Hybrid Pharmacophoric Approach in the Design and Synthesis of Coumarin Linked Pyrazolinyl as Urease Inhibitors, Kinetic Mechanism and Molecular Docking

The current research article reports the synthesis of coumarinyl pyrazolinyl thioamide derivatives and their biological activity as inhibitors of jack bean urease. The coumarinyl pyrazolinyl thioamides were synthesized by reacting thiosemicarbazide with newly synthesized chalcones to afford the prod...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry & biodiversity 2017-08, Vol.14 (8), p.n/a
Hauptverfasser:	Saeed, Aamer, Mahesar, Parvez Ali, Channar, Pervaiz Ali, Larik, Fayaz Ali, Abbas, Qamar, Hassan, Mubashir, Raza, Hussain, Seo, Sung‐Yum
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antioxidant activities Antioxidants - chemistry Binding Binding Sites Biological activity Chemical synthesis Coumarin Coumarins - chemistry Coumarinyl pyrazolinyl thioamides Derivatives Drug Design Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzymes Fabaceae - enzymology Half-Life Helicobacter - drug effects Hybrid pharmacophore Inhibition Inhibitors Jack bean urease inhibitors Jack beans Kinetics Molecular docking Molecular Docking Simulation Pharmacology Protein Structure, Tertiary Pyrazole Pyrazoles - chemistry Recrystallization Structure-Activity Relationship Synthesis Thermodynamics Thiourea Urease Urease - antagonists & inhibitors Urease - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!