Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis
Background Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis. Methods Thirty‐two mice were allocated equally into 4 groups (n = 8). In group A (control), we perf...
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| description | Background
Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis.
Methods
Thirty‐two mice were allocated equally into 4 groups (n = 8). In group A (control), we performed intraperitoneal/intranasal challenge using sterile saline. In group B (asthma/rhinitis), we used ovalbumin for intraperitoneal/intranasal challenge to induce allergic asthma and rhinitis. In groups C and D (GlcN treatment), mice were given 1% and 5% GlcN throughout the period of ovalbumin challenge, respectively. We measured serum total and ovalbumin‐specific immunoglobulin E (IgE), cytokine titers (interleukin‐1, ‐4, ‐5, ‐6, ‐10, and ‐17; tumor necrosis factor‐α; and interferon‐γ), and the number of inflammatory cells (eosinophils, neutrophils, lymphocytes) in bronchoalveolar lavage (BAL) fluid. We also performed histopathologic examination of the lung and nasal cavity. Finally, we performed real‐time polymerase chain reaction for the genes Bcl‐2, EC‐SOD, VEGF, caspase‐3, Bax, COX‐2, Hif‐1α, and heme oxygenase‐1.
Results
Compared with group B, group D had significant serum total and ovalbumin‐specific IgE decreases after GlcN treatment (p < 0.05). Titers for IL‐4, IL‐5, IL‐6, and IL‐17 in BAL fluid were significantly decreased in group D (p < 0.05). Eosinophils in BAL fluid were significantly decreased in group D compared with group B (p < 0.05). Groups C and D showed significant improvement of inflammation compared with group B. Group D had significant downregulation of EC‐SOD, Bax, Hif‐1α, and heme oxygenase‐1 compared with group B.
Conclusion
GlcN had a significant antiallergic effect in mice with allergic asthma and rhinitis. |
| doi_str_mv | 10.1002/alr.21967 |
| format | Article |
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Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis.
Methods
Thirty‐two mice were allocated equally into 4 groups (n = 8). In group A (control), we performed intraperitoneal/intranasal challenge using sterile saline. In group B (asthma/rhinitis), we used ovalbumin for intraperitoneal/intranasal challenge to induce allergic asthma and rhinitis. In groups C and D (GlcN treatment), mice were given 1% and 5% GlcN throughout the period of ovalbumin challenge, respectively. We measured serum total and ovalbumin‐specific immunoglobulin E (IgE), cytokine titers (interleukin‐1, ‐4, ‐5, ‐6, ‐10, and ‐17; tumor necrosis factor‐α; and interferon‐γ), and the number of inflammatory cells (eosinophils, neutrophils, lymphocytes) in bronchoalveolar lavage (BAL) fluid. We also performed histopathologic examination of the lung and nasal cavity. Finally, we performed real‐time polymerase chain reaction for the genes Bcl‐2, EC‐SOD, VEGF, caspase‐3, Bax, COX‐2, Hif‐1α, and heme oxygenase‐1.
Results
Compared with group B, group D had significant serum total and ovalbumin‐specific IgE decreases after GlcN treatment (p < 0.05). Titers for IL‐4, IL‐5, IL‐6, and IL‐17 in BAL fluid were significantly decreased in group D (p < 0.05). Eosinophils in BAL fluid were significantly decreased in group D compared with group B (p < 0.05). Groups C and D showed significant improvement of inflammation compared with group B. Group D had significant downregulation of EC‐SOD, Bax, Hif‐1α, and heme oxygenase‐1 compared with group B.
