Facile synthesis of novel spiroheterocycles via diastereoselective aziridination of cyclic enones
A collection of novel spiroheterocycles with strained aziridine moieties have been facilely synthesized by using easily accessible starting materials under mild reaction conditions. This procedure is robust, scalable and highly diastereoselective, and also features broad substrate scope. In addition...
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| Veröffentlicht in: | RSC advances 2017-01, Vol.7 (34), p.21175-21179 |
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| container_end_page | 21179 |
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| container_issue | 34 |
| container_start_page | 21175 |
| container_title | RSC advances |
| container_volume | 7 |
| creator | Yang, Kai-Chuan Li, Jun-Long Shen, Xu-Dong Li, Qiang Leng, Hai-Jun Huang, Qian Zheng, Peng-Kun Gou, Xiao-Jun Zhi, Yong-Gang |
| description | A collection of novel spiroheterocycles with strained aziridine moieties have been facilely synthesized by using easily accessible starting materials under mild reaction conditions. This procedure is robust, scalable and highly diastereoselective, and also features broad substrate scope. In addition, some of the products show promising
in vitro
biological activity against a spectrum of pathogens, which might be considered as a clue for the discovery of new antimicrobial agents. |
| doi_str_mv | 10.1039/C6RA28508B |
| format | Article |
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in vitro
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in vitro
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Accessibility Antiinfectives and antibacterials Collection Pathogens Reagents Robustness Synthesis Synthesis (chemistry) |
| title | Facile synthesis of novel spiroheterocycles via diastereoselective aziridination of cyclic enones |
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