Amelioration of the Deleterious Pleiotropic Effects of an Adaptive Mutation in Bacillus subtilis
The deleterious pleiotropic effects of an adaptive mutation may be ameliorated by one of two modes of evolution: (1) by replacement, in which an adaptive mutation with harmful pleiotropic effects is replaced by one that confers an equal benefit but at less cost; or (2) by compensatory evolution, in...
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| Veröffentlicht in: | Evolution 1994-02, Vol.48 (1), p.81-95 |
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| creator | Cohan, Frederick M. King, Elaine C. Zawadzki, Piotr |
| description | The deleterious pleiotropic effects of an adaptive mutation may be ameliorated by one of two modes of evolution: (1) by replacement, in which an adaptive mutation with harmful pleiotropic effects is replaced by one that confers an equal benefit but at less cost; or (2) by compensatory evolution, in which natural selection favors modifiers at other loci that compensate for the deleterious effects of the mutant allele. In this study, we have measured the potential of these two modes of evolution to ameliorate the deleterious pleiotropic effects of resistance to the antibiotic rifampicin in the soil bacterium Bacillus subtilis. One approach was to measure the fitness cost of a series of spontaneous rifampicin-resistance mutations from each of several strains. The potential for amelioration by the replacement mode was estimated by the variation in fitness cost among the mutants of a single strain. Another approach was to introduce a series of different rifampicin-resistance alleles into a diversity of strains, and to measure the fitness cost of rifampicin resistance for each allele-by-strain combination. The potential for amelioration by the replacement mode was estimated by the variation in fitness costs among rifampicin-resistance alleles; the potential for compensatory evolution was estimated by variation in the fitness cost of rifampicin resistance among strains. This study has shown that the cost of rifampicin resistance may be ameliorated by both the compensatory and replacement modes. |
| doi_str_mv | 10.1111/j.1558-5646.1994.tb01296.x |
| format | Article |
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In this study, we have measured the potential of these two modes of evolution to ameliorate the deleterious pleiotropic effects of resistance to the antibiotic rifampicin in the soil bacterium Bacillus subtilis. One approach was to measure the fitness cost of a series of spontaneous rifampicin-resistance mutations from each of several strains. The potential for amelioration by the replacement mode was estimated by the variation in fitness cost among the mutants of a single strain. Another approach was to introduce a series of different rifampicin-resistance alleles into a diversity of strains, and to measure the fitness cost of rifampicin resistance for each allele-by-strain combination. The potential for amelioration by the replacement mode was estimated by the variation in fitness costs among rifampicin-resistance alleles; the potential for compensatory evolution was estimated by variation in the fitness cost of rifampicin resistance among strains. This study has shown that the cost of rifampicin resistance may be ameliorated by both the compensatory and replacement modes.</description><identifier>ISSN: 0014-3820</identifier><identifier>EISSN: 1558-5646</identifier><identifier>DOI: 10.1111/j.1558-5646.1994.tb01296.x</identifier><identifier>PMID: 28567791</identifier><language>eng</language><publisher>Malden, MA: Society for the Study of Evolution</publisher><subject>Alleles ; Bacillus subtilis ; Bacteria ; Bacteriology ; Biological and medical sciences ; compensatory evolution ; DNA ; Ecological competition ; Evolution ; Evolutionary genetics ; fitness ; Fundamental and applied biological sciences. Psychology ; Genetic loci ; Genetic mutation ; Genetic variation ; Genetics ; Genomics ; Microbiology ; Mutation ; Mutation (Biology) ; pleiotropy ; Polymerase chain reaction ; resistance ; rifampicin</subject><ispartof>Evolution, 1994-02, Vol.48 (1), p.81-95</ispartof><rights>Copyright 1994 The Society for the Study of Evolution</rights><rights>1994 The Society for the Study of Evolution</rights><rights>1994 INIST-CNRS</rights><rights>1994 The Society for the Study of Evolution.</rights><rights>COPYRIGHT 1994 Society for the Study of Evolution</rights><rights>Copyright Society for the Study of Evolution Feb 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5656-b87961f0ad03123c2bea1d33ade2fc3dc412af8f6b964c712f190e2e5646aa2b3</citedby><cites>FETCH-LOGICAL-c5656-b87961f0ad03123c2bea1d33ade2fc3dc412af8f6b964c712f190e2e5646aa2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2410005$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2410005$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4261531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28567791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohan, Frederick M.</creatorcontrib><creatorcontrib>King, Elaine C.</creatorcontrib><creatorcontrib>Zawadzki, Piotr</creatorcontrib><title>Amelioration of the Deleterious Pleiotropic Effects of an Adaptive Mutation in Bacillus subtilis</title><title>Evolution</title><addtitle>Evolution</addtitle><description>The deleterious pleiotropic effects of an adaptive mutation may be ameliorated by one of two modes of evolution: (1) by replacement, in which an adaptive mutation with harmful pleiotropic effects is replaced by one that confers an equal benefit but at less cost; or (2) by compensatory evolution, in which natural selection favors modifiers at other loci that compensate for the deleterious effects of the mutant allele. In this study, we have measured the potential of these two modes of evolution to ameliorate the deleterious pleiotropic effects of resistance to the antibiotic rifampicin in the soil bacterium Bacillus subtilis. One approach was to measure the fitness cost of a series of spontaneous rifampicin-resistance mutations from each of several strains. The potential for amelioration by the replacement mode was estimated by the variation in fitness cost among the mutants of a single strain. Another approach was to introduce a series of different rifampicin-resistance alleles into a diversity of strains, and to measure the fitness cost of rifampicin resistance for each allele-by-strain combination. The potential for amelioration by the replacement mode was estimated by the variation in fitness costs among rifampicin-resistance alleles; the potential for compensatory evolution was estimated by variation in the fitness cost of rifampicin resistance among strains. This study has shown that the cost of rifampicin resistance may be ameliorated by both the compensatory and replacement modes.