Leptospira spp. in Small Mammals from Areas with Low and High Human Hantavirus Incidences in South-West Germany
Introduction: Leptospirosis is caused by Leptospira spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for Leptospira spp. and PUUV. Seewis virus (SWSV)...
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| Veröffentlicht in: | Vector borne and zoonotic diseases (Larchmont, N.Y.) N.Y.), 2017-05, Vol.17 (5), p.312-318 |
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| creator | Obiegala, Anna Albrecht, Christoph Dafalla, Maysaa Drewes, Stephan Oltersdorf, Carolin Turni, Hendrik Imholt, Christian Jacob, Jens Wagner-Wiening, Christiane Ulrich, Rainer G. Pfeffer, Martin |
| description | Introduction:
Leptospirosis is caused by
Leptospira
spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for
Leptospira
spp. and PUUV. Seewis virus (SWSV) is a shrew-borne hantavirus with unknown pathogenicity. The objective of this study was to estimate the prevalence for
Leptospira
spp. and the frequency of
Leptospira
-hantavirus co-infections in small mammals collected at locations with high and low incidences in humans.
Materials and Methods:
In 2012 and 2013, 736 small mammals belonging to seven species (
Apodemus flavicollis
,
Microtus agrestis
,
Microtus arvalis
,
Myodes glareolus
,
Sorex araneus
,
S. coronatus
, and
S. minutus
) were collected at four high incidence sites (H1-H4) and four low (L1-L4) incidence sites for PUUV infection in humans. Kidney-derived DNA samples were tested for
Leptospira
spp. by real-time PCR targeting the
lipl 32
gene and further analyzed by duplex PCR targeting the
flaB
and the
secY
genes. For the detection of Seewis virus, lung-derived DNA was tested via RT-PCR targeting the nucleocapsid gene.
Results:
Altogether, 42 of the 736 small mammals including 27 of 660 bank voles and 11 of 66 shrews, were positive for
Leptospira
spp., while
Sorex
spp. (14.7%) showed significantly higher prevalences compared to bank voles (4.1%). Detected
Leptospira
spp. were pathogenic species other than
L. kirschneri
. Significantly more
Leptospira
-positive bank voles were found at H sites than at L sites. Altogether 22.2% of positive bank voles were infected with PUUV. Double infection of PUUV and
Leptospira
spp. occurrence in bank voles is 1.86 times (OR = 1.86; 95% CI: 0.72–4.73) more likely than infections with each pathogen separately.
Discussion:
Leptospira
- positive bank voles are focally positively associated with PUUV infection in bank voles and with human hantavirus cases. It should be considered that shrews may serve as
Leptospira
spp. reservoirs. |
| doi_str_mv | 10.1089/vbz.2016.2036 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1906458801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1906458801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-a56e40e51e398c6b7a0a315c86271f05330b17aca2368a2709761fc41d0de44f3</originalsourceid><addsrcrecordid>eNqFkTtP3TAYQK2qqDzakbWy1IUlF392_MiIUMtFuogBEGPkOA7XKLFTOwHBr8fppR26sPizraMjWwehYyArIKo6fWpeV5SAyAsTn9ABcC4LKXn1edkzUjAh5D46TOmREAoK-Be0TxVjtKLyAIWNHaeQRhc1TuO4ws7jm0H3Pb7SQ54JdzEM-CxanfCzm7Z4E56x9i1eu4ctXs-D9nit_aSfXJwTvvTGtdYbm_6Ywjxti3ubJnxhY0ZfvqK9Llvtt_d5hO5-_bw9Xxeb64vL87NNYVilpkJzYUtiOdh8NKKRmmgG3ChBJXSEM0YakNpoyoTSVJJKCuhMCS1pbVl27Aid7LxjDL_n_IB6cMnYvtfehjnVUBFRcqUIfIxmqpTASJXRH_-hj2GOPn8kCykDVlKlMlXsKBNDStF29RjdoONLDaReotU5Wr1Eq5domf_-bp2bwbb_6L-VMsB2wHKtve-dbWycPtC-ARODobw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1923134288</pqid></control><display><type>article</type><title>Leptospira spp. in Small Mammals from Areas with Low and High Human Hantavirus Incidences in South-West Germany</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Obiegala, Anna ; Albrecht, Christoph ; Dafalla, Maysaa ; Drewes, Stephan ; Oltersdorf, Carolin ; Turni, Hendrik ; Imholt, Christian ; Jacob, Jens ; Wagner-Wiening, Christiane ; Ulrich, Rainer G. ; Pfeffer, Martin</creator><creatorcontrib>Obiegala, Anna ; Albrecht, Christoph ; Dafalla, Maysaa ; Drewes, Stephan ; Oltersdorf, Carolin ; Turni, Hendrik ; Imholt, Christian ; Jacob, Jens ; Wagner-Wiening, Christiane ; Ulrich, Rainer G. ; Pfeffer, Martin</creatorcontrib><description>Introduction:
Leptospirosis is caused by
Leptospira
spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for
Leptospira
spp. and PUUV. Seewis virus (SWSV) is a shrew-borne hantavirus with unknown pathogenicity. The objective of this study was to estimate the prevalence for
Leptospira
spp. and the frequency of
Leptospira
-hantavirus co-infections in small mammals collected at locations with high and low incidences in humans.
