Outcomes After Endovascular Revascularization in Octogenarians and Non-Octogenarians With Critical Limb Ischemia
Purpose: To determine the outcome and periprocedural risk of endovascular revascularization in octogenarians with critical limb ischemia (CLI) compared with their younger counterparts. Methods: The multicenter, prospective registry for First-line Treatments in Patients With Critical Limb Ischemia (C...
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| Veröffentlicht in: | Journal of endovascular therapy 2017-08, Vol.24 (4), p.471-477 |
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| creator | Uhl, Christian Steinbauer, Markus Torsello, Giovanni Bisdas, Theodosios Adili, Farzin Balzer, Kai Billing, Arend Böckler, Dittmar Brixner, Daniel Debus, Sebastian E. Eckstein, Hans-Henning Florek, Hans-Joachim Gkremoutis, Asimakis Grundmann, Reinhardt Hupp, Thomas Hwang, Se-Won Keck, Tobias Wojciech, Klonek Lang, Werner May, Björn Meyer, Alexander Mühling, Bernhard Oberhuber, Alexander Reinecke, Holger Reinhold, Christian Ritter, Ralf-Gerhard Schelzig, Hubert Schlensack, Christian Schmitz-Rixen, Thomas Schulte, Karl-Ludwig Spohn, Matthias Stavroulakis, Konstantinos Storck, Martin Trede, Matthias Weis-Müller, Barbara Wenk, Heiner Zeller, Thomas Zhorzel, Sven Zimmermann, Alexander |
| description | Purpose: To determine the outcome and periprocedural risk of endovascular revascularization in octogenarians with critical limb ischemia (CLI) compared with their younger counterparts. Methods: The multicenter, prospective registry for First-line Treatments in Patients With Critical Limb Ischemia (CRITISCH) enrolled 642 patients treated with endovascular techniques (
ClinicalTrials.gov
identifier NCT01877252). The patients were dichotomized according to age |
| doi_str_mv | 10.1177/1526602817711424 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1906143976</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1526602817711424</sage_id><sourcerecordid>1906143976</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-68eaf1fbba71e9ac84c7f500b80949fe8081d4ebe03b94976d0bbbe7d2365353</originalsourceid><addsrcrecordid>eNp1kMFLwzAYxYMoTqd3T5Kjl2q-tGm74xhTB8OBDDyWJP26ZbTJTFpB_3o7tgkKnvJ4-b0H3yPkBtg9QJY9gOBpynjea4CEJyfkAkQiIhCCne40T6Pd_4BchrBhjAMHOCcDnossT3lyQbaLrtWuwUDHVYueTm3pPmTQXS09fcWjNF-yNc5SY-lCt26FtvekDVTakr44G_1230y7phNvWqNlTeemUXQW9BobI6_IWSXrgNeHd0iWj9Pl5DmaL55mk_E80nGctVGao6ygUkpmgCOp80RnlWBM5WyUjCrMWQ5lggpZrHojS0umlMKs5HEqYhEPyd2-duvde4ehLRoTNNa1tOi6UMCIpZDEfbBH2R7V3oXgsSq23jTSfxbAit3Mxd-Z-8jtob1TDZY_geOuPRDtgSBXWGxc521_7P-F33HVhks</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1906143976</pqid></control><display><type>article</type><title>Outcomes After Endovascular Revascularization in Octogenarians and Non-Octogenarians With Critical Limb Ischemia</title><source>SAGE Complete A-Z List</source><creator>Uhl, Christian ; Steinbauer, Markus ; Torsello, Giovanni ; Bisdas, Theodosios ; Adili, Farzin ; Balzer, Kai ; Billing, Arend ; Böckler, Dittmar ; Brixner, Daniel ; Debus, Sebastian E. ; Eckstein, Hans-Henning ; Florek, Hans-Joachim ; Gkremoutis, Asimakis ; Grundmann, Reinhardt ; Hupp, Thomas ; Hwang, Se-Won ; Keck, Tobias ; Wojciech, Klonek ; Lang, Werner ; May, Björn ; Meyer, Alexander ; Mühling, Bernhard ; Oberhuber, Alexander ; Reinecke, Holger ; Reinhold, Christian ; Ritter, Ralf-Gerhard ; Schelzig, Hubert ; Schlensack, Christian ; Schmitz-Rixen, Thomas ; Schulte, Karl-Ludwig ; Spohn, Matthias ; Stavroulakis, Konstantinos ; Storck, Martin ; Trede, Matthias ; Weis-Müller, Barbara ; Wenk, Heiner ; Zeller, Thomas ; Zhorzel, Sven ; Zimmermann, Alexander</creator><creatorcontrib>Uhl, Christian ; Steinbauer, Markus ; Torsello, Giovanni ; Bisdas, Theodosios ; Adili, Farzin ; Balzer, Kai ; Billing, Arend ; Böckler, Dittmar ; Brixner, Daniel ; Debus, Sebastian E. ; Eckstein, Hans-Henning ; Florek, Hans-Joachim ; Gkremoutis, Asimakis ; Grundmann, Reinhardt ; Hupp, Thomas ; Hwang, Se-Won ; Keck, Tobias ; Wojciech, Klonek ; Lang, Werner ; May, Björn ; Meyer, Alexander ; Mühling, Bernhard ; Oberhuber, Alexander ; Reinecke, Holger ; Reinhold, Christian ; Ritter, Ralf-Gerhard ; Schelzig, Hubert ; Schlensack, Christian ; Schmitz-Rixen, Thomas ; Schulte, Karl-Ludwig ; Spohn, Matthias ; Stavroulakis, Konstantinos ; Storck, Martin ; Trede, Matthias ; Weis-Müller, Barbara ; Wenk, Heiner ; Zeller, Thomas ; Zhorzel, Sven ; Zimmermann, Alexander ; The CRITISCH collaborators ; for the CRITISCH collaborators</creatorcontrib><description>Purpose: To determine the outcome and periprocedural risk of endovascular revascularization in octogenarians with critical limb ischemia (CLI) compared with their younger counterparts. Methods: The multicenter, prospective registry for First-line Treatments in Patients With Critical Limb Ischemia (CRITISCH) enrolled 642 patients treated with endovascular techniques (
ClinicalTrials.gov
identifier NCT01877252). The patients were dichotomized according to age <80 years (n=421; mean age 69 years, 292 men; group 1) or ≥80 years (n=221; mean age 85 years, 113 men; group 2). The groups had similar distributions in Rutherford categories 4 to 6, but group 1 had more men, smokers, diabetics, and patients on dialysis. The primary composite endpoint of the study was amputation and/or death. Key secondary endpoints were in-hospital mortality and major amputation, as well as major adverse limb events (MALE; any reintervention or major amputation involving the index limb) at 1 year. Results: The in-hospital mortality was 1% in group 1 and 2% in group 2 (p=0.204) and the major amputation rates were 4% and 2% (p=0.169), respectively. Amputation-free survival at 1 year was 75% in group 1 and 77% in group 2 (p=0.340), whereas freedom from MALE was significantly different between the groups [62% group 1 vs 72% group 2; hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.09 to 1.93, p=0.016). Limb salvage was 90% in group 1 and 95% in group 2 (HR 2.16, 95% CI 1.27 to 3.69, p=0.01). Conclusion: Octogenarians with CLI treated by endovascular means showed comparable early and 1-year amputation-free survival rates vs their younger counterparts, and limb salvage and freedom from MALE rates were even higher in octogenarians.</description><identifier>ISSN: 1526-6028</identifier><identifier>EISSN: 1545-1550</identifier><identifier>DOI: 10.1177/1526602817711424</identifier><identifier>PMID: 28578624</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><ispartof>Journal of endovascular therapy, 2017-08, Vol.24 (4), p.471-477</ispartof><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-68eaf1fbba71e9ac84c7f500b80949fe8081d4ebe03b94976d0bbbe7d2365353</citedby><cites>FETCH-LOGICAL-c337t-68eaf1fbba71e9ac84c7f500b80949fe8081d4ebe03b94976d0bbbe7d2365353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1526602817711424$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1526602817711424$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28578624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uhl, Christian</creatorcontrib><creatorcontrib>Steinbauer, Markus</creatorcontrib><creatorcontrib>Torsello, Giovanni</creatorcontrib><creatorcontrib>Bisdas, Theodosios</creatorcontrib><creatorcontrib>Adili, Farzin</creatorcontrib><creatorcontrib>Balzer, Kai</creatorcontrib><creatorcontrib>Billing, Arend</creatorcontrib><creatorcontrib>Böckler, Dittmar</creatorcontrib><creatorcontrib>Brixner, Daniel</creatorcontrib><creatorcontrib>Debus, Sebastian E.