Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women
The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based o...
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creator | Kirichenko, T. V. Myasoedova, V. A. Orekhova, V. A. Ravani, A. L. Nikitina, N. A. Grechko, A. V. Sobenin, I. A. Orekhov, A. N. |
description | The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima‐media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow‐up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima‐media thickness between the two groups was not statistically significant at follow‐up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. Copyright © 2017 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/ptr.5841 |
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V. ; Myasoedova, V. A. ; Orekhova, V. A. ; Ravani, A. L. ; Nikitina, N. A. ; Grechko, A. V. ; Sobenin, I. A. ; Orekhov, A. N.</creator><creatorcontrib>Kirichenko, T. V. ; Myasoedova, V. A. ; Orekhova, V. A. ; Ravani, A. L. ; Nikitina, N. A. ; Grechko, A. V. ; Sobenin, I. A. ; Orekhov, A. N.</creatorcontrib><description>The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima‐media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow‐up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima‐media thickness between the two groups was not statistically significant at follow‐up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. Copyright © 2017 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5841</identifier><identifier>PMID: 28593720</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; alpha-Tocopherol - therapeutic use ; Arteriosclerosis ; Ascorbic Acid - therapeutic use ; Atherosclerosis ; Atherosclerosis - prevention & control ; beta Carotene - therapeutic use ; Cardiovascular diseases ; Carotid Intima-Media Thickness ; climacteric syndrome ; Double-Blind Method ; Emotions ; Female ; Garlic ; Green tea ; Herbal medicine ; Hormone replacement therapy ; Humans ; Low density lipoprotein ; Menopause ; Middle Aged ; perimenopause ; Perimenopause - drug effects ; Phytoestrogens ; Phytoestrogens - therapeutic use ; phytoestrogen‐rich natural preparation ; Phytotherapy ; Prevention ; Quality of Life ; Seeds ; Statistical analysis ; Tea</subject><ispartof>Phytotherapy research, 2017-08, Vol.31 (8), p.1209-1214</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3161-a1e77f1827eea8536f24238e7cb639a85d1adbdeea4e813d332362282c212cbb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5841$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5841$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28593720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirichenko, T. V.</creatorcontrib><creatorcontrib>Myasoedova, V. A.</creatorcontrib><creatorcontrib>Orekhova, V. A.</creatorcontrib><creatorcontrib>Ravani, A. L.</creatorcontrib><creatorcontrib>Nikitina, N. A.</creatorcontrib><creatorcontrib>Grechko, A. V.</creatorcontrib><creatorcontrib>Sobenin, I. A.</creatorcontrib><creatorcontrib>Orekhov, A. N.</creatorcontrib><title>Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima‐media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow‐up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima‐media thickness between the two groups was not statistically significant at follow‐up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. Copyright © 2017 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>alpha-Tocopherol - therapeutic use</subject><subject>Arteriosclerosis</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - prevention & control</subject><subject>beta Carotene - therapeutic use</subject><subject>Cardiovascular diseases</subject><subject>Carotid Intima-Media Thickness</subject><subject>climacteric syndrome</subject><subject>Double-Blind Method</subject><subject>Emotions</subject><subject>Female</subject><subject>Garlic</subject><subject>Green tea</subject><subject>Herbal medicine</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Low density lipoprotein</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>perimenopause</subject><subject>Perimenopause - drug effects</subject><subject>Phytoestrogens</subject><subject>Phytoestrogens - therapeutic use</subject><subject>phytoestrogen‐rich natural preparation</subject><subject>Phytotherapy</subject><subject>Prevention</subject><subject>Quality of Life</subject><subject>Seeds</subject><subject>Statistical analysis</subject><subject>Tea</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9O3DAQxq2qVVlopT4BstRLL6EeO86fI1pRQEKwgq3aW-Q4EzYosYPtgPbGhXufkSfBEdADF4_k-X3fePwR8g3YATDGf47BHcgihQ9kAawsE5C5-EgWrJSQpFD83SG73t8wxkrO0s9khxeyFDlnC_K42myDRR-cvUbz9PDvstMbeq7C5FRPVw5H5VTorKGtdXTtUIUBTaC2pcu-G5QO6DpNr7amcXZAqkxDD8MGnfW6n8_Ozy53UTObdIauoiBa2FFNPo74E1XmC_nUqt7j19e6R37_OlovT5Kzi-PT5eFZogVkkCjAPG-h4DmiKqTIWp5yUWCu60yU8aYB1dRNbKZYgGiE4CLjvOCaA9d1LfbIjxff0dnbKW5dDZ3X2PfKoJ18BSXLBecMZES_v0Nv7ORMfF2kuJSQZ3Km9l-pqR6wqca4m3Lb6u2DI5C8APddj9v_fWDVHFwVg6vm4KrV-nKu4hkT6421</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Kirichenko, T. V.</creator><creator>Myasoedova, V. A.</creator><creator>Orekhova, V. A.</creator><creator>Ravani, A. L.</creator><creator>Nikitina, N. A.</creator><creator>Grechko, A. V.</creator><creator>Sobenin, I. A.</creator><creator>Orekhov, A. N.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women</title><author>Kirichenko, T. V. ; Myasoedova, V. A. ; Orekhova, V. A. ; Ravani, A. L. ; Nikitina, N. A. ; Grechko, A. V. ; Sobenin, I. A. ; Orekhov, A. 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V.</au><au>Myasoedova, V. A.</au><au>Orekhova, V. A.</au><au>Ravani, A. L.</au><au>Nikitina, N. A.</au><au>Grechko, A. V.</au><au>Sobenin, I. A.</au><au>Orekhov, A. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2017-08</date><risdate>2017</risdate><volume>31</volume><issue>8</issue><spage>1209</spage><epage>1214</epage><pages>1209-1214</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen‐rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima‐media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow‐up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima‐media thickness between the two groups was not statistically significant at follow‐up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. Copyright © 2017 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28593720</pmid><doi>10.1002/ptr.5841</doi><tpages>6</tpages></addata></record> |
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subjects | Adult alpha-Tocopherol - therapeutic use Arteriosclerosis Ascorbic Acid - therapeutic use Atherosclerosis Atherosclerosis - prevention & control beta Carotene - therapeutic use Cardiovascular diseases Carotid Intima-Media Thickness climacteric syndrome Double-Blind Method Emotions Female Garlic Green tea Herbal medicine Hormone replacement therapy Humans Low density lipoprotein Menopause Middle Aged perimenopause Perimenopause - drug effects Phytoestrogens Phytoestrogens - therapeutic use phytoestrogen‐rich natural preparation Phytotherapy Prevention Quality of Life Seeds Statistical analysis Tea |
title | Phytoestrogen‐Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women |
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