Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling

Infections and inflammation can lead to cachexia and wasting of skeletal muscle and fat tissue by as yet poorly understood mechanisms. We observed that gut colonization of mice by a strain of Escherichia coli prevents wasting triggered by infections or physical damage to the intestine. During intest...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2015-10, Vol.350 (6260), p.558-563
Hauptverfasser:	Schieber, Alexandria M. Palaferri, Lee, Yujung Michelle, Chang, Max W., Leblanc, Mathias, Collins, Brett, Downes, Michael, Evans, Ronald M., Ayres, Janelle S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - metabolism Biosynthetic Pathways Burkholderia Burkholderia Infections - complications Burkholderia thailandensis Calcium-Binding Proteins - metabolism Damage Disease management E coli Escherichia coli Escherichia coli - immunology Inflammasomes - immunology Inflammatory diseases Insulin-Like Growth Factor I - metabolism Intestines - microbiology Mice Mice, Inbred C57BL Microbiota Muscle, Skeletal - metabolism Muscles Pathogens Pathways Phosphatidylinositol 3-Kinase - metabolism Protective Proto-Oncogene Proteins c-akt - metabolism Salmonella Salmonella Infections - complications Salmonella typhimurium Signaling Tolerances Wasting Syndrome - etiology Wasting Syndrome - immunology Wasting Syndrome - microbiology
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