Evolution and dissemination of the Klebsiella pneumoniae clonal group 258 throughout Israeli post-acute care hospitals, 2008-13
The KPC-producing Klebsiella pneumoniae (KPC-KP) clonal group (CG) 258 has disseminated throughout Israeli post-acute care hospitals (PACHs). The objectives of the study were (i) to describe the evolution and (ii) to understand the dissemination modes of CG 258 in the PACH system in Israel. KPC-KP s...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2017-08, Vol.72 (8), p.2219-2224 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Adler, Amos Lifshitz, Ziv Gordon, Michal Ben-David, Debbie Khabra, Efrat Masarwa, Samira Zion, Orit Schwaber, Mitchell J Carmeli, Yehuda |
| description | The KPC-producing Klebsiella pneumoniae (KPC-KP) clonal group (CG) 258 has disseminated throughout Israeli post-acute care hospitals (PACHs). The objectives of the study were (i) to describe the evolution and (ii) to understand the dissemination modes of CG 258 in the PACH system in Israel.
KPC-KP surveillance cultures isolates were collected in Israeli PACHs in three national point-prevalence surveys: 2008, 2011 and 2013. CG 258 was identified by pilv-l PCR. WGS was performed for CG 258 isolates from 9 of 14 PACHs and data extracted for core-genome MLST (cgMLST) and for capsule polysaccharide gene cluster analysis.
The proportional representation of CG 258 among the KPC-KP isolates increased from 72 of 104 isolates (69.2%) in 2008 to 113 of 133 isolates (85%) in 2011 ( P = 0.004 for 2008 versus 2011) and remained high in 2013 [56 of 67 isolates (83.6%)]. All isolates were related to CG 258 clade 2. cgMLST phylogenetic analysis showed relative convergence in the 2008 survey, with increasing diversification in the subsequent surveys. A predominantly institutional dissemination pattern was observed only in centre F from southern Israel. A predominantly regional dissemination pattern was observed in the two PACHs in Jerusalem. The other PACHs were characterized by a combined institutional and generalized pattern, with the majority of isolates clustering within the same PACH and survey.
CG 258 clade 2 has retained its predominance despite increased diversification. Although interchanging of CG 258 strains occurred between most PACHs, local spread is the leading cause of its dissemination. |
| doi_str_mv | 10.1093/jac/dkx135 |
| format | Article |
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KPC-KP surveillance cultures isolates were collected in Israeli PACHs in three national point-prevalence surveys: 2008, 2011 and 2013. CG 258 was identified by pilv-l PCR. WGS was performed for CG 258 isolates from 9 of 14 PACHs and data extracted for core-genome MLST (cgMLST) and for capsule polysaccharide gene cluster analysis.
The proportional representation of CG 258 among the KPC-KP isolates increased from 72 of 104 isolates (69.2%) in 2008 to 113 of 133 isolates (85%) in 2011 ( P = 0.004 for 2008 versus 2011) and remained high in 2013 [56 of 67 isolates (83.6%)]. All isolates were related to CG 258 clade 2. cgMLST phylogenetic analysis showed relative convergence in the 2008 survey, with increasing diversification in the subsequent surveys. A predominantly institutional dissemination pattern was observed only in centre F from southern Israel. A predominantly regional dissemination pattern was observed in the two PACHs in Jerusalem. The other PACHs were characterized by a combined institutional and generalized pattern, with the majority of isolates clustering within the same PACH and survey.