Materials and Methods:
In 2012 and 2013, 736 small mammals belonging to seven species (
Apodemus flavicollis
,
Microtus agrestis
,
Microtus arvalis
,
Myodes glareolus
,
Sorex araneus
,
S. coronatus
, and
S. minutus
) were collected at four high incidence sites (H1-H4) and four low (L1-L4) incidence sites for PUUV infection in humans. Kidney-derived DNA samples were tested for
Leptospira
spp. by real-time PCR targeting the
lipl 32
gene and further analyzed by duplex PCR targeting the
flaB
and the
secY
genes. For the detection of Seewis virus, lung-derived DNA was tested via RT-PCR targeting the nucleocapsid gene.
Results:
Altogether, 42 of the 736 small mammals including 27 of 660 bank voles and 11 of 66 shrews, were positive for
Leptospira
spp., while
Sorex
spp. (14.7%) showed significantly higher prevalences compared to bank voles (4.1%). Detected
Leptospira
spp. were pathogenic species other than
L. kirschneri
. Significantly more
Leptospira
-positive bank voles were found at H sites than at L sites. Altogether 22.2% of positive bank voles were infected with PUUV. Double infection of PUUV and
Leptospira
spp. occurrence in bank voles is 1.86 times (OR = 1.86; 95% CI: 0.72–4.73) more likely than infections with each pathogen separately.
Discussion:
Leptospira
- positive bank voles are focally positively associated with PUUV infection in bank voles and with human hantavirus cases. It should be considered that shrews may serve as
Leptospira
spp. reservoirs.</description><identifier>ISSN: 1530-3667</identifier><identifier>EISSN: 1557-7759</identifier><identifier>DOI: 10.1089/vbz.2016.2036</identifier><identifier>PMID: 28332927</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Apodemus flavicollis ; Arvicolinae - microbiology ; Deoxyribonucleic acid ; DNA ; Epidemics ; Germany - epidemiology ; Hantavirus ; Hantavirus Infections - epidemiology ; Humans ; Incidence ; Infections ; Kidneys ; Leptospira ; Leptospira - classification ; Leptospira - isolation & purification ; Leptospirosis ; Leptospirosis - epidemiology ; Leptospirosis - veterinary ; Lungs ; Mammals ; Microtus agrestis ; Microtus arvalis ; Murinae - microbiology ; Myodes ; Nucleocapsids ; Original Articles ; Pathogenicity ; Pathogens ; Polymerase chain reaction ; Real time ; Shrews - microbiology ; Small mammals ; Sorex ; Sorex araneus ; Viruses ; Zoonoses</subject><ispartof>Vector borne and zoonotic diseases (Larchmont, N.Y.), 2017-05, Vol.17 (5), p.312-318</ispartof><rights>2017, Mary Ann Liebert, Inc.</rights><rights>(©) Copyright 2017, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-a56e40e51e398c6b7a0a315c86271f05330b17aca2368a2709761fc41d0de44f3</citedby><cites>FETCH-LOGICAL-c398t-a56e40e51e398c6b7a0a315c86271f05330b17aca2368a2709761fc41d0de44f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28332927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obiegala, Anna</creatorcontrib><creatorcontrib>Albrecht, Christoph</creatorcontrib><creatorcontrib>Dafalla, Maysaa</creatorcontrib><creatorcontrib>Drewes, Stephan</creatorcontrib><creatorcontrib>Oltersdorf, Carolin</creatorcontrib><creatorcontrib>Turni, Hendrik</creatorcontrib><creatorcontrib>Imholt, Christian</creatorcontrib><creatorcontrib>Jacob, Jens</creatorcontrib><creatorcontrib>Wagner-Wiening, Christiane</creatorcontrib><creatorcontrib>Ulrich, Rainer G.</creatorcontrib><creatorcontrib>Pfeffer, Martin</creatorcontrib><title>Leptospira spp. in Small Mammals from Areas with Low and High Human Hantavirus Incidences in South-West Germany</title><title>Vector borne and zoonotic diseases (Larchmont, N.Y.)</title><addtitle>Vector Borne Zoonotic Dis</addtitle><description>Introduction:
Leptospirosis is caused by
Leptospira
spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for
Leptospira
spp. and PUUV. Seewis virus (SWSV) is a shrew-borne hantavirus with unknown pathogenicity. The objective of this study was to estimate the prevalence for
Leptospira
spp. and the frequency of
Leptospira
-hantavirus co-infections in small mammals collected at locations with high and low incidences in humans.
Materials and Methods:
In 2012 and 2013, 736 small mammals belonging to seven species (
Apodemus flavicollis
,
Microtus agrestis
,
Microtus arvalis
,
Myodes glareolus
,
Sorex araneus
,
S. coronatus
, and
S. minutus
) were collected at four high incidence sites (H1-H4) and four low (L1-L4) incidence sites for PUUV infection in humans. Kidney-derived DNA samples were tested for
Leptospira
spp. by real-time PCR targeting the
lipl 32
gene and further analyzed by duplex PCR targeting the
flaB
and the
secY
genes. For the detection of Seewis virus, lung-derived DNA was tested via RT-PCR targeting the nucleocapsid gene.
Results:
Altogether, 42 of the 736 small mammals including 27 of 660 bank voles and 11 of 66 shrews, were positive for
Leptospira
spp., while
Sorex
spp. (14.7%) showed significantly higher prevalences compared to bank voles (4.1%). Detected
Leptospira
spp. were pathogenic species other than
L. kirschneri
. Significantly more
Leptospira
-positive bank voles were found at H sites than at L sites. Altogether 22.2% of positive bank voles were infected with PUUV. Double infection of PUUV and
Leptospira
spp. occurrence in bank voles is 1.86 times (OR = 1.86; 95% CI: 0.72–4.73) more likely than infections with each pathogen separately.
Discussion:
Leptospira
- positive bank voles are focally positively associated with PUUV infection in bank voles and with human hantavirus cases. It should be considered that shrews may serve as
Leptospira
spp. reservoirs.</description><subject>Animals</subject><subject>Apodemus flavicollis</subject><subject>Arvicolinae - microbiology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Epidemics</subject><subject>Germany - epidemiology</subject><subject>Hantavirus</subject><subject>Hantavirus Infections - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Kidneys</subject><subject>Leptospira</subject><subject>Leptospira - classification</subject><subject>Leptospira - isolation & purification</subject><subject>Leptospirosis</subject><subject>Leptospirosis - epidemiology</subject><subject>Leptospirosis - veterinary</subject><subject>Lungs</subject><subject>Mammals</subject><subject>Microtus agrestis</subject><subject>Microtus arvalis</subject><subject>Murinae - microbiology</subject><subject>Myodes</subject><subject>Nucleocapsids</subject><subject>Original Articles</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Polymerase chain reaction</subject><subject>Real time</subject><subject>Shrews - microbiology</subject><subject>Small mammals</subject><subject>Sorex</subject><subject>Sorex araneus</subject><subject>Viruses</subject><subject>Zoonoses</subject><issn>1530-3667</issn><issn>1557-7759</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtP3TAYQK2qqDzakbWy1IUlF392_MiIUMtFuogBEGPkOA7XKLFTOwHBr8fppR26sPizraMjWwehYyArIKo6fWpeV5SAyAsTn9ABcC4LKXn1edkzUjAh5D46TOmREAoK-Be0TxVjtKLyAIWNHaeQRhc1TuO4ws7jm0H3Pb7SQ54JdzEM-CxanfCzm7Z4E56x9i1eu4ctXs-D9nit_aSfXJwTvvTGtdYbm_6Ywjxti3ubJnxhY0ZfvqK9Llvtt_d5hO5-_bw9Xxeb64vL87NNYVilpkJzYUtiOdh8NKKRmmgG3ChBJXSEM0YakNpoyoTSVJJKCuhMCS1pbVl27Aid7LxjDL_n_IB6cMnYvtfehjnVUBFRcqUIfIxmqpTASJXRH_-hj2GOPn8kCykDVlKlMlXsKBNDStF29RjdoONLDaReotU5Wr1Eq5domf_-bp2bwbb_6L-VMsB2wHKtve-dbWycPtC-ARODobw</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Obiegala, Anna</creator><creator>Albrecht, Christoph</creator><creator>Dafalla, Maysaa</creator><creator>Drewes, Stephan</creator><creator>Oltersdorf, Carolin</creator><creator>Turni, Hendrik</creator><creator>Imholt, Christian</creator><creator>Jacob, Jens</creator><creator>Wagner-Wiening, Christiane</creator><creator>Ulrich, Rainer G.