The tobacco cembranoid (1S,2E,4S,7E,11E)-2,7,11-cembratriene-4,6-diol as a novel angiogenesis inhibitory lead for the control of breast malignancies

[Display omitted] (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol (1) and its 4-epi-analog (2) are diterpene precursors of the key flavor components in most Nicotiana (tobacco) species that purposely degraded during commercial tobacco fermentation. Angiogenesis, recruitment of new blood vessels, i...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2017-08, Vol.25 (15), p.3911-3921
Hauptverfasser:	Hailat, Mohammad M., Ebrahim, Hassan Y., Mohyeldin, Mohamed M., Goda, Amira A., Siddique, Abu Bakar, El Sayed, Khalid A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Breast cancer Cell Line, Tumor Diterpenes - pharmacology FAK Female Humans Mice Nicotiana - chemistry Paxillin Tobacco cembranoids VEGFR2 Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
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