Prevalence and influence on outcome of HER2/neu, HER3 and NRG1 expression in patients with metastatic colorectal cancer

Our aim was to explore the impact of the HER2/neu, HER3 receptor as well as their ligands’ neuregulin (NRG1) expression on the outcome of patients with metastatic colorectal cancer (mCRC). NRG1, HER2/neu and HER3 expression was evaluated in 208 patients with mCRC receiving 5-FU/LV plus irinotecan or...

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Veröffentlicht in:	Anti-cancer drugs 2017-08, Vol.28 (7), p.717-722
Hauptverfasser:	Stahler, Arndt, Heinemann, Volker, Neumann, Jens, Crispin, Alexander, Schalhorn, Andreas, Stintzing, Sebastian, Giessen-Jung, Clemens, Fischer von Weikersthal, Ludwig, Vehling-Kaiser, Ursula, Stauch, Martina, Quietzsch, Detlef, Holch, Julian W, Kruger, Stephan, Haas, Michael, Michl, Marlies, von Einem, Jobst, Kirchner, Thomas, Jung, Andreas, Modest, Dominik P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - biosynthesis Camptothecin - administration & dosage Camptothecin - analogs & derivatives Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Fluorouracil - administration & dosage Humans Leucovorin - administration & dosage Neoplasm Metastasis Neuregulin-1 - biosynthesis Neuregulin-1 - genetics Organoplatinum Compounds - administration & dosage Prognosis Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Receptor, ErbB-3 - biosynthesis Receptor, ErbB-3 - genetics Retrospective Studies
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