</creator><creator>Pfeffer, Martin</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7SS</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Leptospira spp. in Small Mammals from Areas with Low and High Human Hantavirus Incidences in South-West Germany</title><author>Obiegala, Anna ; Albrecht, Christoph ; Dafalla, Maysaa ; Drewes, Stephan ; Oltersdorf, Carolin ; Turni, Hendrik ; Imholt, Christian ; Jacob, Jens ; Wagner-Wiening, Christiane ; Ulrich, Rainer G. ; Pfeffer, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-a56e40e51e398c6b7a0a315c86271f05330b17aca2368a2709761fc41d0de44f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Apodemus flavicollis</topic><topic>Arvicolinae - microbiology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Epidemics</topic><topic>Germany - epidemiology</topic><topic>Hantavirus</topic><topic>Hantavirus Infections - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infections</topic><topic>Kidneys</topic><topic>Leptospira</topic><topic>Leptospira - classification</topic><topic>Leptospira - isolation & purification</topic><topic>Leptospirosis</topic><topic>Leptospirosis - epidemiology</topic><topic>Leptospirosis - veterinary</topic><topic>Lungs</topic><topic>Mammals</topic><topic>Microtus agrestis</topic><topic>Microtus arvalis</topic><topic>Murinae - microbiology</topic><topic>Myodes</topic><topic>Nucleocapsids</topic><topic>Original Articles</topic><topic>Pathogenicity</topic><topic>Pathogens</topic><topic>Polymerase chain reaction</topic><topic>Real time</topic><topic>Shrews - microbiology</topic><topic>Small mammals</topic><topic>Sorex</topic><topic>Sorex araneus</topic><topic>Viruses</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obiegala, Anna</creatorcontrib><creatorcontrib>Albrecht, Christoph</creatorcontrib><creatorcontrib>Dafalla, Maysaa</creatorcontrib><creatorcontrib>Drewes, Stephan</creatorcontrib><creatorcontrib>Oltersdorf, Carolin</creatorcontrib><creatorcontrib>Turni, Hendrik</creatorcontrib><creatorcontrib>Imholt, Christian</creatorcontrib><creatorcontrib>Jacob, Jens</creatorcontrib><creatorcontrib>Wagner-Wiening, Christiane</creatorcontrib><creatorcontrib>Ulrich, Rainer G.</creatorcontrib><creatorcontrib>Pfeffer, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obiegala, Anna</au><au>Albrecht, Christoph</au><au>Dafalla, Maysaa</au><au>Drewes, Stephan</au><au>Oltersdorf, Carolin</au><au>Turni, Hendrik</au><au>Imholt, Christian</au><au>Jacob, Jens</au><au>Wagner-Wiening, Christiane</au><au>Ulrich, Rainer G.</au><au>Pfeffer, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptospira spp. in Small Mammals from Areas with Low and High Human Hantavirus Incidences in South-West Germany</atitle><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle><addtitle>Vector Borne Zoonotic Dis</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>17</volume><issue>5</issue><spage>312</spage><epage>318</epage><pages>312-318</pages><issn>1530-3667</issn><eissn>1557-7759</eissn><abstract>Introduction:
Leptospirosis is caused by
Leptospira
spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for
Leptospira
spp. and PUUV. Seewis virus (SWSV) is a shrew-borne hantavirus with unknown pathogenicity. The objective of this study was to estimate the prevalence for
Leptospira
spp. and the frequency of
Leptospira
-hantavirus co-infections in small mammals collected at locations with high and low incidences in humans.