Conclusion
GlcN had a significant antiallergic effect in mice with allergic asthma and rhinitis.</description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.21967</identifier><identifier>PMID: 28558148</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Allergens ; allergic rhinitis ; Alveoli ; Animals ; Anti-Allergic Agents - pharmacology ; Anti-Allergic Agents - therapeutic use ; Asthma ; Asthma - blood ; Asthma - drug therapy ; Asthma - genetics ; Asthma - immunology ; Bcl-2 protein ; bcl-2-Associated X Protein - genetics ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoalveolar Lavage Fluid - immunology ; Bronchus ; Caspase ; Caspase-3 ; Cyclooxygenase-2 ; Cytokines - immunology ; Dietary supplements ; Female ; Gene Expression Regulation - drug effects ; Glucosamine ; Glucosamine - pharmacology ; Glucosamine - therapeutic use ; Heme ; Heme Oxygenase-1 - genetics ; heme oxygenase‐1 ; Hypoxia-Inducible Factor 1, alpha Subunit - genetics ; hypoxia‐inducible factor‐1 ; Immunoglobulin E ; Immunoglobulin E - blood ; Inflammation ; Interleukin 1 ; Interleukin 17 ; Interleukin 4 ; Interleukin 5 ; Interleukin 6 ; Leukocyte Count ; Leukocytes (eosinophilic) ; Leukocytes (neutrophilic) ; Lung - pathology ; Lymphocytes ; Mice, Inbred BALB C ; Nasal Mucosa - pathology ; Nose ; Ovalbumin ; Peanuts ; Polymerase chain reaction ; Rhinitis ; Rhinitis, Allergic - blood ; Rhinitis, Allergic - drug therapy ; Rhinitis, Allergic - genetics ; Rhinitis, Allergic - immunology ; Rodents ; superoxide dismutase ; Superoxide Dismutase - genetics ; Vascular endothelial growth factor ; γ-Interferon</subject><ispartof>International forum of allergy & rhinology, 2017-08, Vol.7 (8), p.763-769</ispartof><rights>2017 ARS‐AAOA, LLC</rights><rights>2017 ARS-AAOA, LLC.</rights><rights>2017 ARS-AAOA, LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-116056d80455b4a7f50f4c11ecddad151949c009585d058d2a3647b7bc8c163c3</citedby><cites>FETCH-LOGICAL-c3537-116056d80455b4a7f50f4c11ecddad151949c009585d058d2a3647b7bc8c163c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falr.21967$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falr.21967$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28558148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Ah‐Yeoun</creatorcontrib><creatorcontrib>Heo, Min‐Jeong</creatorcontrib><creatorcontrib>Kim, Young Hyo</creatorcontrib><title>Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description>Background
Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis.
Methods
Thirty‐two mice were allocated equally into 4 groups (n = 8). In group A (control), we performed intraperitoneal/intranasal challenge using sterile saline. In group B (asthma/rhinitis), we used ovalbumin for intraperitoneal/intranasal challenge to induce allergic asthma and rhinitis. In groups C and D (GlcN treatment), mice were given 1% and 5% GlcN throughout the period of ovalbumin challenge, respectively. We measured serum total and ovalbumin‐specific immunoglobulin E (IgE), cytokine titers (interleukin‐1, ‐4, ‐5, ‐6, ‐10, and ‐17; tumor necrosis factor‐α; and interferon‐γ), and the number of inflammatory cells (eosinophils, neutrophils, lymphocytes) in bronchoalveolar lavage (BAL) fluid. We also performed histopathologic examination of the lung and nasal cavity. Finally, we performed real‐time polymerase chain reaction for the genes Bcl‐2, EC‐SOD, VEGF, caspase‐3, Bax, COX‐2, Hif‐1α, and heme oxygenase‐1.
Results
Compared with group B, group D had significant serum total and ovalbumin‐specific IgE decreases after GlcN treatment (p < 0.05). Titers for IL‐4, IL‐5, IL‐6, and IL‐17 in BAL fluid were significantly decreased in group D (p < 0.05). Eosinophils in BAL fluid were significantly decreased in group D compared with group B (p < 0.05). Groups C and D showed significant improvement of inflammation compared with group B. Group D had significant downregulation of EC‐SOD, Bax, Hif‐1α, and heme oxygenase‐1 compared with group B.
