CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target

is the most prevalent sexually transmitted bacterial infection worldwide and the leading cause of preventable blindness. Reports have emerged of treatment failure, suggesting a need to develop new antibiotics to battle infection. One possible candidate for a new treatment is the protease inhibitor J...

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Veröffentlicht in:	Future microbiology 2017-07, Vol.12 (9), p.817-829
Hauptverfasser:	Marsh, James W, Ong, Vanissa A, Lott, William B, Timms, Peter, Tyndall, Joel DA, Huston, Wilhelmina M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - metabolism Blindness Cell adhesion & migration Cell surface Chlamydia Chlamydia Infections - drug therapy Chlamydia Infections - microbiology Chlamydia trachomatis - drug effects Chlamydia trachomatis - enzymology Chlamydia trachomatis - metabolism Chlamydia trachomatis - pathogenicity DegP Dipeptides - therapeutic use Drug development E coli HtrA Humans Infections intracellular Localization Membrane proteins Models, Biological Models, Molecular Mutation Organophosphonates - therapeutic use Pathogens Peptides Physiology protease Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Proteinase inhibitors Proteins Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Therapeutic applications Virulence Virulence Factors - chemistry Virulence Factors - metabolism
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