The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis
Abstract Objective To investigate the effects of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. Materials and Methods Thirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n=10), alcohol (n=10), control (n=8) and normal (n=4) groups. All tympanic membranes except normal...
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| Veröffentlicht in: | International journal of pediatric otorhinolaryngology 2017-04, Vol.95, p.127-132 |
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| creator | Ağrı, İbrahim, MD Erdal Ağrı, Arzu, MD Sancaktar, Mehmet Eser, MD Ünal, Asude, MD Can, Erkan, MD Bakırtaş, Mustafa, MD Yılmaz, Fatih, MD Demirağ, Mehmet Derya, MD Ünal, Recep, MD |
| description | Abstract Objective To investigate the effects of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. Materials and Methods Thirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n=10), alcohol (n=10), control (n=8) and normal (n=4) groups. All tympanic membranes except normal group were myringotomised and type 3 Streptococcus pneumoniae strains was injected into their middle ears. Myringotomies were repeated for 5 weeks. Intraperitoneal (i.p) CAPE were administrated to the CAPE group at 10 μmol/kg/day and 10% ethyl alcohol administrated to the alcohol group for 5 weeks. The control group were left untreated. Findings of myringosclerosis were recorded by otomicroscope at sixth week. Then, all rats were sacrificed and tympanic membrane thickness and severity of middle ear mucosal inflammation evaluated histopathalogically. Results Severity of myringosclerosis was significantly higher in the alcohol and control groups compared to the CAPE group (p |
| doi_str_mv | 10.1016/j.ijporl.2017.02.020 |
| format | Article |
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Materials and Methods Thirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n=10), alcohol (n=10), control (n=8) and normal (n=4) groups. All tympanic membranes except normal group were myringotomised and type 3 Streptococcus pneumoniae strains was injected into their middle ears. Myringotomies were repeated for 5 weeks. Intraperitoneal (i.p) CAPE were administrated to the CAPE group at 10 μmol/kg/day and 10% ethyl alcohol administrated to the alcohol group for 5 weeks. The control group were left untreated. Findings of myringosclerosis were recorded by otomicroscope at sixth week. Then, all rats were sacrificed and tympanic membrane thickness and severity of middle ear mucosal inflammation evaluated histopathalogically. Results Severity of myringosclerosis was significantly higher in the alcohol and control groups compared to the CAPE group (p<0.001), but was not significant when alcohol and control groups were compared (p=0.17). The tympanic membrane thickness measured in the alcohol and control groups were significantly higher compared to the CAPE group (p<0.001), but was not significant when alcohol and control groups were compared (p=0.17). The severity of inflammation in the middle ear mucosa was significantly higher in the alcohol and control groups compared to the CAPE group (respectively, p<0.001, p=0.03). The severity of inflammation in the middle ear mucosa was not significant between alcohol and control groups (p=0.30). Conclusion CAPE has anti-inflammatory and antioxidant effects on the development of MS in myringotomized rats, so reduces the severity of tympanosclerosis.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/j.ijporl.2017.02.020</identifier><identifier>PMID: 28576521</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - pharmacology ; Caffeic Acids - pharmacology ; CAPE ; Inflammation - drug therapy ; Male ; Middle Ear Ventilation ; Myringosclerosis - drug therapy ; Otolaryngology ; Pediatrics ; Phenylethyl Alcohol - analogs & derivatives ; Phenylethyl Alcohol - pharmacology ; Rats ; Rats, Sprague-Dawley ; Tympanic membrane ; Tympanic Membrane - drug effects ; Tympanic Membrane - pathology ; Tympanosclerosis</subject><ispartof>International journal of pediatric otorhinolaryngology, 2017-04, Vol.95, p.127-132</ispartof><rights>Elsevier B.V.