Role of Heat Shock Factor 1 in Conserving Cholesterol Transportation in Leydig Cell Steroidogenesis via Steroidogenic Acute Regulatory Protein

Abstract Testicular testosterone synthesis begins with cholesterol transport into mitochondria via steroidogenic acute regulatory (StAR) protein in Leydig cells. Acute heat stress is known to obstruct testicular steroidogenesis by transcriptional repression of StAR. In contrast, chronic heat stress...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2017-08, Vol.158 (8), p.2648-2658
Hauptverfasser:	Oka, Shintaro, Shiraishi, Koji, Fujimoto, Mitsuaki, Katiyar, Arpit, Takii, Ryosuke, Nakai, Akira, Matsuyama, Hideyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Cholesterol Cholesterol - metabolism Cryptorchidism Cytosol DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endocrinology Enzymes Epithelium Gene Expression Regulation - physiology Gene silencing Heat shock factors Heat shock proteins Heat Shock Transcription Factors Heat stress Heat tolerance Hot Temperature HSF1 protein Leydig cells Leydig Cells - metabolism Lipids Male Mice Mice, Knockout Mitochondria mRNA Protein biosynthesis Protein deficiency Protein transport Proteins Ribonucleic acid RNA RNA modification Steroidogenesis Steroidogenic acute regulatory protein Steroids Stress response Stress, Physiological Synthesis Temperature effects Testes Testosterone Testosterone - biosynthesis Transcription Factors - genetics Transcription Factors - metabolism Transportation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!