Thiosemicarbazones as inhibitors of tyrosinase enzyme

[Display omitted] In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. The results showed that all the thiosemicarbazones tested exhibited significant inhibitory effects on th...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2017-08, Vol.27 (15), p.3546-3550
Hauptverfasser:	Soares, Mariana A., Almeida, Mariana A., Marins-Goulart, Carla, Chaves, Otávio A., Echevarria, Aurea, de Oliveira, Márcia C.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - drug effects Agaricales - enzymology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Levodopa - metabolism Melanin Melanins - metabolism Melanoma - drug therapy Melanoma - enzymology Melanome Molecular docking Molecular Docking Simulation Monophenol Monooxygenase - antagonists & inhibitors Monophenol Monooxygenase - metabolism Phenol oxidase Thiosemicarbazones Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology
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