Materials and Methods:
In 2012 and 2013, 736 small mammals belonging to seven species (
Apodemus flavicollis
,
Microtus agrestis
,
Microtus arvalis
,
Myodes glareolus
,
Sorex araneus
,
S. coronatus
, and
S. minutus
) were collected at four high incidence sites (H1-H4) and four low (L1-L4) incidence sites for PUUV infection in humans. Kidney-derived DNA samples were tested for
Leptospira
spp. by real-time PCR targeting the
lipl 32
gene and further analyzed by duplex PCR targeting the
flaB
and the
secY
genes. For the detection of Seewis virus, lung-derived DNA was tested via RT-PCR targeting the nucleocapsid gene.
Results:
Altogether, 42 of the 736 small mammals including 27 of 660 bank voles and 11 of 66 shrews, were positive for
Leptospira
spp., while
Sorex
spp. (14.7%) showed significantly higher prevalences compared to bank voles (4.1%). Detected
Leptospira
spp. were pathogenic species other than
L. kirschneri
. Significantly more
Leptospira
-positive bank voles were found at H sites than at L sites. Altogether 22.2% of positive bank voles were infected with PUUV. Double infection of PUUV and
Leptospira
spp. occurrence in bank voles is 1.86 times (OR = 1.86; 95% CI: 0.72–4.73) more likely than infections with each pathogen separately.
Discussion:
Leptospira
- positive bank voles are focally positively associated with PUUV infection in bank voles and with human hantavirus cases. It should be considered that shrews may serve as
Leptospira
spp. reservoirs.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>28332927</pmid><doi>10.1089/vbz.2016.2036</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-3667 |
| ispartof | Vector borne and zoonotic diseases (Larchmont, N.Y.), 2017-05, Vol.17 (5), p.312-318 |
| issn | 1530-3667 1557-7759 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1906458801 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Apodemus flavicollis Arvicolinae - microbiology Deoxyribonucleic acid DNA Epidemics Germany - epidemiology Hantavirus Hantavirus Infections - epidemiology Humans Incidence Infections Kidneys Leptospira Leptospira - classification Leptospira - isolation & purification Leptospirosis Leptospirosis - epidemiology Leptospirosis - veterinary Lungs Mammals Microtus agrestis Microtus arvalis Murinae - microbiology Myodes Nucleocapsids Original Articles Pathogenicity Pathogens Polymerase chain reaction Real time Shrews - microbiology Small mammals Sorex Sorex araneus Viruses Zoonoses |
| title | Leptospira spp. in Small Mammals from Areas with Low and High Human Hantavirus Incidences in South-West Germany |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T15%3A29%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptospira%20spp.%20in%20Small%20Mammals%20from%20Areas%20with%20Low%20and%20High%20Human%20Hantavirus%20Incidences%20in%20South-West%20Germany&rft.jtitle=Vector%20borne%20and%20zoonotic%20diseases%20(Larchmont,%20N.Y.)&rft.au=Obiegala,%20Anna&rft.date=2017-05-01&rft.volume=17&rft.issue=5&rft.spage=312&rft.epage=318&rft.pages=312-318&rft.issn=1530-3667&rft.eissn=1557-7759&rft_id=info:doi/10.1089/vbz.2016.2036&rft_dat=%3Cproquest_cross%3E1906458801%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1923134288&rft_id=info:pmid/28332927&rfr_iscdi=true |