</creatorcontrib><creatorcontrib>Eckstein, Hans-Henning</creatorcontrib><creatorcontrib>Florek, Hans-Joachim</creatorcontrib><creatorcontrib>Gkremoutis, Asimakis</creatorcontrib><creatorcontrib>Grundmann, Reinhardt</creatorcontrib><creatorcontrib>Hupp, Thomas</creatorcontrib><creatorcontrib>Hwang, Se-Won</creatorcontrib><creatorcontrib>Keck, Tobias</creatorcontrib><creatorcontrib>Wojciech, Klonek</creatorcontrib><creatorcontrib>Lang, Werner</creatorcontrib><creatorcontrib>May, Björn</creatorcontrib><creatorcontrib>Meyer, Alexander</creatorcontrib><creatorcontrib>Mühling, Bernhard</creatorcontrib><creatorcontrib>Oberhuber, Alexander</creatorcontrib><creatorcontrib>Reinecke, Holger</creatorcontrib><creatorcontrib>Reinhold, Christian</creatorcontrib><creatorcontrib>Ritter, Ralf-Gerhard</creatorcontrib><creatorcontrib>Schelzig, Hubert</creatorcontrib><creatorcontrib>Schlensack, Christian</creatorcontrib><creatorcontrib>Schmitz-Rixen, Thomas</creatorcontrib><creatorcontrib>Schulte, Karl-Ludwig</creatorcontrib><creatorcontrib>Spohn, Matthias</creatorcontrib><creatorcontrib>Stavroulakis, Konstantinos</creatorcontrib><creatorcontrib>Storck, Martin</creatorcontrib><creatorcontrib>Trede, Matthias</creatorcontrib><creatorcontrib>Weis-Müller, Barbara</creatorcontrib><creatorcontrib>Wenk, Heiner</creatorcontrib><creatorcontrib>Zeller, Thomas</creatorcontrib><creatorcontrib>Zhorzel, Sven</creatorcontrib><creatorcontrib>Zimmermann, Alexander</creatorcontrib><creatorcontrib>The CRITISCH collaborators</creatorcontrib><creatorcontrib>for the CRITISCH collaborators</creatorcontrib><title>Outcomes After Endovascular Revascularization in Octogenarians and Non-Octogenarians With Critical Limb Ischemia</title><title>Journal of endovascular therapy</title><addtitle>J Endovasc Ther</addtitle><description>Purpose: To determine the outcome and periprocedural risk of endovascular revascularization in octogenarians with critical limb ischemia (CLI) compared with their younger counterparts. Methods: The multicenter, prospective registry for First-line Treatments in Patients With Critical Limb Ischemia (CRITISCH) enrolled 642 patients treated with endovascular techniques (
ClinicalTrials.gov
identifier NCT01877252). The patients were dichotomized according to age <80 years (n=421; mean age 69 years, 292 men; group 1) or ≥80 years (n=221; mean age 85 years, 113 men; group 2). The groups had similar distributions in Rutherford categories 4 to 6, but group 1 had more men, smokers, diabetics, and patients on dialysis. The primary composite endpoint of the study was amputation and/or death. Key secondary endpoints were in-hospital mortality and major amputation, as well as major adverse limb events (MALE; any reintervention or major amputation involving the index limb) at 1 year. Results: The in-hospital mortality was 1% in group 1 and 2% in group 2 (p=0.204) and the major amputation rates were 4% and 2% (p=0.169), respectively. Amputation-free survival at 1 year was 75% in group 1 and 77% in group 2 (p=0.340), whereas freedom from MALE was significantly different between the groups [62% group 1 vs 72% group 2; hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.09 to 1.93, p=0.016). Limb salvage was 90% in group 1 and 95% in group 2 (HR 2.16, 95% CI 1.27 to 3.69, p=0.01). Conclusion: Octogenarians with CLI treated by endovascular means showed comparable early and 1-year amputation-free survival rates vs their younger counterparts, and limb salvage and freedom from MALE rates were even higher in octogenarians.