Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial

Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists ag...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of tropical pediatrics (1980) 2018-04, Vol.64 (2), p.110-117
Hauptverfasser: Bagri, Narendra Kumar, Bagri, Neha, Jana, Manisha, Gupta, Arun Kumar, Wadhwa, Nitya, Lodha, Rakesh, Kabra, Sushil Kumar, Chandran, Aruna, Aneja, Satinder, Chaturvedi, Mona K, Sodhi, Jitender, Fitzwater, Sean Patrick, Chandra, Jagdish, Rath, Bimbadhar, Kainth, Udaypal S, Saini, Savita, Black, Robert E, Santosham, Mathuram, Bhatnagar, Shinjini
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 117
container_issue 2
container_start_page 110
container_title Journal of tropical pediatrics (1980)
container_volume 64
creator Bagri, Narendra Kumar
Bagri, Neha
Jana, Manisha
Gupta, Arun Kumar
Wadhwa, Nitya
Lodha, Rakesh
Kabra, Sushil Kumar
Chandran, Aruna
Aneja, Satinder
Chaturvedi, Mona K
Sodhi, Jitender
Fitzwater, Sean Patrick
Chandra, Jagdish
Rath, Bimbadhar
Kainth, Udaypal S
Saini, Savita
Black, Robert E
Santosham, Mathuram
Bhatnagar, Shinjini
description Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation. Conclusion There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.
doi_str_mv 10.1093/tropej/fmx036
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1905733597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/tropej/fmx036</oup_id><sourcerecordid>1905733597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-d88f7afd2118a275cd314c0a8200be18b4ee3fbac89264f052573879d344f3d13</originalsourceid><addsrcrecordid>eNqFkDtPwzAURi0EglIYWZFHllA7dhKHrarKQ6pUxGNhiVw_kJFjBzuRKBM_HVctMDL5Duf7ru8B4AyjS4xqMumD79TbRLcfiJR7YIRpWWSkLOk-GCFM86wkhB2B4xjfEEI5o_QQHOWsqApS1SPwNdfaCC7W0Gu4DNzCF-MEfBy6zqpWuZ73xjtoHHzg0njrXxNt7RrOvNMmtErCe6eG1jvDr-CjEt5JHtZw6rhdRxM3tTxlnfSt-Ux0yqUvW5vGp2C4PQEHmtuoTnfvGDxfz59mt9lieXM3my4yQcqizyRjuuJa5hgznleFkARTgTjLEVopzFZUKaJXXLA6L6lGRV5UhFW1JJRqIjEZg4ttbxf8-6Bi37QmCmUtd8oPscE1SglS1FVCsy0qgo8xKN10wbTpqgajZiO92UpvttITf76rHlZJyC_9Y_lvtx-6f7q-AfxRj2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1905733597</pqid></control><display><type>article</type><title>Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Bagri, Narendra Kumar ; Bagri, Neha ; Jana, Manisha ; Gupta, Arun Kumar ; Wadhwa, Nitya ; Lodha, Rakesh ; Kabra, Sushil Kumar ; Chandran, Aruna ; Aneja, Satinder ; Chaturvedi, Mona K ; Sodhi, Jitender ; Fitzwater, Sean Patrick ; Chandra, Jagdish ; Rath, Bimbadhar ; Kainth, Udaypal S ; Saini, Savita ; Black, Robert E ; Santosham, Mathuram ; Bhatnagar, Shinjini</creator><creatorcontrib>Bagri, Narendra Kumar ; Bagri, Neha ; Jana, Manisha ; Gupta, Arun Kumar ; Wadhwa, Nitya ; Lodha, Rakesh ; Kabra, Sushil Kumar ; Chandran, Aruna ; Aneja, Satinder ; Chaturvedi, Mona K ; Sodhi, Jitender ; Fitzwater, Sean Patrick ; Chandra, Jagdish ; Rath, Bimbadhar ; Kainth, Udaypal S ; Saini, Savita ; Black, Robert E ; Santosham, Mathuram ; Bhatnagar, Shinjini</creatorcontrib><description>Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation. Conclusion There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmx036</identifier><identifier>PMID: 28575379</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Journal of tropical pediatrics (1980), 2018-04, Vol.64 (2), p.110-117</ispartof><rights>The Author [2017]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-d88f7afd2118a275cd314c0a8200be18b4ee3fbac89264f052573879d344f3d13</citedby><cites>FETCH-LOGICAL-c365t-d88f7afd2118a275cd314c0a8200be18b4ee3fbac89264f052573879d344f3d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28575379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bagri, Narendra Kumar</creatorcontrib><creatorcontrib>Bagri, Neha</creatorcontrib><creatorcontrib>Jana, Manisha</creatorcontrib><creatorcontrib>Gupta, Arun Kumar</creatorcontrib><creatorcontrib>Wadhwa, Nitya</creatorcontrib><creatorcontrib>Lodha, Rakesh</creatorcontrib><creatorcontrib>Kabra, Sushil Kumar</creatorcontrib><creatorcontrib>Chandran, Aruna</creatorcontrib><creatorcontrib>Aneja, Satinder</creatorcontrib><creatorcontrib>Chaturvedi, Mona K</creatorcontrib><creatorcontrib>Sodhi, Jitender</creatorcontrib><creatorcontrib>Fitzwater, Sean Patrick</creatorcontrib><creatorcontrib>Chandra, Jagdish</creatorcontrib><creatorcontrib>Rath, Bimbadhar</creatorcontrib><creatorcontrib>Kainth, Udaypal S</creatorcontrib><creatorcontrib>Saini, Savita</creatorcontrib><creatorcontrib>Black, Robert E</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><creatorcontrib>Bhatnagar, Shinjini</creatorcontrib><title>Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation. Conclusion There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.