</rights><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-640de03506979bf4b4516607a9bcbb27a0c218e3a4aeef9a9be39c658d5d92f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijporl.2017.02.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28576521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ağrı, İbrahim, MD</creatorcontrib><creatorcontrib>Erdal Ağrı, Arzu, MD</creatorcontrib><creatorcontrib>Sancaktar, Mehmet Eser, MD</creatorcontrib><creatorcontrib>Ünal, Asude, MD</creatorcontrib><creatorcontrib>Can, Erkan, MD</creatorcontrib><creatorcontrib>Bakırtaş, Mustafa, MD</creatorcontrib><creatorcontrib>Yılmaz, Fatih, MD</creatorcontrib><creatorcontrib>Demirağ, Mehmet Derya, MD</creatorcontrib><creatorcontrib>Ünal, Recep, MD</creatorcontrib><title>The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis</title><title>International journal of pediatric otorhinolaryngology</title><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><description>Abstract Objective To investigate the effects of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. Materials and Methods Thirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n=10), alcohol (n=10), control (n=8) and normal (n=4) groups. All tympanic membranes except normal group were myringotomised and type 3 Streptococcus pneumoniae strains was injected into their middle ears. Myringotomies were repeated for 5 weeks. Intraperitoneal (i.p) CAPE were administrated to the CAPE group at 10 μmol/kg/day and 10% ethyl alcohol administrated to the alcohol group for 5 weeks. The control group were left untreated. Findings of myringosclerosis were recorded by otomicroscope at sixth week. Then, all rats were sacrificed and tympanic membrane thickness and severity of middle ear mucosal inflammation evaluated histopathalogically. Results Severity of myringosclerosis was significantly higher in the alcohol and control groups compared to the CAPE group (p<0.001), but was not significant when alcohol and control groups were compared (p=0.17). The tympanic membrane thickness measured in the alcohol and control groups were significantly higher compared to the CAPE group (p<0.001), but was not significant when alcohol and control groups were compared (p=0.17). The severity of inflammation in the middle ear mucosa was significantly higher in the alcohol and control groups compared to the CAPE group (respectively, p<0.001, p=0.03). The severity of inflammation in the middle ear mucosa was not significant between alcohol and control groups (p=0.30). Conclusion CAPE has anti-inflammatory and antioxidant effects on the development of MS in myringotomized rats, so reduces the severity of tympanosclerosis.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Caffeic Acids - pharmacology</subject><subject>CAPE</subject><subject>Inflammation - drug therapy</subject><subject>Male</subject><subject>Middle Ear Ventilation</subject><subject>Myringosclerosis - drug therapy</subject><subject>Otolaryngology</subject><subject>Pediatrics</subject><subject>Phenylethyl Alcohol - analogs & derivatives</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tympanic membrane</subject><subject>Tympanic Membrane - drug effects</subject><subject>Tympanic Membrane - pathology</subject><subject>Tympanosclerosis</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAQgEVpSbZp_kEpOiYHb0eS9fClEJZNUwi00PQsZHnMyvVaruQt7L-vlk176CUwICG-eegbQt4zWDNg6uOwDsMc07jmwPQaeAl4RVbMaF6ZWtWvyapgspJGq0vyNucBCghSXpBLbqRWkrMV2T7tkGLfo19o7Kl35Ro8dT50dN7hhMvuOFLMCyZ6s7n7tr2lcaLLcT-7KWY_Yoo55HfkTe_GjNfP5xX5cb992jxUj18_f9ncPVZeKLVUqoYOQUhQjW7avm5ryZQC7ZrWty3XDjxnBoWrHWLflGcUjVfSdLJreF-LK3Jzrjun-OtQprL7kD2Oo5swHrJlDUgtjBGyoPUZ9WXCnLC3cwp7l46WgT0JtIM9C7QngRZ4CShpH547HNo9dv-S_horwKczgOWfvwMmm33AyWMXUpFouxhe6vB_AT-GKXg3_sQj5iEe0lQcWmZzSbDfT0s87ZBpAWAAxB-HCpc_</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Ağrı, İbrahim, MD</creator><creator>Erdal Ağrı, Arzu, MD</creator><creator>Sancaktar, Mehmet Eser, MD</creator><creator>Ünal, Asude, MD</creator><creator>Can, Erkan, MD</creator><creator>Bakırtaş, Mustafa, MD</creator><creator>Yılmaz, Fatih, MD</creator><creator>Demirağ, Mehmet