Letrozole, an aromatase inhibitor, reduces post-peak age-related regression of rooster reproductive performance
This study was designed to evaluate orally administrated Letrozole (Lz) on reproductive performance, plasma testosterone and estradiol concentrations and relative abundance of mRNA of GnRH, FSH and LH in roosters. Ross 308 roosters (n=32) that were 40-weeks of age were individually housed and receiv...
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| Veröffentlicht in: | Animal reproduction science 2017-08, Vol.183, p.110-117 |
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| creator | Ali, Emad Abdulgabbar Zhandi, Mahdi Towhidi, Armin Zaghari, Mojtaba Ansari, Mahdi Najafi, Mojtaba Deldar, Hamid |
| description | This study was designed to evaluate orally administrated Letrozole (Lz) on reproductive performance, plasma testosterone and estradiol concentrations and relative abundance of mRNA of GnRH, FSH and LH in roosters. Ross 308 roosters (n=32) that were 40-weeks of age were individually housed and received a basal standard diet supplemented different amounts of capsulated Lz [0 (Lz-0), 0.5 (Lz-0.5), 1 (Lz-1) or 1.5 (Lz-1.5), mg Lz/bird/day] for 12 weeks. Sperm quality variables and plasma testosterone and estradiol concentrations were assessed from the first to the tenth week of the treatment period. Semen samples from the 11th to 12th week were used for artificial insemination and eggs were collected and allotted to assess fertility and hatchability rates. Relative abundance of hypothalamic and pituitary GnRH, LH and FSH mRNA was evaluated at the end of 12th week. The results indicated that total and forward sperm motility as well as egg hatchability rate were greater in the Lz-0.5 group. Greater sperm concentrations, ejaculate volume, sperm plasma membrane integrity, testis index and fertility rates were recorded for both Lz-0.5 and Lz-1 groups compared with the Lz-0 group (P |
| doi_str_mv | 10.1016/j.anireprosci.2017.05.010 |
| format | Article |
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Ross 308 roosters (n=32) that were 40-weeks of age were individually housed and received a basal standard diet supplemented different amounts of capsulated Lz [0 (Lz-0), 0.5 (Lz-0.5), 1 (Lz-1) or 1.5 (Lz-1.5), mg Lz/bird/day] for 12 weeks. Sperm quality variables and plasma testosterone and estradiol concentrations were assessed from the first to the tenth week of the treatment period. Semen samples from the 11th to 12th week were used for artificial insemination and eggs were collected and allotted to assess fertility and hatchability rates. Relative abundance of hypothalamic and pituitary GnRH, LH and FSH mRNA was evaluated at the end of 12th week. The results indicated that total and forward sperm motility as well as egg hatchability rate were greater in the Lz-0.5 group. Greater sperm concentrations, ejaculate volume, sperm plasma membrane integrity, testis index and fertility rates were recorded for both Lz-0.5 and Lz-1 groups compared with the Lz-0 group (P<0.05). Body weight, percentage of sperm abnormalities, and sperm plasma membrane functionality were not affected by treatment. Testosterone and estradiol concentrations were negatively related with greater testosterone concentrations in the Lz-1.5 group which had lesser estradiol concentrations. Relative mRNA transcript abundance for GnRH, LH and FSH was Lz dose responsive being greater in the treated groups; however, this trend plateaued for GnRH and for the relative abundance of both LH and FSH mRNA was less in the Lz-1.5 group than the other treatment groups. It is concluded that Lz may be an effective treatment to improve age related post-peak reproductive performance of roosters.</description><identifier>ISSN: 0378-4320</identifier><identifier>EISSN: 1873-2232</identifier><identifier>DOI: 10.1016/j.anireprosci.2017.05.010</identifier><identifier>PMID: 28578791</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aging - physiology ; Animals ; Chickens ; Estradiol ; Fertility ; Hatchability ; Infertility, Male - drug therapy ; Infertility, Male - veterinary ; Insemination, Artificial ; Lipid Peroxidation ; Male ; Nitriles - pharmacology ; Sperm ; Testosterone ; Triazoles - pharmacology</subject><ispartof>Animal reproduction science, 2017-08, Vol.183, p.110-117</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-9f7733b3abcf57d600391caefc2730e1117c18d6b9ab889cd6c6f1571998814a3</citedby><cites>FETCH-LOGICAL-c377t-9f7733b3abcf57d600391caefc2730e1117c18d6b9ab889cd6c6f1571998814a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anireprosci.2017.05.