MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherin

Objective To investigate the roles of miR-145 in lung adenocarcinoma (LAC) and to clarify the regulation of N-cadherin by miR-145. Results In 57 paired clinical LAC tissues, diminished miR-145 was significantly correlated with the lymph node metastasis and was negatively correlated with N-cadherin m...

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Veröffentlicht in:	Biotechnology letters 2017-05, Vol.39 (5), p.701-710
Hauptverfasser:	Mo, Dongping, Yang, Daheng, Xiao, Xuelian, Sun, Ruihong, Huang, Lei, Xu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Antigens, CD - genetics Antigens, CD - metabolism Applied Microbiology Binding Biochemistry Biomedical and Life Sciences Biotechnology Cadherins - genetics Cadherins - metabolism Cell Movement - genetics Cohort Studies Control Correlation Female Gene expression Gene Knockdown Techniques Humans Life Sciences Lung Neoplasms - epidemiology Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lungs Lymph Male Microbiology MicroRNAs - analysis MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Migration Neoplasm Invasiveness - genetics Original Research Paper
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