</description><issn>1526-6028</issn><issn>1545-1550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kMFLwzAYxYMoTqd3T5Kjl2q-tGm74xhTB8OBDDyWJP26ZbTJTFpB_3o7tgkKnvJ4-b0H3yPkBtg9QJY9gOBpynjea4CEJyfkAkQiIhCCne40T6Pd_4BchrBhjAMHOCcDnossT3lyQbaLrtWuwUDHVYueTm3pPmTQXS09fcWjNF-yNc5SY-lCt26FtvekDVTakr44G_1230y7phNvWqNlTeemUXQW9BobI6_IWSXrgNeHd0iWj9Pl5DmaL55mk_E80nGctVGao6ygUkpmgCOp80RnlWBM5WyUjCrMWQ5lggpZrHojS0umlMKs5HEqYhEPyd2-duvde4ehLRoTNNa1tOi6UMCIpZDEfbBH2R7V3oXgsSq23jTSfxbAit3Mxd-Z-8jtob1TDZY_geOuPRDtgSBXWGxc521_7P-F33HVhks</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Uhl, Christian</creator><creator>Steinbauer, Markus</creator><creator>Torsello, Giovanni</creator><creator>Bisdas, Theodosios</creator><creator>Adili, Farzin</creator><creator>Balzer, Kai</creator><creator>Billing, Arend</creator><creator>Böckler, Dittmar</creator><creator>Brixner, Daniel</creator><creator>Debus, Sebastian E.</creator><creator>Eckstein, Hans-Henning</creator><creator>Florek, Hans-Joachim</creator><creator>Gkremoutis, Asimakis</creator><creator>Grundmann, Reinhardt</creator><creator>Hupp, Thomas</creator><creator>Hwang, Se-Won</creator><creator>Keck, Tobias</creator><creator>Wojciech, Klonek</creator><creator>Lang, Werner</creator><creator>May, Björn</creator><creator>Meyer, Alexander</creator><creator>Mühling, Bernhard</creator><creator>Oberhuber, Alexander</creator><creator>Reinecke, Holger</creator><creator>Reinhold, Christian</creator><creator>Ritter, Ralf-Gerhard</creator><creator>Schelzig, Hubert</creator><creator>Schlensack, Christian</creator><creator>Schmitz-Rixen, Thomas</creator><creator>Schulte, Karl-Ludwig</creator><creator>Spohn, Matthias</creator><creator>Stavroulakis, Konstantinos</creator><creator>Storck, Martin</creator><creator>Trede, Matthias</creator><creator>Weis-Müller, Barbara</creator><creator>Wenk, Heiner</creator><creator>Zeller, Thomas</creator><creator>Zhorzel, Sven</creator><creator>Zimmermann, Alexander</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Outcomes After Endovascular Revascularization in Octogenarians and Non-Octogenarians With Critical Limb Ischemia</title><author>Uhl, Christian ; Steinbauer, Markus ; Torsello, Giovanni ; Bisdas, Theodosios ; Adili, Farzin ; Balzer, Kai ; Billing, Arend ; Böckler, Dittmar ; Brixner, Daniel ; Debus, Sebastian E. ; Eckstein, Hans-Henning ; Florek, Hans-Joachim ; Gkremoutis, Asimakis ; Grundmann, Reinhardt ; Hupp, Thomas ; Hwang, Se-Won ; Keck, Tobias ; Wojciech, Klonek ; Lang, Werner ; May, Björn ; Meyer, Alexander ; Mühling, Bernhard ; Oberhuber, Alexander ; Reinecke, Holger ; Reinhold, Christian ; Ritter, Ralf-Gerhard ; Schelzig, Hubert ; Schlensack, Christian ; Schmitz-Rixen, Thomas ; Schulte, Karl-Ludwig ; Spohn, Matthias ; Stavroulakis, Konstantinos ; Storck, Martin ; Trede, Matthias ; Weis-Müller, Barbara ; Wenk, Heiner ; Zeller, Thomas ; Zhorzel, Sven ; Zimmermann, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-68eaf1fbba71e9ac84c7f500b80949fe8081d4ebe03b94976d0bbbe7d2365353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uhl, Christian</creatorcontrib><creatorcontrib>Steinbauer, Markus</creatorcontrib><creatorcontrib>Torsello, Giovanni</creatorcontrib><creatorcontrib>Bisdas, Theodosios</creatorcontrib><creatorcontrib>Adili, 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Christian</creatorcontrib><creatorcontrib>Ritter, Ralf-Gerhard</creatorcontrib><creatorcontrib>Schelzig, Hubert</creatorcontrib><creatorcontrib>Schlensack, Christian</creatorcontrib><creatorcontrib>Schmitz-Rixen, Thomas</creatorcontrib><creatorcontrib>Schulte, Karl-Ludwig</creatorcontrib><creatorcontrib>Spohn, Matthias</creatorcontrib><creatorcontrib>Stavroulakis, Konstantinos</creatorcontrib><creatorcontrib>Storck, Martin</creatorcontrib><creatorcontrib>Trede, Matthias</creatorcontrib><creatorcontrib>Weis-Müller, Barbara</creatorcontrib><creatorcontrib>Wenk, Heiner</creatorcontrib><creatorcontrib>Zeller, Thomas</creatorcontrib><creatorcontrib>Zhorzel, Sven</creatorcontrib><creatorcontrib>Zimmermann, Alexander</creatorcontrib><creatorcontrib>The CRITISCH collaborators</creatorcontrib><creatorcontrib>for the CRITISCH collaborators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endovascular therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uhl, Christian</au><au>Steinbauer, Markus</au><au>Torsello, Giovanni</au><au>Bisdas, Theodosios</au><au>Adili, Farzin</au><au>Balzer, Kai</au><au>Billing, Arend</au><au>Böckler, Dittmar</au><au>Brixner, Daniel</au><au>Debus, Sebastian E.