Hypothalamic Inflammation in Human Obesity Is Mediated by Environmental and Genetic Factors

Obesity is associated with hypothalamic inflammation (HI) in animal models. In the current study, we examined the mediobasal hypothalamus (MBH) of 57 obese human subjects and 54 age- and sex- matched nonobese control subjects by MRI and analyzed the T2 hyperintensity as a measure of HI. Obese subjec...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2017-09, Vol.66 (9), p.2407-2415
Hauptverfasser:	Kreutzer, Carina, Peters, Sönke, Schulte, Dominik M, Fangmann, Daniela, Türk, Kathrin, Wolff, Stephan, van Eimeren, Thilo, Ahrens, Markus, Beckmann, Jan, Schafmayer, Clemens, Becker, Thomas, Kerby, Tina, Rohr, Axel, Riedel, Christian, Heinsen, Femke-Anouska, Degenhardt, Frauke, Franke, Andre, Rosenstiel, Philip, Zubek, Nana, Henning, Christian, Freitag-Wolf, Sandra, Dempfle, Astrid, Psilopanagioti, Aristea, Petrou-Papadaki, Helen, Lenk, Lennart, Jansen, Olav, Schreiber, Stefan, Laudes, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animal models Bacteria - classification Biomarkers Body weight loss Case-Control Studies Clinical trials Environmental factors Epigenesis, Genetic - physiology Female Gastrointestinal Tract - microbiology Genetic factors Genetics High fat diet Human subjects Humans Hypertriglyceridemia Hypothalamus Hypothalamus - diagnostic imaging Hypothalamus - physiology Inflammation Inflammation - genetics Inflammation - metabolism Insulin Insulin Resistance JNK protein Magnetic Resonance Imaging Male Middle Aged Obesity Obesity - etiology Obesity - metabolism RNA, Ribosomal, 16S - genetics RNA, Ribosomal, 16S - metabolism rRNA 16S Structure-function relationships Surgery
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