Functional polymorphism at the miR-502-binding site in the 3′ untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population
MicroRNAs (miRNAs), a class of non-coding RNAs, bind to the 3′ untranslated regions (3′-UTRs) of target mRNAs and regulate gene expression. Genetic variations in miRNA binding domains influence the susceptibility to several diseases such as cancer. Several studies investigated the impact of single-n...
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| Veröffentlicht in: | Gene 2017-08, Vol.626, p.354-357 |
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| creator | Narouie, Behzad Ziaee, Seyed Amir Mohsen Basiri, Abbas Hashemi, Mohammad |
| description | MicroRNAs (miRNAs), a class of non-coding RNAs, bind to the 3′ untranslated regions (3′-UTRs) of target mRNAs and regulate gene expression. Genetic variations in miRNA binding domains influence the susceptibility to several diseases such as cancer. Several studies investigated the impact of single-nucleotide polymorphism (SNP) rs16917496 T>C within the 3′-UTR of SETD8 on cancer susceptibility, but the results were controversial. In addition, no study has been conducted to inspect the impact of this SNP in prostate cancer (PCa). Thus, the present study aimed to find out the possible association between rs16917496 polymorphism at the 3′UTR of SETD8 and PCa risk. This case-control study was done on 169 patients with pathologically confirmed PCa and 182 benign prostatic hyperplasia (BPH). Genotyping was done using PCR-RFLP method. The findings revealed that rs16917496 variant significantly increased the risk of PCa in codominant (OR=2.54, 95%CI=1.50–4.30, p |
| doi_str_mv | 10.1016/j.gene.2017.05.060 |
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•We studied the impact of rs16917496 polymorphism of SETD8 on prostate cancer risk.•Genotyping of SETD8 rs16917496 T>C variant was done by PCR-RFLP method.•We found that rs16917496 variant significantly increased the risk of prostate cancer.•An association between rs16917496 variant and PSA and Gleason score was observed.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2017.05.060</identifier><identifier>PMID: 28578017</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>3' Untranslated Regions ; Adult ; Aged ; Case-Control Studies ; Histone-Lysine N-Methyltransferase - genetics ; Humans ; Iran ; Male ; MicroRNAs - genetics ; Middle Aged ; miRNA-502 ; Polymorphism ; Polymorphism, Single Nucleotide ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; SETD8</subject><ispartof>Gene, 2017-08, Vol.626, p.354-357</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-fed280c2891ff295dedcfd6b08995bab00fd73b498b043bca2d55bcd20f417563</citedby><cites>FETCH-LOGICAL-c422t-fed280c2891ff295dedcfd6b08995bab00fd73b498b043bca2d55bcd20f417563</cites><orcidid>0000-0002-6074-7101</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2017.05.060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28578017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narouie, Behzad</creatorcontrib><creatorcontrib>Ziaee, Seyed Amir Mohsen</creatorcontrib><creatorcontrib>Basiri, Abbas</creatorcontrib><creatorcontrib>Hashemi, Mohammad</creatorcontrib><title>Functional polymorphism at the miR-502-binding site in the 3′ untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population</title><title>Gene</title><addtitle>Gene</addtitle><description>MicroRNAs (miRNAs), a class of non-coding RNAs, bind to the 3′ untranslated regions (3′-UTRs) of target mRNAs and regulate gene expression. Genetic variations in miRNA binding domains influence the susceptibility to several diseases such as cancer. Several studies investigated the impact of single-nucleotide polymorphism (SNP) rs16917496 T>C within the 3′-UTR of SETD8 on cancer susceptibility, but the results were controversial. In addition, no study has been conducted to inspect the impact of this SNP in prostate cancer (PCa). Thus, the present study aimed to find out the possible association between rs16917496 polymorphism at the 3′UTR of SETD8 and PCa risk. This case-control study was done on 169 patients with pathologically confirmed PCa and 182 benign prostatic hyperplasia (BPH). Genotyping was done using PCR-RFLP method. The findings revealed that rs16917496 variant significantly increased the risk of PCa in codominant (OR=2.54, 95%CI=1.50–4.30, p<0.001, TC VS TT and OR=3.03, 95%CI=1.63–5.66, p<0.001, CC vs TT), dominant (OR=2.86, 95%CI=1.62–4.43, p<0.001, p<0.001). The C allele significantly increased the risk of PCa (OR=1.72, 95%CI=1.28–2.33, p<0.001) compared to T allele. In conclusion, the findings indicated that rs16917496 polymorphism may be a risk for predisposition to PCa in an Iranian population. Further studies with larger sample sizes and different ethnicities are required to confirm our findings.
