Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

The maintenance of immune homeostasis requires regulatory T cells (Tregs). Given their intrinsic self-reactivity, Tregs must stably maintain a suppressive phenotype to avoid autoimmunity. We report that impaired expression of the transcription factor (TF) Helios by FoxP3+ CD4 and Qa-1–restricted CD8...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2015-10, Vol.350 (6258), p.334-339
Hauptverfasser:	Kim, Hye-Jung, Barnitz, R. Anthony, Kreslavsky, Taras, Brown, Flavian D., Moffett, Howell, Lemieux, Madeleine E., Kaygusuz, Yasemin, Meissner, Torsten, Holderried, Tobias A. W., Chan, Susan, Kastner, Philippe, Haining, W. Nicholas, Cantor, Harvey
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Autoimmunity - genetics Autoimmunity - immunology CD8-Positive T-Lymphocytes - immunology DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Forkhead Transcription Factors - immunology Gene Expression Genetics Government regulations Immune system Individualized Instruction Inflammation Kidney - immunology Liver - immunology Lymphocyte Activation Lymphocytes Maintenance Mice Mice, Inbred C57BL Mice, Transgenic Pancreas - immunology Pathogens Protein expression STAT5 Transcription Factor - metabolism T-Lymphocytes, Regulatory - immunology Terminals Transcription Factors - biosynthesis Transcription Factors - genetics
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