Determination of Vedaprofen in Livestock Products and Seafoods by Liquid Chromatography-Tandem Mass Spectrometry
A novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the trace residue determination of vedaprofen (VPF) in livestock products and seafoods. VPF was extracted from each sample with acidified acetone, and the crude extract was re-extracted with ethyl acetate and...
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| Veröffentlicht in: | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 2011/10/25, Vol.52(5), pp.304-308 |
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| container_title | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) |
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| creator | ISHIHARA, Michiyo FUJITA, Kazuhiro ITO, Hironobu MATSUDA, Takahiro YATSUKAWA, Yoh-ichi NAKAMURA, Munetomo SAKAI, Takatoshi NEMOTO, Satoru |
| description | A novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the trace residue determination of vedaprofen (VPF) in livestock products and seafoods. VPF was extracted from each sample with acidified acetone, and the crude extract was re-extracted with ethyl acetate and NaCl solution. Clean-up was performed using a weak anion exchange cartridge (Bond Elut DEA). The LC separation was performed on a C18 column using acetonitrile-0.0025 mol/L formic acid (3 : 2) as the mobile phase and MS was run in the negative ion electrospray ionization mode. The calibration curve was linear in the range of 0.001-0.1 μg/mL VPF. The mean recoveries from equine muscle, cattle muscle, cattle liver, cattle fat, salmon, eel, corbicula, milk, egg and buckwheat honey were 72-94%, and the relative standard deviations (RSDs) were 1.1-2.0%. Limits of quantitation (LOQs) ranged from 0.001 to 0.007 μg/g. |
| doi_str_mv | 10.3358/shokueishi.52.304 |
| format | Article |
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VPF was extracted from each sample with acidified acetone, and the crude extract was re-extracted with ethyl acetate and NaCl solution. Clean-up was performed using a weak anion exchange cartridge (Bond Elut DEA). The LC separation was performed on a C18 column using acetonitrile-0.0025 mol/L formic acid (3 : 2) as the mobile phase and MS was run in the negative ion electrospray ionization mode. The calibration curve was linear in the range of 0.001-0.1 μg/mL VPF. The mean recoveries from equine muscle, cattle muscle, cattle liver, cattle fat, salmon, eel, corbicula, milk, egg and buckwheat honey were 72-94%, and the relative standard deviations (RSDs) were 1.1-2.0%. Limits of quantitation (LOQs) ranged from 0.001 to 0.007 μg/g.</description><identifier>ISSN: 0015-6426</identifier><identifier>EISSN: 1882-1006</identifier><identifier>DOI: 10.3358/shokueishi.52.304</identifier><identifier>PMID: 22200750</identifier><language>jpn</language><publisher>Japan: Japanese Society for Food Hygiene and Safety</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - analysis ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Chromatography, Liquid - methods ; Drug Residues - analysis ; Drug Residues - isolation & purification ; Eggs - analysis ; Food Analysis - methods ; Honey - analysis ; LC-MS/MS ; Livestock ; livestock product ; Meat Products - analysis ; Milk - chemistry ; Naphthalenes - analysis ; Naphthalenes - isolation & purification ; Propionates - analysis ; Propionates - isolation & purification ; seafood ; Seafood - analysis ; Tandem Mass Spectrometry - methods ; vedaprofen</subject><ispartof>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 2011/10/25, Vol.52(5), pp.304-308</ispartof><rights>2011 Japanese Society for Food Hygiene and Safety</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22200750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISHIHARA, Michiyo</creatorcontrib><creatorcontrib>FUJITA, Kazuhiro</creatorcontrib><creatorcontrib>ITO, Hironobu</creatorcontrib><creatorcontrib>MATSUDA, Takahiro</creatorcontrib><creatorcontrib>YATSUKAWA, Yoh-ichi</creatorcontrib><creatorcontrib>NAKAMURA, Munetomo</creatorcontrib><creatorcontrib>SAKAI, Takatoshi</creatorcontrib><creatorcontrib>NEMOTO, Satoru</creatorcontrib><title>Determination of Vedaprofen in Livestock Products and Seafoods by Liquid Chromatography-Tandem Mass Spectrometry</title><title>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</title><addtitle>Food Hyg. Saf. Sci.</addtitle><description>A novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the trace residue determination of vedaprofen (VPF) in livestock products and seafoods. VPF was extracted from each sample with acidified acetone, and the crude extract was re-extracted with ethyl acetate and NaCl solution. Clean-up was performed using a weak anion exchange cartridge (Bond Elut DEA). The LC separation was performed on a C18 column using acetonitrile-0.0025 mol/L formic acid (3 : 2) as the mobile phase and MS was run in the negative ion electrospray ionization mode. The calibration curve was linear in the range of 0.001-0.1 μg/mL VPF. The mean recoveries from equine muscle, cattle muscle, cattle liver, cattle fat, salmon, eel, corbicula, milk, egg and buckwheat honey were 72-94%, and the relative standard deviations (RSDs) were 1.1-2.0%. Limits of quantitation (LOQs) ranged from 0.001 to 0.007 μg/g.