Management of Low Grade Cervical Mullerian Adenosarcoma in a 14-year-old Girl
Abstract Background Mullerian adenosarcomas of the cervix are composed of benign epithelial and malignant stromal components. The purpose of this report is to describe the clinical and histologic difficulties in diagnosis and to propose fertility preserving management of low grade lesions. Case A 14...
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| Veröffentlicht in: | Journal of pediatric & adolescent gynecology 2017-12, Vol.30 (6), p.652-654 |
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| container_title | Journal of pediatric & adolescent gynecology |
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| creator | Shinnick, Julia K., MD Kumar, Natasha, BA Beffa, Lindsey, MD Miller, Katherine, MD Friedman, Mary Alexandra M., MD Kalife, Elizabeth, MD DiSilvestro, Paul, MD Mathews, Cara, MD |
| description | Abstract Background Mullerian adenosarcomas of the cervix are composed of benign epithelial and malignant stromal components. The purpose of this report is to describe the clinical and histologic difficulties in diagnosis and to propose fertility preserving management of low grade lesions. Case A 14-year-old girl presented with a friable lesion found to originate from the anterior cervical lip. Initially, clinical suspicion was for sarcoma botryoides, however, pathologic evaluation revealed a low grade cervical Mullerian adenosarcoma. Cold knife conization was performed, and the mass was resected with clear margins. Summary and Conclusion Mullerian adenosarcoma of the cervix is difficult to diagnose in adolescents due to features more commonly associated with alternative diagnoses. For patients with low grade lesions desiring future fertility, local excision with close follow-up is reasonable. |
| doi_str_mv | 10.1016/j.jpag.2017.05.010 |
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The purpose of this report is to describe the clinical and histologic difficulties in diagnosis and to propose fertility preserving management of low grade lesions. Case A 14-year-old girl presented with a friable lesion found to originate from the anterior cervical lip. Initially, clinical suspicion was for sarcoma botryoides, however, pathologic evaluation revealed a low grade cervical Mullerian adenosarcoma. Cold knife conization was performed, and the mass was resected with clear margins. Summary and Conclusion Mullerian adenosarcoma of the cervix is difficult to diagnose in adolescents due to features more commonly associated with alternative diagnoses. For patients with low grade lesions desiring future fertility, local excision with close follow-up is reasonable.</description><identifier>ISSN: 1083-3188</identifier><identifier>EISSN: 1873-4332</identifier><identifier>DOI: 10.1016/j.jpag.2017.05.010</identifier><identifier>PMID: 28578185</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenosarcoma - diagnosis ; Adenosarcoma - therapy ; Adolescent ; Conization - methods ; Female ; Humans ; Müllerian adenosarcoma ; Obstetrics and Gynecology ; Pediatric gynecologic cancer ; Pediatrics ; Uterine cervical neoplasm ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - therapy ; Uterine Neoplasms - diagnosis ; Uterine Neoplasms - therapy</subject><ispartof>Journal of pediatric & adolescent gynecology, 2017-12, Vol.30 (6), p.652-654</ispartof><rights>2017 North American Society for Pediatric and Adolescent Gynecology</rights><rights>Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-6be7463be30a383394ed81faf8ecfa67a42b720a2673abd3a6f7f14b6d58a1183</citedby><cites>FETCH-LOGICAL-c411t-6be7463be30a383394ed81faf8ecfa67a42b720a2673abd3a6f7f14b6d58a1183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1083318817300967$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28578185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinnick, Julia K., MD</creatorcontrib><creatorcontrib>Kumar, Natasha, BA</creatorcontrib><creatorcontrib>Beffa, Lindsey, MD</creatorcontrib><creatorcontrib>Miller, Katherine, MD</creatorcontrib><creatorcontrib>Friedman, Mary Alexandra M., MD</creatorcontrib><creatorcontrib>Kalife, Elizabeth, MD</creatorcontrib><creatorcontrib>DiSilvestro, Paul, MD</creatorcontrib><creatorcontrib>Mathews, Cara, MD</creatorcontrib><title>Management of Low Grade Cervical Mullerian Adenosarcoma in a 14-year-old Girl</title><title>Journal of pediatric & adolescent gynecology</title><addtitle>J Pediatr Adolesc Gynecol</addtitle><description>Abstract Background Mullerian adenosarcomas of the cervix are composed of benign epithelial and malignant stromal components. The purpose of this report is to describe the clinical and histologic difficulties in diagnosis and to propose fertility preserving management of low grade lesions. Case A 14-year-old girl presented with a friable lesion found to originate from the anterior cervical lip. Initially, clinical suspicion was for sarcoma botryoides, however, pathologic evaluation revealed a low grade cervical Mullerian adenosarcoma. Cold knife conization was performed, and the mass was resected with clear margins. Summary and Conclusion Mullerian adenosarcoma of the cervix is difficult to diagnose in adolescents due to features more commonly associated with alternative diagnoses. For patients with low grade lesions desiring future fertility, local excision with close follow-up is reasonable.