Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial

Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists ag...

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Veröffentlicht in:Journal of tropical pediatrics (1980) 2018-04, Vol.64 (2), p.110-117
Hauptverfasser: Bagri, Narendra Kumar, Bagri, Neha, Jana, Manisha, Gupta, Arun Kumar, Wadhwa, Nitya, Lodha, Rakesh, Kabra, Sushil Kumar, Chandran, Aruna, Aneja, Satinder, Chaturvedi, Mona K, Sodhi, Jitender, Fitzwater, Sean Patrick, Chandra, Jagdish, Rath, Bimbadhar, Kainth, Udaypal S, Saini, Savita, Black, Robert E, Santosham, Mathuram, Bhatnagar, Shinjini
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container_end_page 117
container_issue 2
container_start_page 110
container_title Journal of tropical pediatrics (1980)
container_volume 64
creator Bagri, Narendra Kumar
Bagri, Neha
Jana, Manisha
Gupta, Arun Kumar
Wadhwa, Nitya
Lodha, Rakesh
Kabra, Sushil Kumar
Chandran, Aruna
Aneja, Satinder
Chaturvedi, Mona K
Sodhi, Jitender
Fitzwater, Sean Patrick
Chandra, Jagdish
Rath, Bimbadhar
Kainth, Udaypal S
Saini, Savita
Black, Robert E
Santosham, Mathuram
Bhatnagar, Shinjini
description Abstract Objective To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2–24 months of age. Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation. Conclusion There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.
doi_str_mv 10.1093/tropej/fmx036
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Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation. Conclusion There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmx036</identifier><identifier>PMID: 28575379</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Journal of tropical pediatrics (1980), 2018-04, Vol.64 (2), p.110-117</ispartof><rights>The Author [2017]. Published by Oxford University Press. All rights reserved. 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Patients and Methods We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n = 121, zinc group and n = 91, placebo group) using a Cox proportional hazards regression model. Results Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: −4.8, 15.1) with zinc supplementation. 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source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
title Efficacy of Oral Zinc Supplementation in Radiologically Confirmed Pneumonia: Secondary Analysis of a Randomized Controlled Trial
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