Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis

Background Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis. Methods Thirty‐two mice were allocated equally into 4 groups (n = 8). In group A (control), we perf...

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Veröffentlicht in:	International forum of allergy & rhinology 2017-08, Vol.7 (8), p.763-769
Hauptverfasser:	Jung, Ah‐Yeoun, Heo, Min‐Jeong, Kim, Young Hyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens allergic rhinitis Alveoli Animals Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use Asthma Asthma - blood Asthma - drug therapy Asthma - genetics Asthma - immunology Bcl-2 protein bcl-2-Associated X Protein - genetics Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchus Caspase Caspase-3 Cyclooxygenase-2 Cytokines - immunology Dietary supplements Female Gene Expression Regulation - drug effects Glucosamine Glucosamine - pharmacology Glucosamine - therapeutic use Heme Heme Oxygenase-1 - genetics heme oxygenase‐1 Hypoxia-Inducible Factor 1, alpha Subunit - genetics hypoxia‐inducible factor‐1 Immunoglobulin E Immunoglobulin E - blood Inflammation Interleukin 1 Interleukin 17 Interleukin 4 Interleukin 5 Interleukin 6 Leukocyte Count Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lung - pathology Lymphocytes Mice, Inbred BALB C Nasal Mucosa - pathology Nose Ovalbumin Peanuts Polymerase chain reaction Rhinitis Rhinitis, Allergic - blood Rhinitis, Allergic - drug therapy Rhinitis, Allergic - genetics Rhinitis, Allergic - immunology Rodents superoxide dismutase Superoxide Dismutase - genetics Vascular endothelial growth factor γ-Interferon
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