Conclusion
GlcN had a significant antiallergic effect in mice with allergic asthma and rhinitis.</description><subject>Allergens</subject><subject>allergic rhinitis</subject><subject>Alveoli</subject><subject>Animals</subject><subject>Anti-Allergic Agents - pharmacology</subject><subject>Anti-Allergic Agents - therapeutic use</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - drug therapy</subject><subject>Asthma - genetics</subject><subject>Asthma - immunology</subject><subject>Bcl-2 protein</subject><subject>bcl-2-Associated X Protein - genetics</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Bronchus</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cyclooxygenase-2</subject><subject>Cytokines - immunology</subject><subject>Dietary supplements</subject><subject>Female</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucosamine</subject><subject>Glucosamine - pharmacology</subject><subject>Glucosamine - therapeutic use</subject><subject>Heme</subject><subject>Heme Oxygenase-1 - genetics</subject><subject>heme oxygenase‐1</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</subject><subject>hypoxia‐inducible factor‐1</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 17</subject><subject>Interleukin 4</subject><subject>Interleukin 5</subject><subject>Interleukin 6</subject><subject>Leukocyte Count</subject><subject>Leukocytes (eosinophilic)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lung - pathology</subject><subject>Lymphocytes</subject><subject>Mice, Inbred BALB C</subject><subject>Nasal Mucosa - pathology</subject><subject>Nose</subject><subject>Ovalbumin</subject><subject>Peanuts</subject><subject>Polymerase chain reaction</subject><subject>Rhinitis</subject><subject>Rhinitis, Allergic - blood</subject><subject>Rhinitis, Allergic - drug therapy</subject><subject>Rhinitis, Allergic - genetics</subject><subject>Rhinitis, Allergic - immunology</subject><subject>Rodents</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - genetics</subject><subject>Vascular endothelial growth factor</subject><subject>γ-Interferon</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10FFLAyEAB3CJosXaQ18ghF7q4Ta9U897HKNWMCiinsVTrzm8u6V3jH37rFt7CBJBwZ9_9A_AFUZTjFA6k85PU1yw_ARcpIikCSs4OT3uczYCkxA2KA6KKcX5ORilnFKOCb8AL0vXqzbI2jYGrmWAsomzs9I54z-sgqaqjOqgbWBtlYE7263h8VCGbl3LeEFDv7aN7Wy4BGeVdMFMDusYvD_cvy0ek9Xz8mkxXyUqo1meYMwQZZojQmlJZF5RVBGFsVFaS40pLkihECoopxpRrlOZMZKXeam4wixT2RjcDrlb3372JnSitkEZ52Rj2j4IXMT_Z7zgKNKbP3TT9r6Jr4sqpTxjKcuiuhuU8m0I3lRi620t_V5gJL6bFrFp8dN0tNeHxL6sjT7K314jmA1gZ53Z_58k5qvXIfIL1_OFjg</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Jung, Ah‐Yeoun</creator><creator>Heo, Min‐Jeong</creator><creator>Kim, Young Hyo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis</title><author>Jung, Ah‐Yeoun ; Heo, Min‐Jeong ; Kim, Young Hyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-116056d80455b4a7f50f4c11ecddad151949c009585d058d2a3647b7bc8c163c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Allergens</topic><topic>allergic rhinitis</topic><topic>Alveoli</topic><topic>Animals</topic><topic>Anti-Allergic Agents - pharmacology</topic><topic>Anti-Allergic Agents - therapeutic use</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - drug therapy</topic><topic>Asthma - genetics</topic><topic>Asthma - immunology</topic><topic>Bcl-2 protein</topic><topic>bcl-2-Associated X Protein - genetics</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Bronchus</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cyclooxygenase-2</topic><topic>Cytokines - immunology</topic><topic>Dietary supplements</topic><topic>Female</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glucosamine</topic><topic>Glucosamine - pharmacology</topic><topic>Glucosamine - therapeutic use</topic><topic>Heme</topic><topic>Heme Oxygenase-1 - genetics</topic><topic>heme oxygenase‐1</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</topic><topic>hypoxia‐inducible factor‐1</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin 17</topic><topic>Interleukin 4</topic><topic>Interleukin 5</topic><topic>Interleukin 6</topic><topic>Leukocyte Count</topic><topic>Leukocytes (eosinophilic)</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lung - pathology</topic><topic>Lymphocytes</topic><topic>Mice, Inbred BALB C</topic><topic>Nasal Mucosa - pathology</topic><topic>Nose</topic><topic>Ovalbumin</topic><topic>Peanuts</topic><topic>Polymerase chain reaction</topic><topic>Rhinitis</topic><topic>Rhinitis, Allergic - blood</topic><topic>Rhinitis, Allergic - drug therapy</topic><topic>Rhinitis, Allergic - genetics</topic><topic>Rhinitis, Allergic - immunology</topic><topic>Rodents</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - genetics</topic><topic>Vascular endothelial growth factor</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Ah‐Yeoun</creatorcontrib><creatorcontrib>Heo, Min‐Jeong</creatorcontrib><creatorcontrib>Kim, Young Hyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Ah‐Yeoun</au><au>Heo, Min‐Jeong</au><au>Kim, Young Hyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2017-08</date><risdate>2017</risdate><volume>7</volume><issue>8</issue><spage>763</spage><epage>769</epage><pages>763-769</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract>Background
Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis.