</au><au>Eckstein, Hans-Henning</au><au>Florek, Hans-Joachim</au><au>Gkremoutis, Asimakis</au><au>Grundmann, Reinhardt</au><au>Hupp, Thomas</au><au>Hwang, Se-Won</au><au>Keck, Tobias</au><au>Wojciech, Klonek</au><au>Lang, Werner</au><au>May, Björn</au><au>Meyer, Alexander</au><au>Mühling, Bernhard</au><au>Oberhuber, Alexander</au><au>Reinecke, Holger</au><au>Reinhold, Christian</au><au>Ritter, Ralf-Gerhard</au><au>Schelzig, Hubert</au><au>Schlensack, Christian</au><au>Schmitz-Rixen, Thomas</au><au>Schulte, Karl-Ludwig</au><au>Spohn, Matthias</au><au>Stavroulakis, Konstantinos</au><au>Storck, Martin</au><au>Trede, Matthias</au><au>Weis-Müller, Barbara</au><au>Wenk, Heiner</au><au>Zeller, Thomas</au><au>Zhorzel, Sven</au><au>Zimmermann, Alexander</au><aucorp>The CRITISCH collaborators</aucorp><aucorp>for the CRITISCH collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes After Endovascular Revascularization in Octogenarians and Non-Octogenarians With Critical Limb Ischemia</atitle><jtitle>Journal of endovascular therapy</jtitle><addtitle>J Endovasc Ther</addtitle><date>2017-08</date><risdate>2017</risdate><volume>24</volume><issue>4</issue><spage>471</spage><epage>477</epage><pages>471-477</pages><issn>1526-6028</issn><eissn>1545-1550</eissn><abstract>Purpose: To determine the outcome and periprocedural risk of endovascular revascularization in octogenarians with critical limb ischemia (CLI) compared with their younger counterparts. Methods: The multicenter, prospective registry for First-line Treatments in Patients With Critical Limb Ischemia (CRITISCH) enrolled 642 patients treated with endovascular techniques (
ClinicalTrials.gov
identifier NCT01877252). The patients were dichotomized according to age <80 years (n=421; mean age 69 years, 292 men; group 1) or ≥80 years (n=221; mean age 85 years, 113 men; group 2). The groups had similar distributions in Rutherford categories 4 to 6, but group 1 had more men, smokers, diabetics, and patients on dialysis. The primary composite endpoint of the study was amputation and/or death. Key secondary endpoints were in-hospital mortality and major amputation, as well as major adverse limb events (MALE; any reintervention or major amputation involving the index limb) at 1 year. Results: The in-hospital mortality was 1% in group 1 and 2% in group 2 (p=0.204) and the major amputation rates were 4% and 2% (p=0.169), respectively. Amputation-free survival at 1 year was 75% in group 1 and 77% in group 2 (p=0.340), whereas freedom from MALE was significantly different between the groups [62% group 1 vs 72% group 2; hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.09 to 1.93, p=0.016). Limb salvage was 90% in group 1 and 95% in group 2 (HR 2.16, 95% CI 1.27 to 3.69, p=0.01). Conclusion: Octogenarians with CLI treated by endovascular means showed comparable early and 1-year amputation-free survival rates vs their younger counterparts, and limb salvage and freedom from MALE rates were even higher in octogenarians.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28578624</pmid><doi>10.1177/1526602817711424</doi><tpages>7</tpages></addata></record> |
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| title | Outcomes After Endovascular Revascularization in Octogenarians and Non-Octogenarians With Critical Limb Ischemia |
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