N-Heterocyclic carbene copper-catalyzed direct alkylation of terminal alkynes with non-activated alkyl triflates
(NHC)-Cu-catalyzed C(sp)-C(sp ) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C-O electrophiles. Mechanistic studies suggested that copper acetylide was the active species. Scale-up rea...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2017-04, Vol.53 (29), p.4124-4127 |
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| container_end_page | 4127 |
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| container_issue | 29 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 53 |
| creator | Jin, Liqun Hao, Wangfang Xu, Jianeng Sun, Nan Hu, Baoxiang Shen, Zhenlu Mo, Weimin Hu, Xinquan |
| description | (NHC)-Cu-catalyzed C(sp)-C(sp
) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C-O electrophiles. Mechanistic studies suggested that copper acetylide was the active species. Scale-up reactions further demonstrated the practicality and efficiency of the developed strategy. |
| doi_str_mv | 10.1039/c7cc00891k |
| format | Article |
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) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C-O electrophiles. Mechanistic studies suggested that copper acetylide was the active species. Scale-up reactions further demonstrated the practicality and efficiency of the developed strategy.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c7cc00891k</identifier><identifier>PMID: 28352858</identifier><language>eng</language><publisher>England</publisher><subject>Alkylation ; Alkynes ; Bonding ; Carbenes ; Copper ; Efficiency ; Strategy ; Terminals</subject><ispartof>Chemical communications (Cambridge, England), 2017-04, Vol.53 (29), p.4124-4127</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-64a916823bcfbea75c84fa43f24b9caa144affd00adf3ce551787bd832afe3b53</citedby><cites>FETCH-LOGICAL-c320t-64a916823bcfbea75c84fa43f24b9caa144affd00adf3ce551787bd832afe3b53</cites><orcidid>0000-0002-9518-7423 ; 0000-0002-3699-1198</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28352858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Liqun</creatorcontrib><creatorcontrib>Hao, Wangfang</creatorcontrib><creatorcontrib>Xu, Jianeng</creatorcontrib><creatorcontrib>Sun, Nan</creatorcontrib><creatorcontrib>Hu, Baoxiang</creatorcontrib><creatorcontrib>Shen, Zhenlu</creatorcontrib><creatorcontrib>Mo, Weimin</creatorcontrib><creatorcontrib>Hu, Xinquan</creatorcontrib><title>N-Heterocyclic carbene copper-catalyzed direct alkylation of terminal alkynes with non-activated alkyl triflates</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>(NHC)-Cu-catalyzed C(sp)-C(sp
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2017-04, Vol.53 (29), p.4124-4127 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1904210919 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alkylation Alkynes Bonding Carbenes Copper Efficiency Strategy Terminals |
| title | N-Heterocyclic carbene copper-catalyzed direct alkylation of terminal alkynes with non-activated alkyl triflates |
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