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28578791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, Emad Abdulgabbar</creatorcontrib><creatorcontrib>Zhandi, Mahdi</creatorcontrib><creatorcontrib>Towhidi, Armin</creatorcontrib><creatorcontrib>Zaghari, Mojtaba</creatorcontrib><creatorcontrib>Ansari, Mahdi</creatorcontrib><creatorcontrib>Najafi, Mojtaba</creatorcontrib><creatorcontrib>Deldar, Hamid</creatorcontrib><title>Letrozole, an aromatase inhibitor, reduces post-peak age-related regression of rooster reproductive performance</title><title>Animal reproduction science</title><addtitle>Anim Reprod Sci</addtitle><description>This study was designed to evaluate orally administrated Letrozole (Lz) on reproductive performance, plasma testosterone and estradiol concentrations and relative abundance of mRNA of GnRH, FSH and LH in roosters. Ross 308 roosters (n=32) that were 40-weeks of age were individually housed and received a basal standard diet supplemented different amounts of capsulated Lz [0 (Lz-0), 0.5 (Lz-0.5), 1 (Lz-1) or 1.5 (Lz-1.5), mg Lz/bird/day] for 12 weeks. Sperm quality variables and plasma testosterone and estradiol concentrations were assessed from the first to the tenth week of the treatment period. Semen samples from the 11th to 12th week were used for artificial insemination and eggs were collected and allotted to assess fertility and hatchability rates. Relative abundance of hypothalamic and pituitary GnRH, LH and FSH mRNA was evaluated at the end of 12th week. The results indicated that total and forward sperm motility as well as egg hatchability rate were greater in the Lz-0.5 group. Greater sperm concentrations, ejaculate volume, sperm plasma membrane integrity, testis index and fertility rates were recorded for both Lz-0.5 and Lz-1 groups compared with the Lz-0 group (P<0.05). Body weight, percentage of sperm abnormalities, and sperm plasma membrane functionality were not affected by treatment. Testosterone and estradiol concentrations were negatively related with greater testosterone concentrations in the Lz-1.5 group which had lesser estradiol concentrations. Relative mRNA transcript abundance for GnRH, LH and FSH was Lz dose responsive being greater in the treated groups; however, this trend plateaued for GnRH and for the relative abundance of both LH and FSH mRNA was less in the Lz-1.5 group than the other treatment groups. It is concluded that Lz may be an effective treatment to improve age related post-peak reproductive performance of roosters.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Chickens</subject><subject>Estradiol</subject><subject>Fertility</subject><subject>Hatchability</subject><subject>Infertility, Male - drug therapy</subject><subject>Infertility, Male - veterinary</subject><subject>Insemination, Artificial</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Nitriles - pharmacology</subject><subject>Sperm</subject><subject>Testosterone</subject><subject>Triazoles - pharmacology</subject><issn>0378-4320</issn><issn>1873-2232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi0EotvCKyBz49CEmXgT20e0aqHSSr2Us-U4k-IliYPtrQRPX5ctiCMnH_z9_8x8jL1HqBGw-3io7eIjrTEk5-sGUNbQ1oDwgm1QSVE1jWhesg0IqaqtaOCMnad0AADZdfo1O2tUK5XUuGFhTzmGX2GiS24XbmOYbbaJuF---d7nEC95pOHoKPE1pFytZL9ze09VpMlmGsrvfaSUfFh4GHkMBaLIf29XYtk_EF8pjiHOdnH0hr0a7ZTo7fN7wb5eX93tvlT72883u0_7ygkpc6VHKYXohe3d2MqhAxAanaXRNVIAIaJ0qIau17ZXSruhc92IrUStlcKtFRfsw6m3rPHjSCmb2SdH02QXCsdkUEOH21Ztm4LqE-qKzxRpNGv0s40_DYJ58m0O5h_f5sm3gdYU3yX77nnMsZ9p-Jv8I7gAuxNA5dgHT9GUCioihlLoshmC_48xj4z1mhA</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Ali, Emad Abdulgabbar</creator><creator>Zhandi, Mahdi</creator><creator>Towhidi, Armin</creator><creator>Zaghari, Mojtaba</creator><creator>Ansari, Mahdi</creator><creator>Najafi, Mojtaba</creator><creator>Deldar, Hamid</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Letrozole, an aromatase inhibitor, reduces