•We studied the impact of rs16917496 polymorphism of SETD8 on prostate cancer risk.•Genotyping of SETD8 rs16917496 T>C variant was done by PCR-RFLP method.•We found that rs16917496 variant significantly increased the risk of prostate cancer.•An association between rs16917496 variant and PSA and Gleason score was observed.</description><subject>3' Untranslated Regions</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Histone-Lysine N-Methyltransferase - genetics</subject><subject>Humans</subject><subject>Iran</subject><subject>Male</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA-502</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>SETD8</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EopfCC7BAXrJJGDtx4khsUH-gUiUkKGvLsSe3viROsB2k7nghNjwST4LTW1jijRfnnE8zcwh5yaBkwJo3h3KPHksOrC1BlNDAI7Jjsu0KgEo-JjuoWlkwxroT8izGA-QnBH9KTrgUrcyxHfl5uXqT3Oz1SJd5vJvmsNy6OFGdaLpFOrlPhQBe9M5b5_c0uoTU-Xut-v3jF119CtrHUSe0NOA-o-g83OufL27OJd1mzAkTUMds2YTg4tfNtIQ5phykRnuDYeNqGvW0jLjJVxnstM9zLWvmZ_Jz8mTQY8QXD_8p-XJ5cXP2obj--P7q7N11YWrOUzGg5RIMlx0bBt4Ji9YMtulBdp3odQ8w2Lbq6072UFe90dwK0RvLYahZK5rqlLw-cvOE31aMSU0uGhxH7XFeo2IdNKzmouLZyo9Wk5eJAQe1BDfpcKcYqK0mdVDbCdRWkwKhck059OqBv_YT2n-Rv71kw9ujAfOW3x0GFY3DfCTrApqk7Oz-x_8DgRWm-w</recordid><startdate>20170830</startdate><enddate>20170830</enddate><creator>Narouie, Behzad</creator><creator>Ziaee, Seyed Amir Mohsen</creator><creator>Basiri, Abbas</creator><creator>Hashemi, Mohammad</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6074-7101</orcidid></search><sort><creationdate>20170830</creationdate><title>Functional polymorphism at the miR-502-binding site in the 3′ untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population</title><author>Narouie, Behzad ; Ziaee, Seyed Amir Mohsen ; Basiri, Abbas ; Hashemi, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-fed280c2891ff295dedcfd6b08995bab00fd73b498b043bca2d55bcd20f417563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>3' Untranslated Regions</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Histone-Lysine N-Methyltransferase - genetics</topic><topic>Humans</topic><topic>Iran</topic><topic>Male</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miRNA-502</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - pathology</topic><topic>SETD8</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Narouie, Behzad</creatorcontrib><creatorcontrib>Ziaee, Seyed Amir Mohsen</creatorcontrib><creatorcontrib>Basiri, Abbas</creatorcontrib><creatorcontrib>Hashemi, Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Narouie, Behzad</au><au>Ziaee, Seyed Amir Mohsen</au><au>Basiri, Abbas</au><au>Hashemi, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional polymorphism at the miR-502-binding site in the 3′ untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2017-08-30</date><risdate>2017</risdate><volume>626</volume><spage>354</spage><epage>357</epage><pages>354-357</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>MicroRNAs (miRNAs), a class of non-coding RNAs, bind to the 3′ untranslated regions (3′-UTRs) of target mRNAs and regulate gene expression. Genetic variations in miRNA binding domains influence the susceptibility to several diseases such as cancer. Several studies investigated the impact of single-nucleotide polymorphism (SNP) rs16917496 T>C within the 3′-UTR of SETD8 on cancer susceptibility, but the results were controversial. In addition, no study has been conducted to inspect the impact of this SNP in prostate cancer (PCa). Thus, the present study aimed to find out the possible association between rs16917496 polymorphism at the 3′UTR of SETD8 and PCa risk. This case-control study was done on 169 patients with pathologically confirmed PCa and 182 benign prostatic hyperplasia (BPH). Genotyping was done using PCR-RFLP method. The findings revealed that rs16917496 variant significantly increased the risk of PCa in codominant (OR=2.54, 95%CI=1.50–4.30, p<0.001, TC VS TT and OR=3.03, 95%CI=1.63–5.66, p<0.001, CC vs TT), dominant (OR=2.86, 95%CI=1.62–4.43, p<0.001, p<0.001). The C allele significantly increased the risk of PCa (OR=1.72, 95%CI=1.28–2.33, p<0.001) compared to T allele. In conclusion, the findings indicated that rs16917496 polymorphism may be a risk for predisposition to PCa in an Iranian population. Further studies with larger sample sizes and different ethnicities are required to confirm our findings.
•We studied the impact of rs16917496 polymorphism of SETD8 on prostate cancer risk.•Genotyping of SETD8 rs16917496 T>C variant was done by PCR-RFLP method.•We found that rs16917496 variant significantly increased the risk of prostate cancer.•An association between rs16917496 variant and PSA and Gleason score was observed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28578017</pmid><doi>10.1016/j.gene.2017.05.060</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6074-7101</orcidid></addata></record> |
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| subjects | 3' Untranslated Regions Adult Aged Case-Control Studies Histone-Lysine N-Methyltransferase - genetics Humans Iran Male MicroRNAs - genetics Middle Aged miRNA-502 Polymorphism Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology SETD8 |
| title | Functional polymorphism at the miR-502-binding site in the 3′ untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population |
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