Methods
Thirty‐two mice were allocated equally into 4 groups (n = 8). In group A (control), we performed intraperitoneal/intranasal challenge using sterile saline. In group B (asthma/rhinitis), we used ovalbumin for intraperitoneal/intranasal challenge to induce allergic asthma and rhinitis. In groups C and D (GlcN treatment), mice were given 1% and 5% GlcN throughout the period of ovalbumin challenge, respectively. We measured serum total and ovalbumin‐specific immunoglobulin E (IgE), cytokine titers (interleukin‐1, ‐4, ‐5, ‐6, ‐10, and ‐17; tumor necrosis factor‐α; and interferon‐γ), and the number of inflammatory cells (eosinophils, neutrophils, lymphocytes) in bronchoalveolar lavage (BAL) fluid. We also performed histopathologic examination of the lung and nasal cavity. Finally, we performed real‐time polymerase chain reaction for the genes Bcl‐2, EC‐SOD, VEGF, caspase‐3, Bax, COX‐2, Hif‐1α, and heme oxygenase‐1.
Results
Compared with group B, group D had significant serum total and ovalbumin‐specific IgE decreases after GlcN treatment (p < 0.05). Titers for IL‐4, IL‐5, IL‐6, and IL‐17 in BAL fluid were significantly decreased in group D (p < 0.05). Eosinophils in BAL fluid were significantly decreased in group D compared with group B (p < 0.05). Groups C and D showed significant improvement of inflammation compared with group B. Group D had significant downregulation of EC‐SOD, Bax, Hif‐1α, and heme oxygenase‐1 compared with group B.
Conclusion
GlcN had a significant antiallergic effect in mice with allergic asthma and rhinitis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28558148</pmid><doi>10.1002/alr.21967</doi><tpages>7</tpages></addata></record> |
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| subjects | Allergens allergic rhinitis Alveoli Animals Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use Asthma Asthma - blood Asthma - drug therapy Asthma - genetics Asthma - immunology Bcl-2 protein bcl-2-Associated X Protein - genetics Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchus Caspase Caspase-3 Cyclooxygenase-2 Cytokines - immunology Dietary supplements Female Gene Expression Regulation - drug effects Glucosamine Glucosamine - pharmacology Glucosamine - therapeutic use Heme Heme Oxygenase-1 - genetics heme oxygenase‐1 Hypoxia-Inducible Factor 1, alpha Subunit - genetics hypoxia‐inducible factor‐1 Immunoglobulin E Immunoglobulin E - blood Inflammation Interleukin 1 Interleukin 17 Interleukin 4 Interleukin 5 Interleukin 6 Leukocyte Count Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lung - pathology Lymphocytes Mice, Inbred BALB C Nasal Mucosa - pathology Nose Ovalbumin Peanuts Polymerase chain reaction Rhinitis Rhinitis, Allergic - blood Rhinitis, Allergic - drug therapy Rhinitis, Allergic - genetics Rhinitis, Allergic - immunology Rodents superoxide dismutase Superoxide Dismutase - genetics Vascular endothelial growth factor γ-Interferon |
| title | Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis |
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