</description><subject>Alleles</subject><subject>Bacillus subtilis</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>compensatory evolution</subject><subject>DNA</subject><subject>Ecological competition</subject><subject>Evolution</subject><subject>Evolutionary genetics</subject><subject>fitness</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic loci</subject><subject>Genetic mutation</subject><subject>Genetic variation</subject><subject>Genetics</subject><subject>Genomics</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Mutation (Biology)</subject><subject>pleiotropy</subject><subject>Polymerase chain reaction</subject><subject>resistance</subject><subject>rifampicin</subject><issn>0014-3820</issn><issn>1558-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqV0ktv1DAQAOAIgehS-AsoqhDiQBY_YifuiaUsD6moHICrcZxx8cobL7YD7b_HIcuCUIVEcojlfDP22FMUJxgtcX6ebZaYsbZivOZLLES9TB3CRPDl1a1icfh1u1gghOuKtgQdFfdi3CCEBMPibnFEWsabRuBF8Xm1BWd9UMn6ofSmTF-gfAkOEgTrx1i-d2B9Cn5ndbk2BnSKE1NDuerVLtlvUL4b0xxuh_KF0ta5HBfHLlln4_3ijlEuwoP997j4-Gr94exNdX7x-u3Z6rzSjDNedW0jODZI9YhiQjXpQOGeUtUDMZr2usZEmdbwTvBaN5gYLBAQmCpVinT0uHgy590F_3WEmOTWRg3OqQFyHTLzuhWCkDbTx_-mvGkpryd48hfc-DEMuQxJSJPz1Rhn9HRGl8qBtIPJp6X0JQwQlPMDGJunV5jxliJGM69u4PntYWv1Tf509jr4GAMYuQt2q8K1xEhO7SA3crpzOZ2EnNpB7ttBXuXgh_sCxm4L_SH01_1n8GgPVNTKmaAGbePB1YRjRif2fGbf8-au_2MHcv3p4ufw90qbmHz4MwWhqJGkxrk9Gf0BIQzcoQ</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>Cohan, Frederick M.</creator><creator>King, Elaine C.</creator><creator>Zawadzki, Piotr</creator><general>Society for the Study of Evolution</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>199402</creationdate><title>Amelioration of the Deleterious Pleiotropic Effects of an Adaptive Mutation in Bacillus subtilis</title><author>Cohan, Frederick M. ; King, Elaine C. ; Zawadzki, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5656-b87961f0ad03123c2bea1d33ade2fc3dc412af8f6b964c712f190e2e5646aa2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Alleles</topic><topic>Bacillus subtilis</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>compensatory evolution</topic><topic>DNA</topic><topic>Ecological competition</topic><topic>Evolution</topic><topic>Evolutionary genetics</topic><topic>fitness</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic loci</topic><topic>Genetic mutation</topic><topic>Genetic variation</topic><topic>Genetics</topic><topic>Genomics</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Mutation (Biology)</topic><topic>pleiotropy</topic><topic>Polymerase chain reaction</topic><topic>resistance</topic><topic>rifampicin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohan, Frederick M.</creatorcontrib><creatorcontrib>King, Elaine C.</creatorcontrib><creatorcontrib>Zawadzki, Piotr</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohan, Frederick M.</au><au>King, Elaine C.</au><au>Zawadzki, Piotr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amelioration of the Deleterious Pleiotropic Effects of an Adaptive Mutation in Bacillus subtilis</atitle><jtitle>Evolution</jtitle><addtitle>Evolution</addtitle><date>1994-02</date><risdate>1994</risdate><volume>48</volume><issue>1</issue><spage>81</spage><epage>95</epage><pages>81-95</pages><issn>0014-3820</issn><eissn>1558-5646</eissn><abstract>The deleterious pleiotropic effects of an adaptive mutation may be ameliorated by one of two modes of evolution: (1) by replacement, in which an adaptive mutation with harmful pleiotropic effects is replaced by one that confers an equal benefit but at less cost; or (2) by compensatory evolution, in which natural selection favors modifiers at other loci that compensate for the deleterious effects of the mutant allele. In this study, we have measured the potential of these two modes of evolution to ameliorate the deleterious pleiotropic effects of resistance to the antibiotic rifampicin in the soil bacterium Bacillus subtilis. One approach was to measure the fitness cost of a series of spontaneous rifampicin-resistance mutations from each of several strains. The potential for amelioration by the replacement mode was estimated by the variation in fitness cost among the mutants of a single strain. Another approach was to introduce a series of different rifampicin-resistance alleles into a diversity of strains, and to measure the fitness cost of rifampicin resistance for each allele-by-strain combination. The potential for amelioration by the replacement mode was estimated by the variation in fitness costs among rifampicin-resistance alleles; the potential for compensatory evolution was estimated by variation in the fitness cost of rifampicin resistance among strains. 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| ispartof | Evolution, 1994-02, Vol.48 (1), p.81-95 |
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| source | JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alleles Bacillus subtilis Bacteria Bacteriology Biological and medical sciences compensatory evolution DNA Ecological competition Evolution Evolutionary genetics fitness Fundamental and applied biological sciences. Psychology Genetic loci Genetic mutation Genetic variation Genetics Genomics Microbiology Mutation Mutation (Biology) pleiotropy Polymerase chain reaction resistance rifampicin |
| title | Amelioration of the Deleterious Pleiotropic Effects of an Adaptive Mutation in Bacillus subtilis |
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