Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial
Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists ag...
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| Veröffentlicht in: | Journal of tropical pediatrics (1980) 2018-04, Vol.64 (2), p.110-117 |
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| container_title | Journal of tropical pediatrics (1980) |
| container_volume | 64 |
| creator | Bagri, Narendra Kumar Bagri, Neha Jana, Manisha Gupta, Arun Kumar Wadhwa, Nitya Lodha, Rakesh Kabra, Sushil Kumar Chandran, Aruna Aneja, Satinder Chaturvedi, Mona K Sodhi, Jitender Fitzwater, Sean Patrick Chandra, Jagdish Rath, Bimbadhar Kainth, Udaypal S Saini, Savita Black, Robert E Santosham, Mathuram Bhatnagar, Shinjini |
| description | Abstract
Objective
To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age.
Patients and Methods
We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model.
Results
Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation.
Conclusion
There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia. |
| doi_str_mv | 10.1093/tropej/fmx036 |
| format | Article |
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Objective
To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age.
Patients and Methods
We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model.
Results
Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation.
Conclusion
There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmx036</identifier><identifier>PMID: 28575379</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Journal of tropical pediatrics (1980), 2018-04, Vol.64 (2), p.110-117</ispartof><rights>The Author [2017]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-d88f7afd2118a275cd314c0a8200be18b4ee3fbac89264f052573879d344f3d13</citedby><cites>FETCH-LOGICAL-c365t-d88f7afd2118a275cd314c0a8200be18b4ee3fbac89264f052573879d344f3d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28575379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bagri, Narendra Kumar</creatorcontrib><creatorcontrib>Bagri, Neha</creatorcontrib><creatorcontrib>Jana, Manisha</creatorcontrib><creatorcontrib>Gupta, Arun Kumar</creatorcontrib><creatorcontrib>Wadhwa, Nitya</creatorcontrib><creatorcontrib>Lodha, Rakesh</creatorcontrib><creatorcontrib>Kabra, Sushil Kumar</creatorcontrib><creatorcontrib>Chandran, Aruna</creatorcontrib><creatorcontrib>Aneja, Satinder</creatorcontrib><creatorcontrib>Chaturvedi, Mona K</creatorcontrib><creatorcontrib>Sodhi, Jitender</creatorcontrib><creatorcontrib>Fitzwater, Sean Patrick</creatorcontrib><creatorcontrib>Chandra, Jagdish</creatorcontrib><creatorcontrib>Rath, Bimbadhar</creatorcontrib><creatorcontrib>Kainth, Udaypal S</creatorcontrib><creatorcontrib>Saini, Savita</creatorcontrib><creatorcontrib>Black, Robert E</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><creatorcontrib>Bhatnagar, Shinjini</creatorcontrib><title>Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>Abstract
Objective
To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age.
Patients and Methods
We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model.
Results
Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation.
Conclusion
There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.</description><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkDtPwzAURi0EglIYWZFHllA7dhKHrarKQ6pUxGNhiVw_kJFjBzuRKBM_HVctMDL5Duf7ru8B4AyjS4xqMumD79TbRLcfiJR7YIRpWWSkLOk-GCFM86wkhB2B4xjfEEI5o_QQHOWsqApS1SPwNdfaCC7W0Gu4DNzCF-MEfBy6zqpWuZ73xjtoHHzg0njrXxNt7RrOvNMmtErCe6eG1jvDr-CjEt5JHtZw6rhdRxM3tTxlnfSt-Ux0yqUvW5vGp2C4PQEHmtuoTnfvGDxfz59mt9lieXM3my4yQcqizyRjuuJa5hgznleFkARTgTjLEVopzFZUKaJXXLA6L6lGRV5UhFW1JJRqIjEZg4ttbxf8-6Bi37QmCmUtd8oPscE1SglS1FVCsy0qgo8xKN10wbTpqgajZiO92UpvttITf76rHlZJyC_9Y_lvtx-6f7q-AfxRj2Q</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Bagri, Narendra Kumar</creator><creator>Bagri, Neha</creator><creator>Jana, Manisha</creator><creator>Gupta, Arun Kumar</creator><creator>Wadhwa, Nitya</creator><creator>Lodha, Rakesh</creator><creator>Kabra, Sushil Kumar</creator><creator>Chandran, Aruna</creator><creator>Aneja, Satinder</creator><creator>Chaturvedi, Mona K</creator><creator>Sodhi, Jitender</creator><creator>Fitzwater, Sean Patrick</creator><creator>Chandra, Jagdish</creator><creator>Rath, Bimbadhar</creator><creator>Kainth, Udaypal S</creator><creator>Saini, Savita</creator><creator>Black, Robert E</creator><creator>Santosham, Mathuram</creator><creator>Bhatnagar, Shinjini</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial</title><author>Bagri, Narendra Kumar ; Bagri, Neha ; Jana, Manisha ; Gupta, Arun Kumar ; Wadhwa, Nitya ; Lodha, Rakesh ; Kabra, Sushil Kumar ; Chandran, Aruna ; Aneja, Satinder ; Chaturvedi, Mona K ; Sodhi, Jitender ; Fitzwater, Sean Patrick ; Chandra, Jagdish ; Rath, Bimbadhar ; Kainth, Udaypal S ; Saini, Savita ; Black, Robert E ; Santosham, Mathuram ; Bhatnagar, Shinjini</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-d88f7afd2118a275cd314c0a8200be18b4ee3fbac89264f052573879d344f3d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagri, Narendra Kumar</creatorcontrib><creatorcontrib>Bagri, Neha</creatorcontrib><creatorcontrib>Jana, Manisha</creatorcontrib><creatorcontrib>Gupta, Arun Kumar</creatorcontrib><creatorcontrib>Wadhwa, Nitya</creatorcontrib><creatorcontrib>Lodha, Rakesh</creatorcontrib><creatorcontrib>Kabra, Sushil Kumar</creatorcontrib><creatorcontrib>Chandran, Aruna</creatorcontrib><creatorcontrib>Aneja, Satinder</creatorcontrib><creatorcontrib>Chaturvedi, Mona K</creatorcontrib><creatorcontrib>Sodhi, Jitender</creatorcontrib><creatorcontrib>Fitzwater, Sean Patrick</creatorcontrib><creatorcontrib>Chandra, Jagdish</creatorcontrib><creatorcontrib>Rath, Bimbadhar</creatorcontrib><creatorcontrib>Kainth, Udaypal S</creatorcontrib><creatorcontrib>Saini, Savita</creatorcontrib><creatorcontrib>Black, Robert E</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><creatorcontrib>Bhatnagar, Shinjini</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagri, Narendra Kumar</au><au>Bagri, Neha</au><au>Jana, Manisha</au><au>Gupta, Arun Kumar</au><au>Wadhwa, Nitya</au><au>Lodha, Rakesh</au><au>Kabra, Sushil Kumar</au><au>Chandran, Aruna</au><au>Aneja, Satinder</au><au>Chaturvedi, Mona K</au><au>Sodhi, Jitender</au><au>Fitzwater, Sean Patrick</au><au>Chandra, Jagdish</au><au>Rath, Bimbadhar</au><au>Kainth, Udaypal S</au><au>Saini, Savita</au><au>Black, Robert E</au><au>Santosham, Mathuram</au><au>Bhatnagar, Shinjini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>64</volume><issue>2</issue><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><abstract>Abstract
Objective
To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age.
Patients and Methods
We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model.
Results
Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation.
Conclusion
There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28575379</pmid><doi>10.1093/tropej/fmx036</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial |
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