Derya, MD</creator><creator>Ünal, Recep, MD</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis</title><author>Ağrı, İbrahim, MD ; Erdal Ağrı, Arzu, MD ; Sancaktar, Mehmet Eser, MD ; Ünal, Asude, MD ; Can, Erkan, MD ; Bakırtaş, Mustafa, MD ; Yılmaz, Fatih, MD ; Demirağ, Mehmet Derya, MD ; Ünal, Recep, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-640de03506979bf4b4516607a9bcbb27a0c218e3a4aeef9a9be39c658d5d92f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Caffeic Acids - pharmacology</topic><topic>CAPE</topic><topic>Inflammation - drug therapy</topic><topic>Male</topic><topic>Middle Ear Ventilation</topic><topic>Myringosclerosis - drug therapy</topic><topic>Otolaryngology</topic><topic>Pediatrics</topic><topic>Phenylethyl Alcohol - analogs & derivatives</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tympanic membrane</topic><topic>Tympanic Membrane - drug effects</topic><topic>Tympanic Membrane - pathology</topic><topic>Tympanosclerosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ağrı, İbrahim, MD</creatorcontrib><creatorcontrib>Erdal Ağrı, Arzu, MD</creatorcontrib><creatorcontrib>Sancaktar, Mehmet Eser, MD</creatorcontrib><creatorcontrib>Ünal, Asude, MD</creatorcontrib><creatorcontrib>Can, Erkan, MD</creatorcontrib><creatorcontrib>Bakırtaş, Mustafa, MD</creatorcontrib><creatorcontrib>Yılmaz, Fatih, MD</creatorcontrib><creatorcontrib>Demirağ, Mehmet Derya, MD</creatorcontrib><creatorcontrib>Ünal, Recep, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ağrı, İbrahim, MD</au><au>Erdal Ağrı, Arzu, MD</au><au>Sancaktar, Mehmet Eser, MD</au><au>Ünal, Asude, MD</au><au>Can, Erkan, MD</au><au>Bakırtaş, Mustafa, MD</au><au>Yılmaz, Fatih, MD</au><au>Demirağ, Mehmet Derya, MD</au><au>Ünal, Recep, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>95</volume><spage>127</spage><epage>132</epage><pages>127-132</pages><issn>0165-5876</issn><eissn>1872-8464</eissn><abstract>Abstract Objective To investigate the effects of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. Materials and Methods Thirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n=10), alcohol (n=10), control (n=8) and normal (n=4) groups. All tympanic membranes except normal group were myringotomised and type 3 Streptococcus pneumoniae strains was injected into their middle ears. Myringotomies were repeated for 5 weeks. Intraperitoneal (i.p) CAPE were administrated to the CAPE group at 10 μmol/kg/day and 10% ethyl alcohol administrated to the alcohol group for 5 weeks. The control group were left untreated. Findings of myringosclerosis were recorded by otomicroscope at sixth week. Then, all rats were sacrificed and tympanic membrane thickness and severity of middle ear mucosal inflammation evaluated histopathalogically. Results Severity of myringosclerosis was significantly higher in the alcohol and control groups compared to the CAPE group (p<0.001), but was not significant when alcohol and control groups were compared (p=0.17). The tympanic membrane thickness measured in the alcohol and control groups were significantly higher compared to the CAPE group (p<0.001), but was not significant when alcohol and control groups were compared (p=0.17). The severity of inflammation in the middle ear mucosa was significantly higher in the alcohol and control groups compared to the CAPE group (respectively, p<0.001, p=0.03). The severity of inflammation in the middle ear mucosa was not significant between alcohol and control groups (p=0.30). Conclusion CAPE has anti-inflammatory and antioxidant effects on the development of MS in myringotomized rats, so reduces the severity of tympanosclerosis.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28576521</pmid><doi>10.1016/j.ijporl.2017.02.020</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Caffeic Acids - pharmacology CAPE Inflammation - drug therapy Male Middle Ear Ventilation Myringosclerosis - drug therapy Otolaryngology Pediatrics Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Rats Rats, Sprague-Dawley Tympanic membrane Tympanic Membrane - drug effects Tympanic Membrane - pathology Tympanosclerosis |
| title | The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis |
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