Bioactivity-guided mixed synthesis accelerate the serendipity in lead optimization: Discovery of fungicidal homodrimanyl amides

The bioactivity-guided mixed synthesis was conceived, in which the designed mix-reactions were run in parallel for simultaneous construction of different kinds of analogs. The valuable ones were protruded by biological screening. This tactic will facilitate more rapid incorporation of bioactive cand...

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Veröffentlicht in:	European journal of medicinal chemistry 2017-08, Vol.136, p.114-121
Hauptverfasser:	Li, Dangdang, Zhang, Shasha, Song, Zehua, Wang, Guotong, Li, Shengkun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - chemistry Amides - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Ascomycota - drug effects Botrytis - drug effects Chiral pesticide Dose-Response Relationship, Drug Drug Discovery Fungicides, Industrial - chemical synthesis Fungicides, Industrial - chemistry Fungicides, Industrial - pharmacology Lead optimization Microbial Sensitivity Tests Mixed synthesis Molecular Structure Natural products Structure-Activity Relationship
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