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - analysis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</subject><subject>Chromatography, Liquid - methods</subject><subject>Drug Residues - analysis</subject><subject>Drug Residues - isolation & purification</subject><subject>Eggs - analysis</subject><subject>Food Analysis - methods</subject><subject>Honey - analysis</subject><subject>LC-MS/MS</subject><subject>Livestock</subject><subject>livestock product</subject><subject>Meat Products - analysis</subject><subject>Milk - chemistry</subject><subject>Naphthalenes - analysis</subject><subject>Naphthalenes - isolation & purification</subject><subject>Propionates - analysis</subject><subject>Propionates - isolation & purification</subject><subject>seafood</subject><subject>Seafood - analysis</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>vedaprofen</subject><issn>0015-6426</issn><issn>1882-1006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0UtLxDAQAOAgii7qD_AiOXrpmkeTtkdZn7CisKvXkiZTG902NUmF_fcG1sdl5jAfwzwQOqNkzrkoL0PnPiawobNzweac5HtoRsuSZZQQuY9mhFCRyZzJI3Qagm0II3nBikoeoiPGGCGFIDM0XkME39tBResG7Fr8CkaN3rUwYDvgpf2CEJ3-wM_emUnHgNVg8ApU65wJuNkm8jlZgxedd72K7s2rsdtm68Sgx48qBLwaQcdUhei3J-igVZsApz_5GL3c3qwX99ny6e5hcbXM3tOcMatoQ0FBVUhetVQIwSudN1I0tKBUGlPqQhctbaAqC8JMQ7mmuhQ5hVZxbYAfo4td37TL55R2qHsbNGw2agA3hZpWROaS5ixP9PyHTk0Pph697ZXf1r9XSuB2B95DVG_wB5SPVm-g_n9FLVgtdiF95A_oTvkaBv4NPd2IIQ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>ISHIHARA, Michiyo</creator><creator>FUJITA, Kazuhiro</creator><creator>ITO, Hironobu</creator><creator>MATSUDA, Takahiro</creator><creator>YATSUKAWA, Yoh-ichi</creator><creator>NAKAMURA, Munetomo</creator><creator>SAKAI, Takatoshi</creator><creator>NEMOTO, Satoru</creator><general>Japanese Society for Food Hygiene and Safety</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>2011</creationdate><title>Determination of Vedaprofen in Livestock Products and Seafoods by Liquid Chromatography-Tandem Mass Spectrometry</title><author>ISHIHARA, Michiyo ; FUJITA, Kazuhiro ; ITO, Hironobu ; MATSUDA, Takahiro ; YATSUKAWA, Yoh-ichi ; NAKAMURA, Munetomo ; SAKAI, Takatoshi ; NEMOTO, Satoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j204t-91b1eae97639f155539c4b65b17116dd8c7c7f1be98702db13c1c8541efa3cde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - analysis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Chromatography, Liquid - methods</topic><topic>Drug Residues - analysis</topic><topic>Drug Residues - isolation & purification</topic><topic>Eggs - analysis</topic><topic>Food Analysis - methods</topic><topic>Honey - analysis</topic><topic>LC-MS/MS</topic><topic>Livestock</topic><topic>livestock product</topic><topic>Meat Products - analysis</topic><topic>Milk - chemistry</topic><topic>Naphthalenes - analysis</topic><topic>Naphthalenes - isolation & purification</topic><topic>Propionates - analysis</topic><topic>Propionates - isolation & purification</topic><topic>seafood</topic><topic>Seafood - analysis</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>vedaprofen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISHIHARA, Michiyo</creatorcontrib><creatorcontrib>FUJITA, Kazuhiro</creatorcontrib><creatorcontrib>ITO, Hironobu</creatorcontrib><creatorcontrib>MATSUDA, Takahiro</creatorcontrib><creatorcontrib>YATSUKAWA, Yoh-ichi</creatorcontrib><creatorcontrib>NAKAMURA, Munetomo</creatorcontrib><creatorcontrib>SAKAI, Takatoshi</creatorcontrib><creatorcontrib>NEMOTO, Satoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISHIHARA, Michiyo</au><au>FUJITA, Kazuhiro</au><au>ITO, Hironobu</au><au>MATSUDA, Takahiro</au><au>YATSUKAWA, Yoh-ichi</au><au>NAKAMURA, Munetomo</au><au>SAKAI, Takatoshi</au><au>NEMOTO, Satoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Vedaprofen in Livestock Products and Seafoods by Liquid Chromatography-Tandem Mass Spectrometry</atitle><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle><addtitle>Food Hyg. 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The mean recoveries from equine muscle, cattle muscle, cattle liver, cattle fat, salmon, eel, corbicula, milk, egg and buckwheat honey were 72-94%, and the relative standard deviations (RSDs) were 1.1-2.0%. Limits of quantitation (LOQs) ranged from 0.001 to 0.007 μg/g.</abstract><cop>Japan</cop><pub>Japanese Society for Food Hygiene and Safety</pub><pmid>22200750</pmid><doi>10.3358/shokueishi.52.304</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 2011/10/25, Vol.52(5), pp.304-308 |
| issn | 0015-6426 1882-1006 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; AgriKnowledge（アグリナレッジ）AGROLib |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - analysis Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Chromatography, Liquid - methods Drug Residues - analysis Drug Residues - isolation & purification Eggs - analysis Food Analysis - methods Honey - analysis LC-MS/MS Livestock livestock product Meat Products - analysis Milk - chemistry Naphthalenes - analysis Naphthalenes - isolation & purification Propionates - analysis Propionates - isolation & purification seafood Seafood - analysis Tandem Mass Spectrometry - methods vedaprofen |
| title | Determination of Vedaprofen in Livestock Products and Seafoods by Liquid Chromatography-Tandem Mass Spectrometry |
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