic>Protein biosynthesis</topic><topic>Protein Biosynthesis - genetics</topic><topic>Protein Biosynthesis - physiology</topic><topic>Protein Isoforms - metabolism</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Proto-Oncogene Proteins c-akt - physiology</topic><topic>Ribonucleic acid</topic><topic>Ribosomal Protein S6 - metabolism</topic><topic>Ribosomal Protein S6 - physiology</topic><topic>RNA</topic><topic>Signal Transduction - physiology</topic><topic>Skeletal muscle</topic><topic>Transcription</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saneyasu, Takaoki</creatorcontrib><creatorcontrib>Tsuchihashi, Tatsuya</creatorcontrib><creatorcontrib>Kitashiro, Ayana</creatorcontrib><creatorcontrib>Tsuchii, Nami</creatorcontrib><creatorcontrib>Kimura, Sayaka</creatorcontrib><creatorcontrib>Honda, Kazuhisa</creatorcontrib><creatorcontrib>Kamisoyama, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Animal science journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saneyasu, Takaoki</au><au>Tsuchihashi, Tatsuya</au><au>Kitashiro, Ayana</au><au>Tsuchii, Nami</au><au>Kimura, Sayaka</au><au>Honda, Kazuhisa</au><au>Kamisoyama, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The IGF‐1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching</atitle><jtitle>Animal science journal</jtitle><addtitle>Anim Sci J</addtitle><date>2017-11</date><risdate>2017</risdate><volume>88</volume><issue>11</issue><spage>1779</spage><epage>1787</epage><pages>1779-1787</pages><issn>1344-3941</issn><eissn>1740-0929</eissn><abstract>Skeletal muscle mass is an important trait in the animal industry. We previously reported an age‐dependent downregulation of the insulin‐like growth factor 1 (IGF‐1)/Akt/S6 pathway, major protein synthesis pathway, in chicken breast muscle after 1 week of age, despite a continuous increase of breast muscle weight. Myosin heavy chain (HC), a major protein in muscle fiber, has several isoforms depending on chicken skeletal muscle types. HC I (fast‐twitch glycolytic type) is known to be expressed in adult chicken breast muscle. However, little is known about the changes in the expression levels of protein synthesis‐related factors and HC isoforms in perihatching chicken muscle. In the present study, protein synthesis‐related factors, such as IGF‐1 messenger RNA (mRNA) levels, phosphorylation of Akt, and phosphorylated S6 content, increased in an age‐dependent manner after post‐hatch day (D) 0. The mRNA levels of HC I, III and V (fast‐twitch glycolytic type) dramatically increased after D0. The increase ratio of breast muscle weight was approximately 1100% from D0 to D7. To our knowledge, these findings provide the first evidence that upregulation of protein synthesis pathway and transcription of fast twitch glycolytic HC isoforms play critical roles in the increase of chicken breast muscle weight during the first week after hatching.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>28594135</pmid><doi>10.1111/asj.12847</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6150-6916</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Animal science journal, 2017-11, Vol.88 (11), p.1779-1787 |
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| subjects | Age Aging - genetics Aging - metabolism AKT protein Animals Animals, Newborn - genetics Animals, Newborn - metabolism Breast muscle Chains Chickens Chickens - genetics Chickens - metabolism Female Gene Expression Glycolysis Hatching Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - physiology Insulin-like growth factors Isoforms Male Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Musculoskeletal system Myosin myosin heavy chain Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Organ Size - genetics Organ Size - physiology perihatching chick Phosphorylation Poultry Protein biosynthesis Protein Biosynthesis - genetics Protein Biosynthesis - physiology Protein Isoforms - metabolism Protein synthesis Proteins Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-akt - physiology Ribonucleic acid Ribosomal Protein S6 - metabolism Ribosomal Protein S6 - physiology RNA Signal Transduction - physiology Skeletal muscle Transcription Up-Regulation |
| title | The IGF‐1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching |
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