Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women

The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based o...

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Veröffentlicht in:Phytotherapy research 2017-08, Vol.31 (8), p.1209-1214
Hauptverfasser: Kirichenko, T. V., Myasoedova, V. A., Orekhova, V. A., Ravani, A. L., Nikitina, N. A., Grechko, A. V., Sobenin, I. A., Orekhov, A. N.
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container_end_page 1214
container_issue 8
container_start_page 1209
container_title Phytotherapy research
container_volume 31
creator Kirichenko, T. V.
Myasoedova, V. A.
Orekhova, V. A.
Ravani, A. L.
Nikitina, N. A.
Grechko, A. V.
Sobenin, I. A.
Orekhov, A. N.
description The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima‐media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow‐up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima‐media thickness between the two groups was not statistically significant at follow‐up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. Copyright © 2017 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/ptr.5841
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V. ; Myasoedova, V. A. ; Orekhova, V. A. ; Ravani, A. L. ; Nikitina, N. A. ; Grechko, A. V. ; Sobenin, I. A. ; Orekhov, A. N.</creator><creatorcontrib>Kirichenko, T. V. ; Myasoedova, V. A. ; Orekhova, V. A. ; Ravani, A. L. ; Nikitina, N. A. ; Grechko, A. V. ; Sobenin, I. A. ; Orekhov, A. N.</creatorcontrib><description>The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima‐media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow‐up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima‐media thickness between the two groups was not statistically significant at follow‐up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. 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V.</au><au>Myasoedova, V. A.</au><au>Orekhova, V. A.</au><au>Ravani, A. L.</au><au>Nikitina, N. A.</au><au>Grechko, A. V.</au><au>Sobenin, I. A.</au><au>Orekhov, A. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2017-08</date><risdate>2017</risdate><volume>31</volume><issue>8</issue><spage>1209</spage><epage>1214</epage><pages>1209-1214</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima‐media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow‐up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima‐media thickness between the two groups was not statistically significant at follow‐up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. Copyright © 2017 John Wiley &amp; Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28593720</pmid><doi>10.1002/ptr.5841</doi><tpages>6</tpages></addata></record>
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subjects Adult
alpha-Tocopherol - therapeutic use
Arteriosclerosis
Ascorbic Acid - therapeutic use
Atherosclerosis
Atherosclerosis - prevention & control
beta Carotene - therapeutic use
Cardiovascular diseases
Carotid Intima-Media Thickness
climacteric syndrome
Double-Blind Method
Emotions
Female
Garlic
Green tea
Herbal medicine
Hormone replacement therapy
Humans
Low density lipoprotein
Menopause
Middle Aged
perimenopause
Perimenopause - drug effects
Phytoestrogens
Phytoestrogens - therapeutic use
phytoestrogen‐rich natural preparation
Phytotherapy
Prevention
Quality of Life
Seeds
Statistical analysis
Tea
title Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women
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