The NDR/LATS protein kinases in immunology and cancer biology
Abstract The NDR (nuclear Dbf2-related)/LATS (large tumour suppressor) family of kinases represents a subclass of the AGC (protein kinase A (PKA)/PKG/PKC-like) group of serine/threonine protein kinases. Members of the NDR/LATS family are vital components of conserved pathways controlling essential c...
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| Veröffentlicht in: | Seminars in cancer biology 2018-02, Vol.48, p.104-114 |
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| creator | Sharif, Ahmad A.D Hergovich, Alexander |
| description | Abstract The NDR (nuclear Dbf2-related)/LATS (large tumour suppressor) family of kinases represents a subclass of the AGC (protein kinase A (PKA)/PKG/PKC-like) group of serine/threonine protein kinases. Members of the NDR/LATS family are vital components of conserved pathways controlling essential cellular processes, such as proliferation (cell cycle progression) and cell death. In particular, the central involvement of NDR/LATS as YAP/TAZ kinases in the Hippo tissue growth control pathway has gained much interest. In this review, we summarize the roles of mammalian NDR1/2 (aka STK38/STK38L) and LATS1/2 in immunity and cancer biology. We also discuss the activation mechanisms of NDR/LATS involving Ste20-like kinases and the MOB1 signal transducer, followed by an overview of NDR/LATS knockout mouse models. We further review the mutation and expression status of NDR/LATS in human cancers and their possible predictive and/or prognostic value in cancer treatment. |
| doi_str_mv | 10.1016/j.semcancer.2017.04.010 |
| format | Article |
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| subjects | Acyltransferases Adaptor Proteins, Signal Transducing - metabolism AGC kinases Animals Cancer Hematology, Oncology and Palliative Medicine Humans Immunology Large tumour suppressor kinase Mice, Knockout Mutation Neoplasms - enzymology Neoplasms - immunology nuclear Dbf2-related kinase Phosphoproteins - metabolism Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein Serine-Threonine Kinases - physiology Serine/threonine protein kinases Signal Transduction STK38 STK38L Transcription Factors - metabolism Tumor Suppressor Proteins - physiology YAP-Signaling Proteins |
| title | The NDR/LATS protein kinases in immunology and cancer biology |
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