Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection

CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. We evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis v...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2015-01, Vol.347 (6219), p.278-282
Hauptverfasser:	Penaloza-MacMaster, Pablo, Barber, Daniel L., Wherry, E. John, Provine, Nicholas M., Teigler, Jeffrey E., Parenteau, Lily, Blackmore, Stephen, Borducchi, Erica N., Larocca, Rafael A., Yates, Kathleen B., Shen, Hao, Haining, W. Nicholas, Sommerstein, Rami, Pinschewer, Daniel D., Ahmed, Rafi, Barouch, Dan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antibodies Antibodies, Viral - immunology Antigens, Viral - immunology Arenaviridae Infections - immunology Arenaviridae Infections - virology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cellular biology Cytokines Cytokines - blood Epitopes, T-Lymphocyte - immunology Immune system Immune System Diseases - etiology Immune System Diseases - immunology Immune System Diseases - pathology Immunologic Memory Inflammation - etiology Inflammation - immunology Inflammation - pathology Lentivirus Lymphocytes Lymphocytic choriomeningitis virus Lymphocytic choriomeningitis virus - immunology Lymphocytic choriomeningitis virus - physiology Memory Mice Mice, Inbred C57BL Mortality Multiple Organ Failure - etiology Pathology Retroviridae Storms Vaccination Vaccines Viral infections Viral Load Viral Vaccines - adverse effects Viral Vaccines - immunology Virus Replication Viruses
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