A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction

RATIONALE:Familial sinus node and atrioventricular conduction dysfunction is a rare disorder that leads to paroxysmal dizziness, fatigue, and syncope because of a temporarily or permanently reduced heart rate. To date, only a few genes for familial sinus and atrioventricular conduction dysfunction a...

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Veröffentlicht in:	Circulation research 2017-05, Vol.120 (10), p.e33-e44
Hauptverfasser:	Stallmeyer, Birgit, Kuß, Johanna, Kotthoff, Stefan, Zumhagen, Sven, Vowinkel, Kirsty, Rinné, Susanne, Matschke, Lina A, Friedrich, Corinna, Schulze-Bahr, Ellen, Rust, Stephan, Seebohm, Guiscard, Decher, Niels, Schulze-Bahr, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Atrioventricular Block - diagnosis Atrioventricular Block - genetics Atrioventricular Block - physiopathology Calcium channels (voltage-gated) Cardiac arrhythmia Chromosome 7 Conduction Fatigue Female Gene Expression Profiling - methods Genome-Wide Association Study - methods Genomes GTP-Binding Proteins - genetics Heart Conduction System - physiopathology Heart diseases Heart rate HEK293 Cells Humans Ion channels Ion channels (cyclic nucleotide-gated) Linkage analysis Male Membrane potential Middle Aged Mutation Mutation - genetics Oocytes Phenotypes Point mutation Potassium channels Potassium channels (inwardly-rectifying) Proteins Sick Sinus Syndrome - diagnosis Sick Sinus Syndrome - genetics Sick Sinus Syndrome - physiopathology Sinoatrial Node - physiology Sinus Sinuses Syncope Vagus nerve Xenopus laevis Young Adult
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