</description><subject>Adenosarcoma - diagnosis</subject><subject>Adenosarcoma - therapy</subject><subject>Adolescent</subject><subject>Conization - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Müllerian adenosarcoma</subject><subject>Obstetrics and Gynecology</subject><subject>Pediatric gynecologic cancer</subject><subject>Pediatrics</subject><subject>Uterine cervical neoplasm</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - therapy</subject><subject>Uterine Neoplasms - diagnosis</subject><subject>Uterine Neoplasms - therapy</subject><issn>1083-3188</issn><issn>1873-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kbGO1DAQhi0E4o6DF6BALmkSPHFieyWEdFrBgrQrCqC2Jvbk5JDEi7250749ifagoKCaKb7_l-Ybxl6DKEGAeteX_RHvykqALkVTChBP2DUYLYtayurpsgsjCwnGXLEXOfdCCN0o85xdVabRBkxzzQ4HnPCORppOPHZ8Hx_4LqEnvqV0HxwO_DAPA6WAE7_1NMWMycUReZg4cqiLM2Eq4uD5LqThJXvW4ZDp1eO8YT8-ffy-_Vzsv-6-bG_3hasBToVqSddKtiQFSiPlpiZvoMPOkOtQaayrVlcCK6Ultl6i6nQHdat8YxDAyBv29tJ7TPHXTPlkx5AdDQNOFOdsYSMU1HLTrGh1QV2KOSfq7DGFEdPZgrCrRtvbVaNdNVrR2EXjEnrz2D-3I_m_kT_eFuD9BaDlyvtAyWYXaHLkQyJ3sj6G__d_-CfuhjCtun_SmXIf5zQt_izYXFlhv62PXP8IWgqxWaz8Btw1lvE</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Shinnick, Julia K., MD</creator><creator>Kumar, Natasha, BA</creator><creator>Beffa, Lindsey, MD</creator><creator>Miller, Katherine, MD</creator><creator>Friedman, Mary Alexandra M., MD</creator><creator>Kalife, Elizabeth, MD</creator><creator>DiSilvestro, Paul, MD</creator><creator>Mathews, Cara, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>Management of Low Grade Cervical Mullerian Adenosarcoma in a 14-year-old Girl</title><author>Shinnick, Julia K., MD ; Kumar, Natasha, BA ; Beffa, Lindsey, MD ; Miller, Katherine, MD ; Friedman, Mary Alexandra M., MD ; Kalife, Elizabeth, MD ; DiSilvestro, Paul, MD ; Mathews, Cara, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-6be7463be30a383394ed81faf8ecfa67a42b720a2673abd3a6f7f14b6d58a1183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenosarcoma - diagnosis</topic><topic>Adenosarcoma - therapy</topic><topic>Adolescent</topic><topic>Conization - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Müllerian adenosarcoma</topic><topic>Obstetrics and Gynecology</topic><topic>Pediatric gynecologic cancer</topic><topic>Pediatrics</topic><topic>Uterine cervical neoplasm</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - therapy</topic><topic>Uterine Neoplasms - diagnosis</topic><topic>Uterine Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinnick, Julia K., MD</creatorcontrib><creatorcontrib>Kumar, Natasha, BA</creatorcontrib><creatorcontrib>Beffa, Lindsey, MD</creatorcontrib><creatorcontrib>Miller, Katherine, MD</creatorcontrib><creatorcontrib>Friedman, Mary Alexandra M., MD</creatorcontrib><creatorcontrib>Kalife, Elizabeth, MD</creatorcontrib><creatorcontrib>DiSilvestro, Paul, MD</creatorcontrib><creatorcontrib>Mathews, Cara, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric & adolescent gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinnick, Julia K., MD</au><au>Kumar, Natasha, BA</au><au>Beffa, Lindsey, MD</au><au>Miller, Katherine, MD</au><au>Friedman, Mary Alexandra M., MD</au><au>Kalife, Elizabeth, MD</au><au>DiSilvestro, Paul, MD</au><au>Mathews, Cara, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of Low Grade Cervical Mullerian Adenosarcoma in a 14-year-old Girl</atitle><jtitle>Journal of pediatric & adolescent gynecology</jtitle><addtitle>J Pediatr Adolesc Gynecol</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>30</volume><issue>6</issue><spage>652</spage><epage>654</epage><pages>652-654</pages><issn>1083-3188</issn><eissn>1873-4332</eissn><abstract>Abstract Background Mullerian adenosarcomas of the cervix are composed of benign epithelial and malignant stromal components. The purpose of this report is to describe the clinical and histologic difficulties in diagnosis and to propose fertility preserving management of low grade lesions. Case A 14-year-old girl presented with a friable lesion found to originate from the anterior cervical lip. Initially, clinical suspicion was for sarcoma botryoides, however, pathologic evaluation revealed a low grade cervical Mullerian adenosarcoma. Cold knife conization was performed, and the mass was resected with clear margins. Summary and Conclusion Mullerian adenosarcoma of the cervix is difficult to diagnose in adolescents due to features more commonly associated with alternative diagnoses. For patients with low grade lesions desiring future fertility, local excision with close follow-up is reasonable.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28578185</pmid><doi>10.1016/j.jpag.2017.05.010</doi><tpages>3</tpages></addata></record> |
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| subjects | Adenosarcoma - diagnosis Adenosarcoma - therapy Adolescent Conization - methods Female Humans Müllerian adenosarcoma Obstetrics and Gynecology Pediatric gynecologic cancer Pediatrics Uterine cervical neoplasm Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - therapy Uterine Neoplasms - diagnosis Uterine Neoplasms - therapy |
| title | Management of Low Grade Cervical Mullerian Adenosarcoma in a 14-year-old Girl |
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