CG 258 clade 2 has retained its predominance despite increased diversification. Although interchanging of CG 258 strains occurred between most PACHs, local spread is the leading cause of its dissemination.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkx135</identifier><identifier>PMID: 28486697</identifier><language>eng</language><publisher>England</publisher><subject>Bacterial Capsules - genetics ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Evolution, Molecular ; Genome, Bacterial ; Genotype ; Hospitals ; Humans ; Israel - epidemiology ; Klebsiella Infections - epidemiology ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae - classification ; Klebsiella pneumoniae - genetics ; Klebsiella pneumoniae - isolation & purification ; Molecular Epidemiology ; Multigene Family ; Multilocus Sequence Typing ; Retrospective Studies ; Sequence Analysis, DNA ; Subacute Care</subject><ispartof>Journal of antimicrobial chemotherapy, 2017-08, Vol.72 (8), p.2219-2224</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-7b98a3020ceab40fd42c70ef960d1587c8a8aa5410035f02d6a28f687abede5b3</citedby><cites>FETCH-LOGICAL-c323t-7b98a3020ceab40fd42c70ef960d1587c8a8aa5410035f02d6a28f687abede5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28486697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adler, Amos</creatorcontrib><creatorcontrib>Lifshitz, Ziv</creatorcontrib><creatorcontrib>Gordon, Michal</creatorcontrib><creatorcontrib>Ben-David, Debbie</creatorcontrib><creatorcontrib>Khabra, Efrat</creatorcontrib><creatorcontrib>Masarwa, Samira</creatorcontrib><creatorcontrib>Zion, Orit</creatorcontrib><creatorcontrib>Schwaber, Mitchell J</creatorcontrib><creatorcontrib>Carmeli, Yehuda</creatorcontrib><title>Evolution and dissemination of the Klebsiella pneumoniae clonal group 258 throughout Israeli post-acute care hospitals, 2008-13</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>The KPC-producing Klebsiella pneumoniae (KPC-KP) clonal group (CG) 258 has disseminated throughout Israeli post-acute care hospitals (PACHs). The objectives of the study were (i) to describe the evolution and (ii) to understand the dissemination modes of CG 258 in the PACH system in Israel.
KPC-KP surveillance cultures isolates were collected in Israeli PACHs in three national point-prevalence surveys: 2008, 2011 and 2013. CG 258 was identified by pilv-l PCR. WGS was performed for CG 258 isolates from 9 of 14 PACHs and data extracted for core-genome MLST (cgMLST) and for capsule polysaccharide gene cluster analysis.
The proportional representation of CG 258 among the KPC-KP isolates increased from 72 of 104 isolates (69.2%) in 2008 to 113 of 133 isolates (85%) in 2011 ( P = 0.004 for 2008 versus 2011) and remained high in 2013 [56 of 67 isolates (83.6%)]. All isolates were related to CG 258 clade 2. cgMLST phylogenetic analysis showed relative convergence in the 2008 survey, with increasing diversification in the subsequent surveys. A predominantly institutional dissemination pattern was observed only in centre F from southern Israel. A predominantly regional dissemination pattern was observed in the two PACHs in Jerusalem. The other PACHs were characterized by a combined institutional and generalized pattern, with the majority of isolates clustering within the same PACH and survey.
CG 258 clade 2 has retained its predominance despite increased diversification. Although interchanging of CG 258 strains occurred between most PACHs, local spread is the leading cause of its dissemination.</description><subject>Bacterial Capsules - genetics</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Evolution, Molecular</subject><subject>Genome, Bacterial</subject><subject>Genotype</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Israel - epidemiology</subject><subject>Klebsiella Infections - epidemiology</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella pneumoniae - classification</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Klebsiella pneumoniae - isolation & purification</subject><subject>Molecular Epidemiology</subject><subject>Multigene Family</subject><subject>Multilocus Sequence Typing</subject><subject>Retrospective Studies</subject><subject>Sequence Analysis, DNA</subject><subject>Subacute Care</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1P3DAQhq2qiF1oL_0BlY9VRWBsxx85VggoAokLnKOJM9n1NonTOEHtib9OYLc9zcyrR680D2NfBJwLKNTFDv1F_euPUPoDW4vcQCahEB_ZGhTozOZardhJSjsAMNq4Y7aSLnfGFHbNXq6eYztPIfYc-5rXISXqQo_vSWz4tCV-11KVArUt8qGnuYt9QOK-jT22fDPGeeBSuwVd1s02zhO_TSNSG_gQ05Shn6cFx5H4NqYhTNimMy4BXCbUJ3bULDd9PsxT9nR99Xj5M7t_uLm9_HGfeSXVlNmqcKhAgiescmjqXHoL1BQGaqGd9Q4dos4FgNINyNqgdI1xFiuqSVfqlH3b9w5j_D1TmsouJP_2U09xTqUoQBtrrZAL-n2P-jGmNFJTDmPocPxbCijfhJeL8HIvfIG_HnrnqqP6P_rPsHoF5jB9pQ</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Adler, Amos</creator><creator>Lifshitz, Ziv</creator><creator>Gordon, Michal</creator><creator>Ben-David, Debbie</creator><creator>Khabra, Efrat</creator><creator>Masarwa, Samira</creator><creator>Zion, Orit</creator><creator>Schwaber, Mitchell