Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases
Recently TRG, necrosis grade and the rate of viable cancer cells of colorectal liver metastases were correlated with the response to chemotherapy treatments, whereas K-RAS mutations and c-MET over-expression were correlated with the prognosis. 58 resection specimens were assessed for regression grad...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2017-08, Vol.213 (8), p.1002-1009 |
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| container_title | Pathology, research and practice |
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| creator | Lorenzon, Laura Ricca, Luana Pilozzi, Emanuela Lemoine, Antoinette Riggio, Valentina Giudice, Maria Teresa Mallel, Giuseppe Fochetti, Flavio Balducci, Genoveffa |
| description | Recently TRG, necrosis grade and the rate of viable cancer cells of colorectal liver metastases were correlated with the response to chemotherapy treatments, whereas K-RAS mutations and c-MET over-expression were correlated with the prognosis.
58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly. We investigated the K-RAS mutational profile, the c-MET over-expression along with patients’ survivals curves.
Patients undergone neo-adjuvant treatment presented significant higher fibrosis rates and lower rates of viable cells. 36.7% of the patients had a K-RAS mutation and the 26.7% presented c-MET over-expression, but these features did not correlate with patients’ clinical/pathological data. Survival analysis documented that K-RAS WT patients presenting c-MET over-expression had worse outcomes.
Fibrosis and the rate of viable cells significantly correlate with the response to chemotherapy treatments. c-MET is a promising marker in K-RAS WT patients. |
| doi_str_mv | 10.1016/j.prp.2017.04.013 |
| format | Article |
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58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly. We investigated the K-RAS mutational profile, the c-MET over-expression along with patients’ survivals curves.
Patients undergone neo-adjuvant treatment presented significant higher fibrosis rates and lower rates of viable cells. 36.7% of the patients had a K-RAS mutation and the 26.7% presented c-MET over-expression, but these features did not correlate with patients’ clinical/pathological data. Survival analysis documented that K-RAS WT patients presenting c-MET over-expression had worse outcomes.
Fibrosis and the rate of viable cells significantly correlate with the response to chemotherapy treatments. c-MET is a promising marker in K-RAS WT patients.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2017.04.013</identifier><identifier>PMID: 28559118</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - secondary ; Adenocarcinoma - therapy ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; C-MET ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - therapy ; Disease-Free Survival ; DNA Mutational Analysis ; Female ; Fibrosis - pathology ; Humans ; K-RAS ; Kaplan-Meier Estimate ; Liver metastasis ; Liver Neoplasms - genetics ; Liver Neoplasms - secondary ; Liver Neoplasms - therapy ; Male ; Middle Aged ; Neoadjuvant Therapy ; Proto-Oncogene Proteins c-met - biosynthesis ; Proto-Oncogene Proteins p21(ras) - genetics</subject><ispartof>Pathology, research and practice, 2017-08, Vol.213 (8), p.1002-1009</ispartof><rights>2017 Elsevier GmbH</rights><rights>Copyright © 2017 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-3eafa1b15e95d932a699d4e3e7fc4dc03e0cec0567b19c86cd461d63c9abd34a3</citedby><cites>FETCH-LOGICAL-c353t-3eafa1b15e95d932a699d4e3e7fc4dc03e0cec0567b19c86cd461d63c9abd34a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prp.2017.04.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28559118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorenzon, Laura</creatorcontrib><creatorcontrib>Ricca, Luana</creatorcontrib><creatorcontrib>Pilozzi, Emanuela</creatorcontrib><creatorcontrib>Lemoine, Antoinette</creatorcontrib><creatorcontrib>Riggio, Valentina</creatorcontrib><creatorcontrib>Giudice, Maria Teresa</creatorcontrib><creatorcontrib>Mallel, Giuseppe</creatorcontrib><creatorcontrib>Fochetti, Flavio</creatorcontrib><creatorcontrib>Balducci, Genoveffa</creatorcontrib><title>Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Recently TRG, necrosis grade and the rate of viable cancer cells of colorectal liver metastases were correlated with the response to chemotherapy treatments, whereas K-RAS mutations and c-MET over-expression were correlated with the prognosis.
58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly. We investigated the K-RAS mutational profile, the c-MET over-expression along with patients’ survivals curves.
Patients undergone neo-adjuvant treatment presented significant higher fibrosis rates and lower rates of viable cells. 36.7% of the patients had a K-RAS mutation and the 26.7% presented c-MET over-expression, but these features did not correlate with patients’ clinical/pathological data. Survival analysis documented that K-RAS WT patients presenting c-MET over-expression had worse outcomes.
Fibrosis and the rate of viable cells significantly correlate with the response to chemotherapy treatments. c-MET is a promising marker in K-RAS WT patients.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>C-MET</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Disease-Free Survival</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Fibrosis - pathology</subject><subject>Humans</subject><subject>K-RAS</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver metastasis</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Proto-Oncogene Proteins c-met - biosynthesis</subject><subject>Proto-Oncogene Proteins p21(ras) - genetics</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhoO46Kz6A7xIjh7s3qpJOtONJxl0lXVZ0PHiJWSSasnQXybdwv57M4x6FAoKqt56q-ph7BQhR0D1a5MPYcjngIscZA4o9tgMFZYZKIH7bAZCygyEKA_Zzxg3ALAAiQfscF4WRYVYztjzamr7wAO9BIrR9x1_CcZRvOB_soerR95OoxlT2TR8CH3tG-Kmc9xmf69X3Hfc9k0fyI6p3_g3Cryl0cQUFI_Zj9o0kU4-8hF7urleLW-z-3-_75ZX95kVhRgzQaY2uMaCqsJVYm5UVTlJgha1lc6CILBkoVCLNVa2VNZJhU4JW5m1E9KII3a-800Hvk4UR936aKlpTEf9FDVWIOdplYIkxZ3Uhj7GQLUegm9N-K8R9Bap3qTKoLdINUidkKaZsw_7ad2S-5r4ZJgElzsBpSffPAUdrafOkvNbMtr1_hv7d6CRh3Q</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Lorenzon, Laura</creator><creator>Ricca, Luana</creator><creator>Pilozzi, Emanuela</creator><creator>Lemoine, Antoinette</creator><creator>Riggio, Valentina</creator><creator>Giudice, Maria Teresa</creator><creator>Mallel, Giuseppe</creator><creator>Fochetti, Flavio</creator><creator>Balducci, Genoveffa</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases</title><author>Lorenzon, Laura ; 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58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly. We investigated the K-RAS mutational profile, the c-MET over-expression along with patients’ survivals curves.
Patients undergone neo-adjuvant treatment presented significant higher fibrosis rates and lower rates of viable cells. 36.7% of the patients had a K-RAS mutation and the 26.7% presented c-MET over-expression, but these features did not correlate with patients’ clinical/pathological data. Survival analysis documented that K-RAS WT patients presenting c-MET over-expression had worse outcomes.
Fibrosis and the rate of viable cells significantly correlate with the response to chemotherapy treatments. c-MET is a promising marker in K-RAS WT patients.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>28559118</pmid><doi>10.1016/j.prp.2017.04.013</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - secondary Adenocarcinoma - therapy Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis C-MET Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Disease-Free Survival DNA Mutational Analysis Female Fibrosis - pathology Humans K-RAS Kaplan-Meier Estimate Liver metastasis Liver Neoplasms - genetics Liver Neoplasms - secondary Liver Neoplasms - therapy Male Middle Aged Neoadjuvant Therapy Proto-Oncogene Proteins c-met - biosynthesis Proto-Oncogene Proteins p21(ras) - genetics |
| title | Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases |
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