MicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/β-catenin signaling pathway

Epithelial-mesenchymal transition (EMT) plays a critical role in the process of cancer invasion and metastasis. The Wnt/β-catenin signaling pathway is known as a stimulative factor, which may trigger EMT and metastasis of cancer cells. In addition, several microRNAs (miRNAs) have been proven to regu...

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Veröffentlicht in:	Oncology reports 2017-07, Vol.38 (1), p.301-308
Hauptverfasser:	Peng, Long, Liu, Zhanying, Xiao, Jian, Tu, Yi, Wan, Zhen, Xiong, Haiwei, Li, Yong, Xiao, Weidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis beta Catenin - antagonists & inhibitors beta Catenin - genetics beta Catenin - metabolism Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Genes Humans Male Medical prognosis Metastasis MicroRNAs - genetics Middle Aged Neoplasm Invasiveness Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Prognosis Proteins Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Signal Transduction Tumor Cells, Cultured Tumors Wnt Proteins - antagonists & inhibitors Wnt Proteins - genetics Wnt Proteins - metabolism
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