Predictive model for the development of hypertensive cardiopathy: A prospective cohort study
Predictive models of cardiovascular conditions are useful tools for risk stratification. The high morbidity and mortality resulting from hypertensive cardiopathy creates a need for the use of tools to predict the risk of cardiovascular disease. To evaluate the capacity of a model based on risk facto...
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| Veröffentlicht in: | Medwave 2017-05, Vol.17 (4), p.e6954-e6954 |
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| creator | Álvarez Aliaga, Alexis González-Aguilera, Julio César Maceo-Gómez, Liliana Del Rosario Suárez-Quesada, Alexis |
| description | Predictive models of cardiovascular conditions are useful tools for risk stratification. The high morbidity and mortality resulting from hypertensive cardiopathy creates a need for the use of tools to predict the risk of cardiovascular disease.
To evaluate the capacity of a model based on risk factors to predict the development of hypertensive cardiopathy after ten years in patients with a diagnosis of essential arterial hypertension.
A prospective cohort study was carried out in hypertensive patients cared for at the specialized arterial hypertension physicians office of the Specialty Policlinic attached to Carlos Manuel de Céspedes Hospital, Bayamo Municipality, Granma Province, Cuba, from January 1, 2000 to December 31, 2009. A predictive model was constructed and validated through a process that included the random split of the whole sample in two parts: one for development (parameters estimation) and the other for validation.
The binary regression model adjusted by the step-by-step backward method, showed that in step six, 13 variables sufficed to estimate the risk of developing hypertensive cardiopathy. In the estimation sample, the area under the receiver operating characteristic curve obtained for the prediction of hypertensive heart disease was 0.985 (confidence interval: 0.980-0.990; p = |
| doi_str_mv | 10.5867/medwave.2017.04.6954 |
| format | Article |
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To evaluate the capacity of a model based on risk factors to predict the development of hypertensive cardiopathy after ten years in patients with a diagnosis of essential arterial hypertension.
A prospective cohort study was carried out in hypertensive patients cared for at the specialized arterial hypertension physicians office of the Specialty Policlinic attached to Carlos Manuel de Céspedes Hospital, Bayamo Municipality, Granma Province, Cuba, from January 1, 2000 to December 31, 2009. A predictive model was constructed and validated through a process that included the random split of the whole sample in two parts: one for development (parameters estimation) and the other for validation.
The binary regression model adjusted by the step-by-step backward method, showed that in step six, 13 variables sufficed to estimate the risk of developing hypertensive cardiopathy. In the estimation sample, the area under the receiver operating characteristic curve obtained for the prediction of hypertensive heart disease was 0.985 (confidence interval: 0.980-0.990; p = <0.0005). In the validation sample the area under the receiver operating characteristic curve was 0.963 (confidence interval: 0.953-0, 0.973, p<0.0005). The calibration of the model was also adequate (p = 0.863).
The model obtained proved is a clinical and epidemiological surveillance instrument, useful to identify subjects with greater likelihood to acquire hypertensive heart disease, and to stratify their risk in the following ten-year period.</description><identifier>ISSN: 0717-6384</identifier><identifier>EISSN: 0717-6384</identifier><identifier>DOI: 10.5867/medwave.2017.04.6954</identifier><identifier>PMID: 28582382</identifier><language>eng ; spa</language><publisher>Chile</publisher><subject>Aged ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cohort Studies ; Cuba - epidemiology ; Female ; Humans ; Hypertension - complications ; Male ; Middle Aged ; Models, Statistical ; Prospective Studies ; Risk Factors ; Time Factors</subject><ispartof>Medwave, 2017-05, Vol.17 (4), p.e6954-e6954</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-b1202c111c695bd86ccc067c8fdce0bafbf3c18999d75dd4df028de874d63e833</citedby><cites>FETCH-LOGICAL-c307t-b1202c111c695bd86ccc067c8fdce0bafbf3c18999d75dd4df028de874d63e833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28582382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Álvarez Aliaga, Alexis</creatorcontrib><creatorcontrib>González-Aguilera, Julio César</creatorcontrib><creatorcontrib>Maceo-Gómez, Liliana Del Rosario</creatorcontrib><creatorcontrib>Suárez-Quesada, Alexis</creatorcontrib><title>Predictive model for the development of hypertensive cardiopathy: A prospective cohort study</title><title>Medwave</title><addtitle>Medwave</addtitle><description>Predictive models of cardiovascular conditions are useful tools for risk stratification. The high morbidity and mortality resulting from hypertensive cardiopathy creates a need for the use of tools to predict the risk of cardiovascular disease.
To evaluate the capacity of a model based on risk factors to predict the development of hypertensive cardiopathy after ten years in patients with a diagnosis of essential arterial hypertension.
A prospective cohort study was carried out in hypertensive patients cared for at the specialized arterial hypertension physicians office of the Specialty Policlinic attached to Carlos Manuel de Céspedes Hospital, Bayamo Municipality, Granma Province, Cuba, from January 1, 2000 to December 31, 2009. A predictive model was constructed and validated through a process that included the random split of the whole sample in two parts: one for development (parameters estimation) and the other for validation.