</description><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkDtPwzAURi0EglIYWZFHllA7dhKHrarKQ6pUxGNhiVw_kJFjBzuRKBM_HVctMDL5Duf7ru8B4AyjS4xqMumD79TbRLcfiJR7YIRpWWSkLOk-GCFM86wkhB2B4xjfEEI5o_QQHOWsqApS1SPwNdfaCC7W0Gu4DNzCF-MEfBy6zqpWuZ73xjtoHHzg0njrXxNt7RrOvNMmtErCe6eG1jvDr-CjEt5JHtZw6rhdRxM3tTxlnfSt-Ux0yqUvW5vGp2C4PQEHmtuoTnfvGDxfz59mt9lieXM3my4yQcqizyRjuuJa5hgznleFkARTgTjLEVopzFZUKaJXXLA6L6lGRV5UhFW1JJRqIjEZg4ttbxf8-6Bi37QmCmUtd8oPscE1SglS1FVCsy0qgo8xKN10wbTpqgajZiO92UpvttITf76rHlZJyC_9Y_lvtx-6f7q-AfxRj2Q</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Bagri, Narendra Kumar</creator><creator>Bagri, Neha</creator><creator>Jana, Manisha</creator><creator>Gupta, Arun Kumar</creator><creator>Wadhwa, Nitya</creator><creator>Lodha, Rakesh</creator><creator>Kabra, Sushil Kumar</creator><creator>Chandran, Aruna</creator><creator>Aneja, Satinder</creator><creator>Chaturvedi, Mona K</creator><creator>Sodhi, Jitender</creator><creator>Fitzwater, Sean Patrick</creator><creator>Chandra, Jagdish</creator><creator>Rath, Bimbadhar</creator><creator>Kainth, Udaypal S</creator><creator>Saini, Savita</creator><creator>Black, Robert E</creator><creator>Santosham, Mathuram</creator><creator>Bhatnagar, Shinjini</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial</title><author>Bagri, Narendra Kumar ; Bagri, Neha ; Jana, Manisha ; Gupta, Arun Kumar ; Wadhwa, Nitya ; Lodha, Rakesh ; Kabra, Sushil Kumar ; Chandran, Aruna ; Aneja, Satinder ; Chaturvedi, Mona K ; Sodhi, Jitender ; Fitzwater, Sean Patrick ; Chandra, Jagdish ; Rath, Bimbadhar ; Kainth, Udaypal S ; Saini, Savita ; Black, Robert E ; Santosham, Mathuram ; Bhatnagar, Shinjini</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-d88f7afd2118a275cd314c0a8200be18b4ee3fbac89264f052573879d344f3d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagri, Narendra Kumar</creatorcontrib><creatorcontrib>Bagri, Neha</creatorcontrib><creatorcontrib>Jana, Manisha</creatorcontrib><creatorcontrib>Gupta, Arun Kumar</creatorcontrib><creatorcontrib>Wadhwa, Nitya</creatorcontrib><creatorcontrib>Lodha, Rakesh</creatorcontrib><creatorcontrib>Kabra, Sushil Kumar</creatorcontrib><creatorcontrib>Chandran, Aruna</creatorcontrib><creatorcontrib>Aneja, Satinder</creatorcontrib><creatorcontrib>Chaturvedi, Mona K</creatorcontrib><creatorcontrib>Sodhi, Jitender</creatorcontrib><creatorcontrib>Fitzwater, Sean Patrick</creatorcontrib><creatorcontrib>Chandra, Jagdish</creatorcontrib><creatorcontrib>Rath, Bimbadhar</creatorcontrib><creatorcontrib>Kainth, Udaypal S</creatorcontrib><creatorcontrib>Saini, Savita</creatorcontrib><creatorcontrib>Black, Robert E</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><creatorcontrib>Bhatnagar, Shinjini</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagri, Narendra Kumar</au><au>Bagri, Neha</au><au>Jana, Manisha</au><au>Gupta, Arun Kumar</au><au>Wadhwa, Nitya</au><au>Lodha, Rakesh</au><au>Kabra, Sushil Kumar</au><au>Chandran, Aruna</au><au>Aneja, Satinder</au><au>Chaturvedi, Mona K</au><au>Sodhi, Jitender</au><au>Fitzwater, Sean Patrick</au><au>Chandra, Jagdish</au><au>Rath, Bimbadhar</au><au>Kainth, Udaypal S</au><au>Saini, Savita</au><au>Black, Robert E</au><au>Santosham, Mathuram</au><au>Bhatnagar, Shinjini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>64</volume><issue>2</issue><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><abstract>Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation. Conclusion There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28575379</pmid><doi>10.1093/tropej/fmx036</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0142-6338
ispartof Journal of tropical pediatrics (1980), 2018-04, Vol.64 (2), p.110-117
issn 0142-6338
1465-3664
language eng
recordid cdi_proquest_miscellaneous_1905733597
source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
title Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T00%3A50%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20of%20Oral%20Zinc%20Supplementation%20in%20Radiologically%20Confirmed%20Pneumonia:%20Secondary%20Analysis%20of%20a%20Randomized%20Controlled%20Trial&rft.jtitle=Journal%20of%20tropical%20pediatrics%20(1980)&rft.au=Bagri,%20Narendra%20Kumar&rft.date=2018-04-01&rft.volume=64&rft.issue=2&rft.spage=110&rft.epage=117&rft.pages=110-117&rft.issn=0142-6338&rft.eissn=1465-3664&rft_id=info:doi/10.1093/tropej/fmx036&rft_dat=%3Cproquest_cross%3E1905733597%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1905733597&rft_id=info:pmid/28575379&rft_oup_id=10.1093/tropej/fmx036&rfr_iscdi=true