Histone Deacetylase Inhibitors Sensitize Murine B16F10 Melanoma Cells to Carbon Ion Irradiation by Inducing G1 Phase Arrest

Epigenetic processes, in addition to genetic abnormalities, play a critical role in refractory malignant diseases and cause the unresponsiveness to various chemotherapeutic regimens and radiotherapy. Herein we demonstrate that histone deacetylase inhibitors (HDACis) can be used to sensitize malignan...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/06/01, Vol.40(6), pp.844-851
Hauptverfasser:	Saito, Katsuyo, Funayama, Tomoo, Yokota, Yuichiro, Murakami, Takashi, Kobayashi, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Cancer Carbon carbon ion irradiation Cell cycle Cell Line, Tumor Chromatin combination therapy Diseases DNA repair Exposure G1 arrest G1 phase G1 Phase Cell Cycle Checkpoints - drug effects Gamma Rays Genetic abnormalities Heavy Ion Radiotherapy Histone deacetylase histone deacetylase inhibitor Histone Deacetylase Inhibitors - pharmacology Histones - metabolism Homologous recombination Homology Inhibitors Ion irradiation Ions Irradiation Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Melanoma, Experimental - radiotherapy Mice Radiation therapy Radiation-Sensitizing Agents - pharmacology radiosensitizer Radiosensitizers Skin cancer Trichostatin A Valproic acid
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