post-peak age-related regression of rooster reproductive performance</title><author>Ali, Emad Abdulgabbar ; Zhandi, Mahdi ; Towhidi, Armin ; Zaghari, Mojtaba ; Ansari, Mahdi ; Najafi, Mojtaba ; Deldar, Hamid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-9f7733b3abcf57d600391caefc2730e1117c18d6b9ab889cd6c6f1571998814a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Chickens</topic><topic>Estradiol</topic><topic>Fertility</topic><topic>Hatchability</topic><topic>Infertility, Male - drug therapy</topic><topic>Infertility, Male - veterinary</topic><topic>Insemination, Artificial</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Nitriles - pharmacology</topic><topic>Sperm</topic><topic>Testosterone</topic><topic>Triazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, Emad Abdulgabbar</creatorcontrib><creatorcontrib>Zhandi, Mahdi</creatorcontrib><creatorcontrib>Towhidi, Armin</creatorcontrib><creatorcontrib>Zaghari, Mojtaba</creatorcontrib><creatorcontrib>Ansari, Mahdi</creatorcontrib><creatorcontrib>Najafi, Mojtaba</creatorcontrib><creatorcontrib>Deldar, Hamid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Animal reproduction science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, Emad Abdulgabbar</au><au>Zhandi, Mahdi</au><au>Towhidi, Armin</au><au>Zaghari, Mojtaba</au><au>Ansari, Mahdi</au><au>Najafi, Mojtaba</au><au>Deldar, Hamid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Letrozole, an aromatase inhibitor, reduces post-peak age-related regression of rooster reproductive performance</atitle><jtitle>Animal reproduction science</jtitle><addtitle>Anim Reprod Sci</addtitle><date>2017-08</date><risdate>2017</risdate><volume>183</volume><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>0378-4320</issn><eissn>1873-2232</eissn><abstract>This study was designed to evaluate orally administrated Letrozole (Lz) on reproductive performance, plasma testosterone and estradiol concentrations and relative abundance of mRNA of GnRH, FSH and LH in roosters. Ross 308 roosters (n=32) that were 40-weeks of age were individually housed and received a basal standard diet supplemented different amounts of capsulated Lz [0 (Lz-0), 0.5 (Lz-0.5), 1 (Lz-1) or 1.5 (Lz-1.5), mg Lz/bird/day] for 12 weeks. Sperm quality variables and plasma testosterone and estradiol concentrations were assessed from the first to the tenth week of the treatment period. Semen samples from the 11th to 12th week were used for artificial insemination and eggs were collected and allotted to assess fertility and hatchability rates. Relative abundance of hypothalamic and pituitary GnRH, LH and FSH mRNA was evaluated at the end of 12th week. The results indicated that total and forward sperm motility as well as egg hatchability rate were greater in the Lz-0.5 group. Greater sperm concentrations, ejaculate volume, sperm plasma membrane integrity, testis index and fertility rates were recorded for both Lz-0.5 and Lz-1 groups compared with the Lz-0 group (P<0.05). Body weight, percentage of sperm abnormalities, and sperm plasma membrane functionality were not affected by treatment. Testosterone and estradiol concentrations were negatively related with greater testosterone concentrations in the Lz-1.5 group which had lesser estradiol concentrations. Relative mRNA transcript abundance for GnRH, LH and FSH was Lz dose responsive being greater in the treated groups; however, this trend plateaued for GnRH and for the relative abundance of both LH and FSH mRNA was less in the Lz-1.5 group than the other treatment groups. It is concluded that Lz may be an effective treatment to improve age related post-peak reproductive performance of roosters.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28578791</pmid><doi>10.1016/j.anireprosci.2017.05.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Aging - physiology Animals Chickens Estradiol Fertility Hatchability Infertility, Male - drug therapy Infertility, Male - veterinary Insemination, Artificial Lipid Peroxidation Male Nitriles - pharmacology Sperm Testosterone Triazoles - pharmacology |
| title | Letrozole, an aromatase inhibitor, reduces post-peak age-related regression of rooster reproductive performance |
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