Vulvar Basal Cell Carcinoma: Four Case Reports With Immunohistochemical Study
Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were locat...
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| Veröffentlicht in: | Journal of cutaneous medicine and surgery 2017-09, Vol.21 (5), p.457-459 |
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| container_title | Journal of cutaneous medicine and surgery |
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| creator | García-de-la-Fuente, Mª Reyes Santacana, Maria Vilardell, Felip Pujol, R. M. Gari, Eloi Casanova, J. M. |
| description | Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semimucous area, a nonphotoexposed area, and a nonhairy area. We have determined the CK7 and CK19 profile of all cases; both are markers of simple epithelium with glandular differentiation. Interestingly, all cases were positively stained for CK7 and CK19. Considering that the vulvar region is rich in sebaceous and apocrine units, we hypothesise a glandular origin of BCCs situated in the vulvar region. |
| doi_str_mv | 10.1177/1203475417712498 |
| format | Article |
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Considering that the vulvar region is rich in sebaceous and apocrine units, we hypothesise a glandular origin of BCCs situated in the vulvar region.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Basal Cell - metabolism</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Case reports</subject><subject>Female</subject><subject>Humans</subject><subject>Keratin-19 - metabolism</subject><subject>Keratin-7 - metabolism</subject><subject>Middle Aged</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Vulvar Neoplasms - metabolism</subject><subject>Vulvar Neoplasms - pathology</subject><issn>1203-4754</issn><issn>1615-7109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kN1LwzAUxYMobk7ffZKCL75U702TNvFNh1NhIvj5WNI0dR39mEkr7L83Y1Nh4Etyk_s7JzeHkGOEc8QkuUAKEUs48zVSJsUOGWKMPEwQ5K6vfTtc9QfkwLk5ACBytk8GVPCYSwpD8vDWV1_KBtfKqSoYm8ovyuqyaWt1GUza3vqzM8GTWbS2c8F72c2C-7rum3ZWuq7VM1OX2kufuz5fHpK9QlXOHG32EXmd3LyM78Lp4-39-GoaagZJF-YoUNAoAxrnAIpGAgQWqmBK8lzm_pJKyjOtdFEoaXSsVJRnXlqgRCl4NCJna9-FbT9747q0Lp32w6vGtL1LUQKTIKKIefR0C537TzV-upQiT5iAhKOnYE1p2zpnTZEubFkru0wR0lXU6XbUXnKyMe6z2uS_gp9sPRCuAac-zN-r_xp-A73hhB8</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>García-de-la-Fuente, Mª Reyes</creator><creator>Santacana, Maria</creator><creator>Vilardell, Felip</creator><creator>Pujol, R. 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| subjects | Aged Aged, 80 and over Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Case reports Female Humans Keratin-19 - metabolism Keratin-7 - metabolism Middle Aged Skin cancer Skin Neoplasms - metabolism Skin Neoplasms - pathology Vulvar Neoplasms - metabolism Vulvar Neoplasms - pathology |
| title | Vulvar Basal Cell Carcinoma: Four Case Reports With Immunohistochemical Study |
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