The binary regression model adjusted by the step-by-step backward method, showed that in step six, 13 variables sufficed to estimate the risk of developing hypertensive cardiopathy. In the estimation sample, the area under the receiver operating characteristic curve obtained for the prediction of hypertensive heart disease was 0.985 (confidence interval: 0.980-0.990; p = <0.0005). In the validation sample the area under the receiver operating characteristic curve was 0.963 (confidence interval: 0.953-0, 0.973, p<0.0005). The calibration of the model was also adequate (p = 0.863).
The model obtained proved is a clinical and epidemiological surveillance instrument, useful to identify subjects with greater likelihood to acquire hypertensive heart disease, and to stratify their risk in the following ten-year period.</description><subject>Aged</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cohort Studies</subject><subject>Cuba - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0717-6384</issn><issn>0717-6384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE9LxDAQxYMorqz7DURy9NKatGmSelsW_8GCHvQmhDaZ0kq7qUm60m9vy67iXGYO7828-SF0RUmcSS5uOzDfxR7ihFARExbzPGMn6IIIKiKeSnb6b16glfefZCpJZcbZOVokMpNJKpML9PHqwDQ6NHvAnTXQ4so6HGrABvbQ2r6DXcC2wvXYgwuw87NSF840ti9CPd7hNe6d9T0clmhbWxewD4MZL9FZVbQeVse-RO8P92-bp2j78vi8WW8jnRIRopImJNGUUj29URrJtdaECy0ro4GURVVWqaYyz3MjMmOYqUgiDUjBDE9BpukS3Rz2TkG-BvBBdY3X0LbFDuzgFc0JZ1yyLJ-k7CDVU2bvoFK9a7rCjYoSNaNVR7RqRqsIUzPayXZ9vDCUk-DP9Asy_QF62Hjp</recordid><startdate>20170509</startdate><enddate>20170509</enddate><creator>Álvarez Aliaga, Alexis</creator><creator>González-Aguilera, Julio César</creator><creator>Maceo-Gómez, Liliana Del Rosario</creator><creator>Suárez-Quesada, Alexis</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170509</creationdate><title>Predictive model for the development of hypertensive cardiopathy: A prospective cohort study</title><author>Álvarez Aliaga, Alexis ; González-Aguilera, Julio César ; Maceo-Gómez, Liliana Del Rosario ; Suárez-Quesada, Alexis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-b1202c111c695bd86ccc067c8fdce0bafbf3c18999d75dd4df028de874d63e833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cohort Studies</topic><topic>Cuba - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Álvarez Aliaga, Alexis</creatorcontrib><creatorcontrib>González-Aguilera, Julio César</creatorcontrib><creatorcontrib>Maceo-Gómez, Liliana Del Rosario</creatorcontrib><creatorcontrib>Suárez-Quesada, Alexis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medwave</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Álvarez Aliaga, Alexis</au><au>González-Aguilera, Julio César</au><au>Maceo-Gómez, Liliana Del Rosario</au><au>Suárez-Quesada, Alexis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive model for the development of hypertensive cardiopathy: A prospective cohort study</atitle><jtitle>Medwave</jtitle><addtitle>Medwave</addtitle><date>2017-05-09</date><risdate>2017</risdate><volume>17</volume><issue>4</issue><spage>e6954</spage><epage>e6954</epage><pages>e6954-e6954</pages><issn>0717-6384</issn><eissn>0717-6384</eissn><abstract>Predictive models of cardiovascular conditions are useful tools for risk stratification. The high morbidity and mortality resulting from hypertensive cardiopathy creates a need for the use of tools to predict the risk of cardiovascular disease.
To evaluate the capacity of a model based on risk factors to predict the development of hypertensive cardiopathy after ten years in patients with a diagnosis of essential arterial hypertension.
A prospective cohort study was carried out in hypertensive patients cared for at the specialized arterial hypertension physicians office of the Specialty Policlinic attached to Carlos Manuel de Céspedes Hospital, Bayamo Municipality, Granma Province, Cuba, from January 1, 2000 to December 31, 2009. A predictive model was constructed and validated through a process that included the random split of the whole sample in two parts: one for development (parameters estimation) and the other for validation.
The binary regression model adjusted by the step-by-step backward method, showed that in step six, 13 variables sufficed to estimate the risk of developing hypertensive cardiopathy. In the estimation sample, the area under the receiver operating characteristic curve obtained for the prediction of hypertensive heart disease was 0.985 (confidence interval: 0.980-0.990; p = <0.0005). In the validation sample the area under the receiver operating characteristic curve was 0.963 (confidence interval: 0.953-0, 0.973, p<0.0005). The calibration of the model was also adequate (p = 0.863).
The model obtained proved is a clinical and epidemiological surveillance instrument, useful to identify subjects with greater likelihood to acquire hypertensive heart disease, and to stratify their risk in the following ten-year period.</abstract><cop>Chile</cop><pmid>28582382</pmid><doi>10.5867/medwave.2017.04.6954</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cohort Studies Cuba - epidemiology Female Humans Hypertension - complications Male Middle Aged Models, Statistical Prospective Studies Risk Factors Time Factors |
| title | Predictive model for the development of hypertensive cardiopathy: A prospective cohort study |
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