J</creator><creator>Carmeli, Yehuda</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Evolution and dissemination of the Klebsiella pneumoniae clonal group 258 throughout Israeli post-acute care hospitals, 2008-13</title><author>Adler, Amos ; Lifshitz, Ziv ; Gordon, Michal ; Ben-David, Debbie ; Khabra, Efrat ; Masarwa, Samira ; Zion, Orit ; Schwaber, Mitchell J ; Carmeli, Yehuda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-7b98a3020ceab40fd42c70ef960d1587c8a8aa5410035f02d6a28f687abede5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bacterial Capsules - genetics</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - microbiology</topic><topic>Evolution, Molecular</topic><topic>Genome, Bacterial</topic><topic>Genotype</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Israel - epidemiology</topic><topic>Klebsiella Infections - epidemiology</topic><topic>Klebsiella Infections - microbiology</topic><topic>Klebsiella pneumoniae - classification</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Klebsiella pneumoniae - isolation & purification</topic><topic>Molecular Epidemiology</topic><topic>Multigene Family</topic><topic>Multilocus Sequence Typing</topic><topic>Retrospective Studies</topic><topic>Sequence Analysis, DNA</topic><topic>Subacute Care</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adler, Amos</creatorcontrib><creatorcontrib>Lifshitz, Ziv</creatorcontrib><creatorcontrib>Gordon, Michal</creatorcontrib><creatorcontrib>Ben-David, Debbie</creatorcontrib><creatorcontrib>Khabra, Efrat</creatorcontrib><creatorcontrib>Masarwa, Samira</creatorcontrib><creatorcontrib>Zion, Orit</creatorcontrib><creatorcontrib>Schwaber, Mitchell J</creatorcontrib><creatorcontrib>Carmeli, Yehuda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adler, Amos</au><au>Lifshitz, Ziv</au><au>Gordon, Michal</au><au>Ben-David, Debbie</au><au>Khabra, Efrat</au><au>Masarwa, Samira</au><au>Zion, Orit</au><au>Schwaber, Mitchell J</au><au>Carmeli, Yehuda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution and dissemination of the Klebsiella pneumoniae clonal group 258 throughout Israeli post-acute care hospitals, 2008-13</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>72</volume><issue>8</issue><spage>2219</spage><epage>2224</epage><pages>2219-2224</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>The KPC-producing Klebsiella pneumoniae (KPC-KP) clonal group (CG) 258 has disseminated throughout Israeli post-acute care hospitals (PACHs). The objectives of the study were (i) to describe the evolution and (ii) to understand the dissemination modes of CG 258 in the PACH system in Israel.
KPC-KP surveillance cultures isolates were collected in Israeli PACHs in three national point-prevalence surveys: 2008, 2011 and 2013. CG 258 was identified by pilv-l PCR. WGS was performed for CG 258 isolates from 9 of 14 PACHs and data extracted for core-genome MLST (cgMLST) and for capsule polysaccharide gene cluster analysis.
The proportional representation of CG 258 among the KPC-KP isolates increased from 72 of 104 isolates (69.2%) in 2008 to 113 of 133 isolates (85%) in 2011 ( P = 0.004 for 2008 versus 2011) and remained high in 2013 [56 of 67 isolates (83.6%)]. All isolates were related to CG 258 clade 2. cgMLST phylogenetic analysis showed relative convergence in the 2008 survey, with increasing diversification in the subsequent surveys. A predominantly institutional dissemination pattern was observed only in centre F from southern Israel. A predominantly regional dissemination pattern was observed in the two PACHs in Jerusalem. The other PACHs were characterized by a combined institutional and generalized pattern, with the majority of isolates clustering within the same PACH and survey.
CG 258 clade 2 has retained its predominance despite increased diversification. Although interchanging of CG 258 strains occurred between most PACHs, local spread is the leading cause of its dissemination.</abstract><cop>England</cop><pmid>28486697</pmid><doi>10.1093/jac/dkx135</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Bacterial Capsules - genetics Cross Infection - epidemiology Cross Infection - microbiology Evolution, Molecular Genome, Bacterial Genotype Hospitals Humans Israel - epidemiology Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae - classification Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Molecular Epidemiology Multigene Family Multilocus Sequence Typing Retrospective Studies Sequence Analysis, DNA Subacute Care |
| title | Evolution and dissemination of the Klebsiella pneumoniae clonal group 258 throughout Israeli post-acute care hospitals, 2008-13 |
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